Lynch syndrome in South America: past, present and future

Carlos A. Vaccaro, Carlos Sarroca, Benedito Rossi, Francisco Lopez-Kostner, Mev Dominguez, Natalia Causada Calo, Raul Cutait, Adriana Della Valle, Lina Nuñez, Florencia Neffa, Karin Alvarez, Maria Laura Gonzalez, Pablo Kalfayan, Henry T. Lynch, James Church

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

After decades of unawareness about Lynch syndrome, the medical community in South America is increasingly interested and informed. The visits and support of mentors like H. T. Lynch had been crucial to this awakening. Several countries have at least one registry with skilled personnel in genetic counseling and research. However, this only represents a very restricted resource for the region. According to the GETH, there are 27 hereditary cancer care centers in South America (21 in Brazil, 3 in Argentina, 1 in Uruguay, 1 in Chile and 1 in Peru). These registries differ in fundamental aspects of function, capabilities and funding, but are able to conduct high quality clinical, research and educational activities due to the dedication and personal effort of their members, and organizational support. More support from the governments as well as the participation of the community would boost the initiatives of people leading these groups. Meantime, the collaboration among the South American registries and the involvement of registries and leaders from developed countries will allow to maximize the efficiency in caring for affected patients and their families. The aim of this article is to describe how the knowledge of LS began to be spread in South America, how the first registries were organized and to summarize the current state of progress. In addition, we will provide an update of the clinical and molecular findings in the region.

Original languageEnglish (US)
Pages (from-to)437-445
Number of pages9
JournalFamilial cancer
Volume15
Issue number3
DOIs
StatePublished - Jul 1 2016

All Science Journal Classification (ASJC) codes

  • Genetics
  • Oncology
  • Genetics(clinical)
  • Cancer Research

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    Vaccaro, C. A., Sarroca, C., Rossi, B., Lopez-Kostner, F., Dominguez, M., Calo, N. C., Cutait, R., Valle, A. D., Nuñez, L., Neffa, F., Alvarez, K., Gonzalez, M. L., Kalfayan, P., Lynch, H. T., & Church, J. (2016). Lynch syndrome in South America: past, present and future. Familial cancer, 15(3), 437-445. https://doi.org/10.1007/s10689-016-9903-7