Müllerian intra-abdominal carcinomatosis in hereditary breast ovarian cancer syndrome: implications for risk-reducing surgery

Murray J. Casey, Agnes B. Colanta

Research output: Contribution to journalArticle

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Abstract

More than 40 years ago Lynch et al. described several multigenerational breast cancer family pedigrees which demonstrated autosomal dominant inheritance of a trait(s) that increased risks for both breast and ovarian cancers. Mutation carriers in at least 90 % of these hereditary breast ovarian cancer (HBOC) syndrome families have been linked to cancer-associated mutations in the genes BRCA1 and BRCA2. This review focuses on the contributions of Lynch, colleagues and collaborators and pertinent literature, toward defining the HBOC syndrome, the cancer risks that the inherited adverse mutations convey, the gynecologic tissues and organs from which the malignancy may arise to disseminate throughout the pelvic and abdominal organs and peritoneum and how this information can be used to reduce the risk and morbidities of intra-abdominal carcinomatosis in effected individuals.

Original languageEnglish
Pages (from-to)371-384
Number of pages14
JournalFamilial Cancer
Volume15
Issue number3
DOIs
StatePublished - Jul 1 2016

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Hereditary Breast and Ovarian Cancer Syndrome
Carcinoma
Mutation
BRCA2 Gene
Breast Neoplasms
BRCA1 Gene
Neoplasms
Peritoneum
Pedigree
Ovarian Neoplasms
Morbidity

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Genetics
  • Oncology
  • Genetics(clinical)

Cite this

Müllerian intra-abdominal carcinomatosis in hereditary breast ovarian cancer syndrome : implications for risk-reducing surgery. / Casey, Murray J.; Colanta, Agnes B.

In: Familial Cancer, Vol. 15, No. 3, 01.07.2016, p. 371-384.

Research output: Contribution to journalArticle

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