Low urinary estrogen glucuronides in women at risk for familial breast cancer

Jack Fishman, David K. Fukushima, John O'Connor, Henry T. Lynch

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Daily (12-hour) urine collections taken throughout the menstrual cycle were obtained from 30 young women who by genetic analysis were at risk for familial breast cancer, and from 30 control women carefully matched for age, height, and reproductive history. Steroids in the urine were extracted by glucuronidase hydrolysis, and the primary glucocorticoid, androgen, and estrogen hormones and their metabolites were measured by radioimmunoassay. Highly significant differences were observed only in the case of estrone and estradiol, with the high-risk subjects exhibiting lower values than the controls. This endocrine abnormality in young women at risk for breast cancer may be a potential discriminant for identifying women at risk for the disease in the population at large.

Original languageEnglish (US)
Pages (from-to)1089-1091
Number of pages3
JournalScience
Volume204
Issue number4397
StatePublished - 1979

Fingerprint

Glucuronides
Estrogens
Reproductive History
Urine Specimen Collection
Estrone
Glucuronidase
Menstrual Cycle
Glucocorticoids
Androgens
Radioimmunoassay
Estradiol
Hydrolysis
Steroids
Urine
Hormones
Breast Neoplasms
Familial Breast Cancer
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • General

Cite this

Fishman, J., Fukushima, D. K., O'Connor, J., & Lynch, H. T. (1979). Low urinary estrogen glucuronides in women at risk for familial breast cancer. Science, 204(4397), 1089-1091.

Low urinary estrogen glucuronides in women at risk for familial breast cancer. / Fishman, Jack; Fukushima, David K.; O'Connor, John; Lynch, Henry T.

In: Science, Vol. 204, No. 4397, 1979, p. 1089-1091.

Research output: Contribution to journalArticle

Fishman, J, Fukushima, DK, O'Connor, J & Lynch, HT 1979, 'Low urinary estrogen glucuronides in women at risk for familial breast cancer', Science, vol. 204, no. 4397, pp. 1089-1091.
Fishman J, Fukushima DK, O'Connor J, Lynch HT. Low urinary estrogen glucuronides in women at risk for familial breast cancer. Science. 1979;204(4397):1089-1091.
Fishman, Jack ; Fukushima, David K. ; O'Connor, John ; Lynch, Henry T. / Low urinary estrogen glucuronides in women at risk for familial breast cancer. In: Science. 1979 ; Vol. 204, No. 4397. pp. 1089-1091.
@article{a4e973e9bc13489d8987c4c99ecb83ae,
title = "Low urinary estrogen glucuronides in women at risk for familial breast cancer",
abstract = "Daily (12-hour) urine collections taken throughout the menstrual cycle were obtained from 30 young women who by genetic analysis were at risk for familial breast cancer, and from 30 control women carefully matched for age, height, and reproductive history. Steroids in the urine were extracted by glucuronidase hydrolysis, and the primary glucocorticoid, androgen, and estrogen hormones and their metabolites were measured by radioimmunoassay. Highly significant differences were observed only in the case of estrone and estradiol, with the high-risk subjects exhibiting lower values than the controls. This endocrine abnormality in young women at risk for breast cancer may be a potential discriminant for identifying women at risk for the disease in the population at large.",
author = "Jack Fishman and Fukushima, {David K.} and John O'Connor and Lynch, {Henry T.}",
year = "1979",
language = "English (US)",
volume = "204",
pages = "1089--1091",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4397",

}

TY - JOUR

T1 - Low urinary estrogen glucuronides in women at risk for familial breast cancer

AU - Fishman, Jack

AU - Fukushima, David K.

AU - O'Connor, John

AU - Lynch, Henry T.

PY - 1979

Y1 - 1979

N2 - Daily (12-hour) urine collections taken throughout the menstrual cycle were obtained from 30 young women who by genetic analysis were at risk for familial breast cancer, and from 30 control women carefully matched for age, height, and reproductive history. Steroids in the urine were extracted by glucuronidase hydrolysis, and the primary glucocorticoid, androgen, and estrogen hormones and their metabolites were measured by radioimmunoassay. Highly significant differences were observed only in the case of estrone and estradiol, with the high-risk subjects exhibiting lower values than the controls. This endocrine abnormality in young women at risk for breast cancer may be a potential discriminant for identifying women at risk for the disease in the population at large.

AB - Daily (12-hour) urine collections taken throughout the menstrual cycle were obtained from 30 young women who by genetic analysis were at risk for familial breast cancer, and from 30 control women carefully matched for age, height, and reproductive history. Steroids in the urine were extracted by glucuronidase hydrolysis, and the primary glucocorticoid, androgen, and estrogen hormones and their metabolites were measured by radioimmunoassay. Highly significant differences were observed only in the case of estrone and estradiol, with the high-risk subjects exhibiting lower values than the controls. This endocrine abnormality in young women at risk for breast cancer may be a potential discriminant for identifying women at risk for the disease in the population at large.

UR - http://www.scopus.com/inward/record.url?scp=0018580275&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018580275&partnerID=8YFLogxK

M3 - Article

VL - 204

SP - 1089

EP - 1091

JO - Science

JF - Science

SN - 0036-8075

IS - 4397

ER -