Lumbar spine bone mineral apparent density in children

Results from the bone mineral density in childhood study

Joseph M. Kindler, Joan M. Lappe, Vicente Gilsanz, Sharon Oberfield, John A. Shepherd, Andrea Kelly, Karen K. Winer, Heidi J. Kalkwarf, Babette S. Zemel

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Context: Dual-energy X-ray absorptiometry (DXA) is a cornerstone of pediatric bone health assessment, yet differences in height-for-age confound the interpretation of areal bone mineral density (aBMD) measures. To reduce the confounding of short stature on spine bone density, use of bone mineral apparent density (BMAD) and height-for-age Z-score (HAZ).adjusted aBMD (aBMDHAZ) are recommended. However, spine BMAD reference data are sparse, and the degree to which BMAD and aBMDHAZ account for height-related artifacts in bone density remains unclear. Objective: We developed age-, sex-, and population ancestry.specific spine BMAD reference ranges; compared height-adjustment methods in accounting for shorter stature; and assessed the stability of these measures over time. Design: Secondary analysis of data from a previous longitudinal study. Participants: Children and adolescents aged 5 to 19 years at baseline (n = 2014; 922 males; 22% black) from the Bone Mineral Density in Childhood Study. Main Outcome Measures: Lumbar spine BMAD and aBMDHAZ from DXA. Results: Spine BMAD increased nonlinearly with age and was greater in blacks and females (all P < 0.001). Age-specific spine BMAD z-score reference curves were constructed for black and non.black males and females. Overall, both BMAD and aBMD HAZ z scores reduced the confounding influence of shorter stature, but neitherwas consistently unbiased across all age ranges. BothBMAD and aBMD HAZ z scores tracked strongly over 6 years (r = 0.70 to 0.80; all P < 0.001). Conclusion: This study provided robust spine BMAD reference ranges and demonstrated that BMAD and aBMDHAZ partially reduced the confounding influence of shorter stature on bone density.

Original languageEnglish (US)
Pages (from-to)1283-1292
Number of pages10
JournalJournal of Clinical Endocrinology and Metabolism
Volume104
Issue number4
DOIs
StatePublished - Apr 1 2019

Fingerprint

Bone Density
Minerals
Bone
Spine
Photon Absorptiometry
Reference Values
X rays
Pediatrics
Artifacts
Longitudinal Studies

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Lumbar spine bone mineral apparent density in children : Results from the bone mineral density in childhood study. / Kindler, Joseph M.; Lappe, Joan M.; Gilsanz, Vicente; Oberfield, Sharon; Shepherd, John A.; Kelly, Andrea; Winer, Karen K.; Kalkwarf, Heidi J.; Zemel, Babette S.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 104, No. 4, 01.04.2019, p. 1283-1292.

Research output: Contribution to journalArticle

Kindler, JM, Lappe, JM, Gilsanz, V, Oberfield, S, Shepherd, JA, Kelly, A, Winer, KK, Kalkwarf, HJ & Zemel, BS 2019, 'Lumbar spine bone mineral apparent density in children: Results from the bone mineral density in childhood study', Journal of Clinical Endocrinology and Metabolism, vol. 104, no. 4, pp. 1283-1292. https://doi.org/10.1210/jc.2018-01693
Kindler, Joseph M. ; Lappe, Joan M. ; Gilsanz, Vicente ; Oberfield, Sharon ; Shepherd, John A. ; Kelly, Andrea ; Winer, Karen K. ; Kalkwarf, Heidi J. ; Zemel, Babette S. / Lumbar spine bone mineral apparent density in children : Results from the bone mineral density in childhood study. In: Journal of Clinical Endocrinology and Metabolism. 2019 ; Vol. 104, No. 4. pp. 1283-1292.
@article{96c2c4e379f549898a1a8e93819c114c,
title = "Lumbar spine bone mineral apparent density in children: Results from the bone mineral density in childhood study",
abstract = "Context: Dual-energy X-ray absorptiometry (DXA) is a cornerstone of pediatric bone health assessment, yet differences in height-for-age confound the interpretation of areal bone mineral density (aBMD) measures. To reduce the confounding of short stature on spine bone density, use of bone mineral apparent density (BMAD) and height-for-age Z-score (HAZ).adjusted aBMD (aBMDHAZ) are recommended. However, spine BMAD reference data are sparse, and the degree to which BMAD and aBMDHAZ account for height-related artifacts in bone density remains unclear. Objective: We developed age-, sex-, and population ancestry.specific spine BMAD reference ranges; compared height-adjustment methods in accounting for shorter stature; and assessed the stability of these measures over time. Design: Secondary analysis of data from a previous longitudinal study. Participants: Children and adolescents aged 5 to 19 years at baseline (n = 2014; 922 males; 22{\%} black) from the Bone Mineral Density in Childhood Study. Main Outcome Measures: Lumbar spine BMAD and aBMDHAZ from DXA. Results: Spine BMAD increased nonlinearly with age and was greater in blacks and females (all P < 0.001). Age-specific spine BMAD z-score reference curves were constructed for black and non.black males and females. Overall, both BMAD and aBMD HAZ z scores reduced the confounding influence of shorter stature, but neitherwas consistently unbiased across all age ranges. BothBMAD and aBMD HAZ z scores tracked strongly over 6 years (r = 0.70 to 0.80; all P < 0.001). Conclusion: This study provided robust spine BMAD reference ranges and demonstrated that BMAD and aBMDHAZ partially reduced the confounding influence of shorter stature on bone density.",
author = "Kindler, {Joseph M.} and Lappe, {Joan M.} and Vicente Gilsanz and Sharon Oberfield and Shepherd, {John A.} and Andrea Kelly and Winer, {Karen K.} and Kalkwarf, {Heidi J.} and Zemel, {Babette S.}",
year = "2019",
month = "4",
day = "1",
doi = "10.1210/jc.2018-01693",
language = "English (US)",
volume = "104",
pages = "1283--1292",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "4",

}

TY - JOUR

T1 - Lumbar spine bone mineral apparent density in children

T2 - Results from the bone mineral density in childhood study

AU - Kindler, Joseph M.

AU - Lappe, Joan M.

AU - Gilsanz, Vicente

AU - Oberfield, Sharon

AU - Shepherd, John A.

AU - Kelly, Andrea

AU - Winer, Karen K.

AU - Kalkwarf, Heidi J.

AU - Zemel, Babette S.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Context: Dual-energy X-ray absorptiometry (DXA) is a cornerstone of pediatric bone health assessment, yet differences in height-for-age confound the interpretation of areal bone mineral density (aBMD) measures. To reduce the confounding of short stature on spine bone density, use of bone mineral apparent density (BMAD) and height-for-age Z-score (HAZ).adjusted aBMD (aBMDHAZ) are recommended. However, spine BMAD reference data are sparse, and the degree to which BMAD and aBMDHAZ account for height-related artifacts in bone density remains unclear. Objective: We developed age-, sex-, and population ancestry.specific spine BMAD reference ranges; compared height-adjustment methods in accounting for shorter stature; and assessed the stability of these measures over time. Design: Secondary analysis of data from a previous longitudinal study. Participants: Children and adolescents aged 5 to 19 years at baseline (n = 2014; 922 males; 22% black) from the Bone Mineral Density in Childhood Study. Main Outcome Measures: Lumbar spine BMAD and aBMDHAZ from DXA. Results: Spine BMAD increased nonlinearly with age and was greater in blacks and females (all P < 0.001). Age-specific spine BMAD z-score reference curves were constructed for black and non.black males and females. Overall, both BMAD and aBMD HAZ z scores reduced the confounding influence of shorter stature, but neitherwas consistently unbiased across all age ranges. BothBMAD and aBMD HAZ z scores tracked strongly over 6 years (r = 0.70 to 0.80; all P < 0.001). Conclusion: This study provided robust spine BMAD reference ranges and demonstrated that BMAD and aBMDHAZ partially reduced the confounding influence of shorter stature on bone density.

AB - Context: Dual-energy X-ray absorptiometry (DXA) is a cornerstone of pediatric bone health assessment, yet differences in height-for-age confound the interpretation of areal bone mineral density (aBMD) measures. To reduce the confounding of short stature on spine bone density, use of bone mineral apparent density (BMAD) and height-for-age Z-score (HAZ).adjusted aBMD (aBMDHAZ) are recommended. However, spine BMAD reference data are sparse, and the degree to which BMAD and aBMDHAZ account for height-related artifacts in bone density remains unclear. Objective: We developed age-, sex-, and population ancestry.specific spine BMAD reference ranges; compared height-adjustment methods in accounting for shorter stature; and assessed the stability of these measures over time. Design: Secondary analysis of data from a previous longitudinal study. Participants: Children and adolescents aged 5 to 19 years at baseline (n = 2014; 922 males; 22% black) from the Bone Mineral Density in Childhood Study. Main Outcome Measures: Lumbar spine BMAD and aBMDHAZ from DXA. Results: Spine BMAD increased nonlinearly with age and was greater in blacks and females (all P < 0.001). Age-specific spine BMAD z-score reference curves were constructed for black and non.black males and females. Overall, both BMAD and aBMD HAZ z scores reduced the confounding influence of shorter stature, but neitherwas consistently unbiased across all age ranges. BothBMAD and aBMD HAZ z scores tracked strongly over 6 years (r = 0.70 to 0.80; all P < 0.001). Conclusion: This study provided robust spine BMAD reference ranges and demonstrated that BMAD and aBMDHAZ partially reduced the confounding influence of shorter stature on bone density.

UR - http://www.scopus.com/inward/record.url?scp=85062218058&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062218058&partnerID=8YFLogxK

U2 - 10.1210/jc.2018-01693

DO - 10.1210/jc.2018-01693

M3 - Article

VL - 104

SP - 1283

EP - 1292

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 4

ER -