Abstract
Background: Malignant peritoneal mesothelioma (MPM) is a rare cancer arising from mesothelial cells lining the peritoneal surface. Little is known about the tumor microenvironment in regulating MPM oncogenesis. The current study defined the chemokine/cytokine expression profile and inflammatory responses within the MPM microenvironment. Methods: Levels of 10 cytokines (Fractalkine, IFNγ, IL-6, IL-8, IP-10, MCP-1, MIP-1α, MIP-1β, TNFα, VEGF) in matched ascites and sera from 15 MPM patients were measured using Milliplex immunoassays. Sera from six normal control sera were included. Statistical analyses included the Wilcoxon signed-rank test, the Mann–Whitney U test, bivariate analysis, and the R2 coefficient of correlation. Results: The median levels of IL-6 (3190 vs 3.18 ng/ml; p <0.001), IL-8 (118 vs 4.93 ng/ml; p
| Original language | English |
|---|---|
| Pages (from-to) | 1496-1500 |
| Number of pages | 5 |
| Journal | Annals of Surgical Oncology |
| Volume | 23 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2016 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Oncology
Cite this
Malignant Peritoneal Mesothelioma : Characterization of the Inflammatory Response in the Tumor Microenvironment. / Judge, Sean; Thomas, Peter; Govindarajan, Venkatesh; Sharma, Poonam K; Loggie, Brian W.
In: Annals of Surgical Oncology, Vol. 23, No. 5, 01.05.2016, p. 1496-1500.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Malignant Peritoneal Mesothelioma
T2 - Characterization of the Inflammatory Response in the Tumor Microenvironment
AU - Judge, Sean
AU - Thomas, Peter
AU - Govindarajan, Venkatesh
AU - Sharma, Poonam K
AU - Loggie, Brian W.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Background: Malignant peritoneal mesothelioma (MPM) is a rare cancer arising from mesothelial cells lining the peritoneal surface. Little is known about the tumor microenvironment in regulating MPM oncogenesis. The current study defined the chemokine/cytokine expression profile and inflammatory responses within the MPM microenvironment. Methods: Levels of 10 cytokines (Fractalkine, IFNγ, IL-6, IL-8, IP-10, MCP-1, MIP-1α, MIP-1β, TNFα, VEGF) in matched ascites and sera from 15 MPM patients were measured using Milliplex immunoassays. Sera from six normal control sera were included. Statistical analyses included the Wilcoxon signed-rank test, the Mann–Whitney U test, bivariate analysis, and the R2 coefficient of correlation. Results: The median levels of IL-6 (3190 vs 3.18 ng/ml; p <0.001), IL-8 (118 vs 4.93 ng/ml; p
AB - Background: Malignant peritoneal mesothelioma (MPM) is a rare cancer arising from mesothelial cells lining the peritoneal surface. Little is known about the tumor microenvironment in regulating MPM oncogenesis. The current study defined the chemokine/cytokine expression profile and inflammatory responses within the MPM microenvironment. Methods: Levels of 10 cytokines (Fractalkine, IFNγ, IL-6, IL-8, IP-10, MCP-1, MIP-1α, MIP-1β, TNFα, VEGF) in matched ascites and sera from 15 MPM patients were measured using Milliplex immunoassays. Sera from six normal control sera were included. Statistical analyses included the Wilcoxon signed-rank test, the Mann–Whitney U test, bivariate analysis, and the R2 coefficient of correlation. Results: The median levels of IL-6 (3190 vs 3.18 ng/ml; p <0.001), IL-8 (118 vs 4.93 ng/ml; p
UR - http://www.scopus.com/inward/record.url?scp=84946763423&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84946763423&partnerID=8YFLogxK
U2 - 10.1245/s10434-015-4965-6
DO - 10.1245/s10434-015-4965-6
M3 - Article
VL - 23
SP - 1496
EP - 1500
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
SN - 1068-9265
IS - 5
ER -