Abstract
The DNA mismatch repair (MMR) system provides critical genetic housekeeping, and its failure is associated with tumorigenesis. Through distinct domains on the DNA MMR proteins, the system recognizes and repairs errors occurring during DNA synthesis, but signals apoptosis when the DNA damage cannot be repaired. Certain missense mutations in the MMR genes can selectively alter just one of these functions. This affects the clinical features of tumors associated with defective DNA MMR activity. New work reported by Xie et al. in this issue of the journal (beginning on page 1409) adds to the understanding of DNA MMR.
| Original language | English |
|---|---|
| Pages (from-to) | 1371-1374 |
| Number of pages | 4 |
| Journal | Cancer Prevention Research |
| Volume | 3 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2010 |
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All Science Journal Classification (ASJC) codes
- Cancer Research
- Oncology
Cite this
Making sense of missense in Lynch syndrome : The clinical perspective. / Lynch, Henry T.; Jascur, Thomas; Lanspa, Stephen J.; Boland, C. Richard.
In: Cancer Prevention Research, Vol. 3, No. 11, 11.2010, p. 1371-1374.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Making sense of missense in Lynch syndrome
T2 - The clinical perspective
AU - Lynch, Henry T.
AU - Jascur, Thomas
AU - Lanspa, Stephen J.
AU - Boland, C. Richard
PY - 2010/11
Y1 - 2010/11
N2 - The DNA mismatch repair (MMR) system provides critical genetic housekeeping, and its failure is associated with tumorigenesis. Through distinct domains on the DNA MMR proteins, the system recognizes and repairs errors occurring during DNA synthesis, but signals apoptosis when the DNA damage cannot be repaired. Certain missense mutations in the MMR genes can selectively alter just one of these functions. This affects the clinical features of tumors associated with defective DNA MMR activity. New work reported by Xie et al. in this issue of the journal (beginning on page 1409) adds to the understanding of DNA MMR.
AB - The DNA mismatch repair (MMR) system provides critical genetic housekeeping, and its failure is associated with tumorigenesis. Through distinct domains on the DNA MMR proteins, the system recognizes and repairs errors occurring during DNA synthesis, but signals apoptosis when the DNA damage cannot be repaired. Certain missense mutations in the MMR genes can selectively alter just one of these functions. This affects the clinical features of tumors associated with defective DNA MMR activity. New work reported by Xie et al. in this issue of the journal (beginning on page 1409) adds to the understanding of DNA MMR.
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UR - http://www.scopus.com/inward/citedby.url?scp=78649251037&partnerID=8YFLogxK
U2 - 10.1158/1940-6207.CAPR-10-0204
DO - 10.1158/1940-6207.CAPR-10-0204
M3 - Review article
VL - 3
SP - 1371
EP - 1374
JO - Cancer Prevention Research
JF - Cancer Prevention Research
SN - 1940-6207
IS - 11
ER -