Lymphoscintigraphy and sentinel node biopsy accurately stage melanoma in patients presenting after wide local excision

Heather L. Evans, David N. Krag, C. David Teates, James W. Patterson, Sybren Meijer, Seth P. Harlow, Kenneth K. Tanabe, Brian W. Loggie, Patrick W. Whitworth, Roberto E. Kusminsky, Ned Z. Carp, Michelle A. Gadd, Craig L. Slingluff

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: Patients have traditionally been considered candidates for sentinel node biopsy (SNBx) only at the time of wide local excision (WLE). We hypothesized that patients with prior WLE may also be staged accurately with SNBx. Methods: Seventy-six patients, including 18 patients from the University of Virginia and 58 from a multicenter study of SNBx led by investigators at the University of Vermont, who had previous WLE for clinically localized melanoma underwent lymphoscintigraphy with SNBx. Median follow-up time was 38 months. Results: Intraoperative identification of at least 1 sentinel node was accomplished in 75 patients (98.6%). The mean number of sentinel nodes removed per patient was 2.0. Eleven patients (15%) had positive sentinel nodes. Among the 64 patients with negative SNBx, 3 (4%) developed nodal recurrences in a sentinel node-negative basin simultaneous with systemic metastasis, and 1 (1%) developed an isolated first recurrence in a lymph node. Conclusions: This multicenter study more than doubles the published experience with SNBx after WLE and provides much-needed outcome data on recurrence after SNBx in these patients. These outcomes compare favorably with the reported literature for patients with SNBx at the time of WLE, suggesting that accurate staging of the regional lymph node bed is possible in patients after WLE.

Original languageEnglish
Pages (from-to)416-425
Number of pages10
JournalAnnals of Surgical Oncology
Volume10
Issue number4
DOIs
StatePublished - 2003

Fingerprint

Lymphoscintigraphy
Melanoma
Biopsy
Recurrence
Multicenter Studies
cyhalothrin
Lymph Nodes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Evans, H. L., Krag, D. N., Teates, C. D., Patterson, J. W., Meijer, S., Harlow, S. P., ... Slingluff, C. L. (2003). Lymphoscintigraphy and sentinel node biopsy accurately stage melanoma in patients presenting after wide local excision. Annals of Surgical Oncology, 10(4), 416-425. https://doi.org/10.1245/ASO.2003.05.009

Lymphoscintigraphy and sentinel node biopsy accurately stage melanoma in patients presenting after wide local excision. / Evans, Heather L.; Krag, David N.; Teates, C. David; Patterson, James W.; Meijer, Sybren; Harlow, Seth P.; Tanabe, Kenneth K.; Loggie, Brian W.; Whitworth, Patrick W.; Kusminsky, Roberto E.; Carp, Ned Z.; Gadd, Michelle A.; Slingluff, Craig L.

In: Annals of Surgical Oncology, Vol. 10, No. 4, 2003, p. 416-425.

Research output: Contribution to journalArticle

Evans, HL, Krag, DN, Teates, CD, Patterson, JW, Meijer, S, Harlow, SP, Tanabe, KK, Loggie, BW, Whitworth, PW, Kusminsky, RE, Carp, NZ, Gadd, MA & Slingluff, CL 2003, 'Lymphoscintigraphy and sentinel node biopsy accurately stage melanoma in patients presenting after wide local excision', Annals of Surgical Oncology, vol. 10, no. 4, pp. 416-425. https://doi.org/10.1245/ASO.2003.05.009
Evans, Heather L. ; Krag, David N. ; Teates, C. David ; Patterson, James W. ; Meijer, Sybren ; Harlow, Seth P. ; Tanabe, Kenneth K. ; Loggie, Brian W. ; Whitworth, Patrick W. ; Kusminsky, Roberto E. ; Carp, Ned Z. ; Gadd, Michelle A. ; Slingluff, Craig L. / Lymphoscintigraphy and sentinel node biopsy accurately stage melanoma in patients presenting after wide local excision. In: Annals of Surgical Oncology. 2003 ; Vol. 10, No. 4. pp. 416-425.
@article{0c5b127f69384288902a481da3cfcf0f,
title = "Lymphoscintigraphy and sentinel node biopsy accurately stage melanoma in patients presenting after wide local excision",
abstract = "Background: Patients have traditionally been considered candidates for sentinel node biopsy (SNBx) only at the time of wide local excision (WLE). We hypothesized that patients with prior WLE may also be staged accurately with SNBx. Methods: Seventy-six patients, including 18 patients from the University of Virginia and 58 from a multicenter study of SNBx led by investigators at the University of Vermont, who had previous WLE for clinically localized melanoma underwent lymphoscintigraphy with SNBx. Median follow-up time was 38 months. Results: Intraoperative identification of at least 1 sentinel node was accomplished in 75 patients (98.6{\%}). The mean number of sentinel nodes removed per patient was 2.0. Eleven patients (15{\%}) had positive sentinel nodes. Among the 64 patients with negative SNBx, 3 (4{\%}) developed nodal recurrences in a sentinel node-negative basin simultaneous with systemic metastasis, and 1 (1{\%}) developed an isolated first recurrence in a lymph node. Conclusions: This multicenter study more than doubles the published experience with SNBx after WLE and provides much-needed outcome data on recurrence after SNBx in these patients. These outcomes compare favorably with the reported literature for patients with SNBx at the time of WLE, suggesting that accurate staging of the regional lymph node bed is possible in patients after WLE.",
author = "Evans, {Heather L.} and Krag, {David N.} and Teates, {C. David} and Patterson, {James W.} and Sybren Meijer and Harlow, {Seth P.} and Tanabe, {Kenneth K.} and Loggie, {Brian W.} and Whitworth, {Patrick W.} and Kusminsky, {Roberto E.} and Carp, {Ned Z.} and Gadd, {Michelle A.} and Slingluff, {Craig L.}",
year = "2003",
doi = "10.1245/ASO.2003.05.009",
language = "English",
volume = "10",
pages = "416--425",
journal = "Annals of Surgical Oncology",
issn = "1068-9265",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Lymphoscintigraphy and sentinel node biopsy accurately stage melanoma in patients presenting after wide local excision

AU - Evans, Heather L.

AU - Krag, David N.

AU - Teates, C. David

AU - Patterson, James W.

AU - Meijer, Sybren

AU - Harlow, Seth P.

AU - Tanabe, Kenneth K.

AU - Loggie, Brian W.

AU - Whitworth, Patrick W.

AU - Kusminsky, Roberto E.

AU - Carp, Ned Z.

AU - Gadd, Michelle A.

AU - Slingluff, Craig L.

PY - 2003

Y1 - 2003

N2 - Background: Patients have traditionally been considered candidates for sentinel node biopsy (SNBx) only at the time of wide local excision (WLE). We hypothesized that patients with prior WLE may also be staged accurately with SNBx. Methods: Seventy-six patients, including 18 patients from the University of Virginia and 58 from a multicenter study of SNBx led by investigators at the University of Vermont, who had previous WLE for clinically localized melanoma underwent lymphoscintigraphy with SNBx. Median follow-up time was 38 months. Results: Intraoperative identification of at least 1 sentinel node was accomplished in 75 patients (98.6%). The mean number of sentinel nodes removed per patient was 2.0. Eleven patients (15%) had positive sentinel nodes. Among the 64 patients with negative SNBx, 3 (4%) developed nodal recurrences in a sentinel node-negative basin simultaneous with systemic metastasis, and 1 (1%) developed an isolated first recurrence in a lymph node. Conclusions: This multicenter study more than doubles the published experience with SNBx after WLE and provides much-needed outcome data on recurrence after SNBx in these patients. These outcomes compare favorably with the reported literature for patients with SNBx at the time of WLE, suggesting that accurate staging of the regional lymph node bed is possible in patients after WLE.

AB - Background: Patients have traditionally been considered candidates for sentinel node biopsy (SNBx) only at the time of wide local excision (WLE). We hypothesized that patients with prior WLE may also be staged accurately with SNBx. Methods: Seventy-six patients, including 18 patients from the University of Virginia and 58 from a multicenter study of SNBx led by investigators at the University of Vermont, who had previous WLE for clinically localized melanoma underwent lymphoscintigraphy with SNBx. Median follow-up time was 38 months. Results: Intraoperative identification of at least 1 sentinel node was accomplished in 75 patients (98.6%). The mean number of sentinel nodes removed per patient was 2.0. Eleven patients (15%) had positive sentinel nodes. Among the 64 patients with negative SNBx, 3 (4%) developed nodal recurrences in a sentinel node-negative basin simultaneous with systemic metastasis, and 1 (1%) developed an isolated first recurrence in a lymph node. Conclusions: This multicenter study more than doubles the published experience with SNBx after WLE and provides much-needed outcome data on recurrence after SNBx in these patients. These outcomes compare favorably with the reported literature for patients with SNBx at the time of WLE, suggesting that accurate staging of the regional lymph node bed is possible in patients after WLE.

UR - http://www.scopus.com/inward/record.url?scp=0041660568&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041660568&partnerID=8YFLogxK

U2 - 10.1245/ASO.2003.05.009

DO - 10.1245/ASO.2003.05.009

M3 - Article

VL - 10

SP - 416

EP - 425

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

IS - 4

ER -