Making sense of missense in Lynch syndrome: The clinical perspective

Henry T. Lynch, Thomas Jascur, Stephen Lanspa, C. Richard Boland

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


The DNA mismatch repair (MMR) system provides critical genetic housekeeping, and its failure is associated with tumorigenesis. Through distinct domains on the DNA MMR proteins, the system recognizes and repairs errors occurring during DNA synthesis, but signals apoptosis when the DNA damage cannot be repaired. Certain missense mutations in the MMR genes can selectively alter just one of these functions. This affects the clinical features of tumors associated with defective DNA MMR activity. New work reported by Xie et al. in this issue of the journal (beginning on page 1409) adds to the understanding of DNA MMR.

Original languageEnglish (US)
Pages (from-to)1371-1374
Number of pages4
JournalCancer Prevention Research
Issue number11
StatePublished - Nov 2010

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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