Male breast cancer in the hereditary nonpolyposis colorectal cancer syndrome

Jeff Boyd, Esther Rhei, Mark G. Federici, Patrick I. Borgen, Patrice Watson, Barbara Franklin, Beth Karr, Jane Lynch, Stephen J. Lemon, Henry T. Lynch

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


A male member of a large HNPCC kindred, affected by primary malignancies of the breast and colon, was identified. This individual was found to harbor a germline mutation of the MLH1 mismatch repair gene previously shown to segregate with disease in this kindred. The breast tumor exhibited somatic reduction to homozygosity for the MLH1 mutation, and microsatellite instability was evident in the breast tumor. We conclude that hereditary male breast cancer can occur as an integral tumor in the HNPCC syndrome.

Original languageEnglish (US)
Pages (from-to)87-91
Number of pages5
JournalBreast Cancer Research and Treatment
Issue number1
StatePublished - 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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