TY - JOUR
T1 - Malignant Peritoneal Mesothelioma
T2 - Characterization of the Inflammatory Response in the Tumor Microenvironment
AU - Judge, Sean
AU - Thomas, Peter
AU - Govindarajan, Venkatesh
AU - Sharma, Poonam
AU - Loggie, Brian
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Background: Malignant peritoneal mesothelioma (MPM) is a rare cancer arising from mesothelial cells lining the peritoneal surface. Little is known about the tumor microenvironment in regulating MPM oncogenesis. The current study defined the chemokine/cytokine expression profile and inflammatory responses within the MPM microenvironment. Methods: Levels of 10 cytokines (Fractalkine, IFNγ, IL-6, IL-8, IP-10, MCP-1, MIP-1α, MIP-1β, TNFα, VEGF) in matched ascites and sera from 15 MPM patients were measured using Milliplex immunoassays. Sera from six normal control sera were included. Statistical analyses included the Wilcoxon signed-rank test, the Mann–Whitney U test, bivariate analysis, and the R2 coefficient of correlation. Results: The median levels of IL-6 (3190 vs 3.18 ng/ml; p <0.001), IL-8 (118 vs 4.93 ng/ml; p
AB - Background: Malignant peritoneal mesothelioma (MPM) is a rare cancer arising from mesothelial cells lining the peritoneal surface. Little is known about the tumor microenvironment in regulating MPM oncogenesis. The current study defined the chemokine/cytokine expression profile and inflammatory responses within the MPM microenvironment. Methods: Levels of 10 cytokines (Fractalkine, IFNγ, IL-6, IL-8, IP-10, MCP-1, MIP-1α, MIP-1β, TNFα, VEGF) in matched ascites and sera from 15 MPM patients were measured using Milliplex immunoassays. Sera from six normal control sera were included. Statistical analyses included the Wilcoxon signed-rank test, the Mann–Whitney U test, bivariate analysis, and the R2 coefficient of correlation. Results: The median levels of IL-6 (3190 vs 3.18 ng/ml; p <0.001), IL-8 (118 vs 4.93 ng/ml; p
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U2 - 10.1245/s10434-015-4965-6
DO - 10.1245/s10434-015-4965-6
M3 - Article
C2 - 26545374
AN - SCOPUS:84946763423
VL - 23
SP - 1496
EP - 1500
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
SN - 1068-9265
IS - 5
ER -