Malignant Peritoneal Mesothelioma

Characterization of the Inflammatory Response in the Tumor Microenvironment

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Abstract

Background: Malignant peritoneal mesothelioma (MPM) is a rare cancer arising from mesothelial cells lining the peritoneal surface. Little is known about the tumor microenvironment in regulating MPM oncogenesis. The current study defined the chemokine/cytokine expression profile and inflammatory responses within the MPM microenvironment. Methods: Levels of 10 cytokines (Fractalkine, IFNγ, IL-6, IL-8, IP-10, MCP-1, MIP-1α, MIP-1β, TNFα, VEGF) in matched ascites and sera from 15 MPM patients were measured using Milliplex immunoassays. Sera from six normal control sera were included. Statistical analyses included the Wilcoxon signed-rank test, the Mann–Whitney U test, bivariate analysis, and the R2 coefficient of correlation. Results: The median levels of IL-6 (3190 vs 3.18 ng/ml; p <0.001), IL-8 (118 vs 4.93 ng/ml; p 

Original languageEnglish
Pages (from-to)1496-1500
Number of pages5
JournalAnnals of Surgical Oncology
Volume23
Issue number5
DOIs
StatePublished - May 1 2016

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Tumor Microenvironment
Interleukin-8
Interleukin-6
Serum
Chemokine CX3CL1
Cytokines
Nonparametric Statistics
Chemokines
Immunoassay
Ascites
Vascular Endothelial Growth Factor A
Carcinogenesis
Malignant Mesothelioma
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

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title = "Malignant Peritoneal Mesothelioma: Characterization of the Inflammatory Response in the Tumor Microenvironment",
abstract = "Background: Malignant peritoneal mesothelioma (MPM) is a rare cancer arising from mesothelial cells lining the peritoneal surface. Little is known about the tumor microenvironment in regulating MPM oncogenesis. The current study defined the chemokine/cytokine expression profile and inflammatory responses within the MPM microenvironment. Methods: Levels of 10 cytokines (Fractalkine, IFNγ, IL-6, IL-8, IP-10, MCP-1, MIP-1α, MIP-1β, TNFα, VEGF) in matched ascites and sera from 15 MPM patients were measured using Milliplex immunoassays. Sera from six normal control sera were included. Statistical analyses included the Wilcoxon signed-rank test, the Mann–Whitney U test, bivariate analysis, and the R2 coefficient of correlation. Results: The median levels of IL-6 (3190 vs 3.18 ng/ml; p <0.001), IL-8 (118 vs 4.93 ng/ml; p ",
author = "Sean Judge and Peter Thomas and Venkatesh Govindarajan and Sharma, {Poonam K} and Loggie, {Brian W.}",
year = "2016",
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pages = "1496--1500",
journal = "Annals of Surgical Oncology",
issn = "1068-9265",
publisher = "Springer New York",
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TY - JOUR

T1 - Malignant Peritoneal Mesothelioma

T2 - Characterization of the Inflammatory Response in the Tumor Microenvironment

AU - Judge, Sean

AU - Thomas, Peter

AU - Govindarajan, Venkatesh

AU - Sharma, Poonam K

AU - Loggie, Brian W.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Background: Malignant peritoneal mesothelioma (MPM) is a rare cancer arising from mesothelial cells lining the peritoneal surface. Little is known about the tumor microenvironment in regulating MPM oncogenesis. The current study defined the chemokine/cytokine expression profile and inflammatory responses within the MPM microenvironment. Methods: Levels of 10 cytokines (Fractalkine, IFNγ, IL-6, IL-8, IP-10, MCP-1, MIP-1α, MIP-1β, TNFα, VEGF) in matched ascites and sera from 15 MPM patients were measured using Milliplex immunoassays. Sera from six normal control sera were included. Statistical analyses included the Wilcoxon signed-rank test, the Mann–Whitney U test, bivariate analysis, and the R2 coefficient of correlation. Results: The median levels of IL-6 (3190 vs 3.18 ng/ml; p <0.001), IL-8 (118 vs 4.93 ng/ml; p 

AB - Background: Malignant peritoneal mesothelioma (MPM) is a rare cancer arising from mesothelial cells lining the peritoneal surface. Little is known about the tumor microenvironment in regulating MPM oncogenesis. The current study defined the chemokine/cytokine expression profile and inflammatory responses within the MPM microenvironment. Methods: Levels of 10 cytokines (Fractalkine, IFNγ, IL-6, IL-8, IP-10, MCP-1, MIP-1α, MIP-1β, TNFα, VEGF) in matched ascites and sera from 15 MPM patients were measured using Milliplex immunoassays. Sera from six normal control sera were included. Statistical analyses included the Wilcoxon signed-rank test, the Mann–Whitney U test, bivariate analysis, and the R2 coefficient of correlation. Results: The median levels of IL-6 (3190 vs 3.18 ng/ml; p <0.001), IL-8 (118 vs 4.93 ng/ml; p 

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U2 - 10.1245/s10434-015-4965-6

DO - 10.1245/s10434-015-4965-6

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EP - 1500

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

IS - 5

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