Malignant Peritoneal Mesothelioma: Characterization of the Inflammatory Response in the Tumor Microenvironment

Sean Judge; Peter Thomas; Venkatesh Govindarajan; Poonam Sharma; Brian Loggie

doi:10.1245/s10434-015-4965-6

Malignant Peritoneal Mesothelioma: Characterization of the Inflammatory Response in the Tumor Microenvironment

Sean Judge, Peter Thomas, Venkatesh Govindarajan, Poonam Sharma, Brian Loggie

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Background: Malignant peritoneal mesothelioma (MPM) is a rare cancer arising from mesothelial cells lining the peritoneal surface. Little is known about the tumor microenvironment in regulating MPM oncogenesis. The current study defined the chemokine/cytokine expression profile and inflammatory responses within the MPM microenvironment. Methods: Levels of 10 cytokines (Fractalkine, IFNγ, IL-6, IL-8, IP-10, MCP-1, MIP-1α, MIP-1β, TNFα, VEGF) in matched ascites and sera from 15 MPM patients were measured using Milliplex immunoassays. Sera from six normal control sera were included. Statistical analyses included the Wilcoxon signed-rank test, the Mann–Whitney U test, bivariate analysis, and the R² coefficient of correlation. Results: The median levels of IL-6 (3190 vs 3.18 ng/ml; p <0.001), IL-8 (118 vs 4.93 ng/ml; p

Original language	English (US)
Pages (from-to)	1496-1500
Number of pages	5
Journal	Annals of Surgical Oncology
Volume	23
Issue number	5
DOIs	https://doi.org/10.1245/s10434-015-4965-6
State	Published - May 1 2016

All Science Journal Classification (ASJC) codes

Surgery
Oncology

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title = "Malignant Peritoneal Mesothelioma: Characterization of the Inflammatory Response in the Tumor Microenvironment",

abstract = "Background: Malignant peritoneal mesothelioma (MPM) is a rare cancer arising from mesothelial cells lining the peritoneal surface. Little is known about the tumor microenvironment in regulating MPM oncogenesis. The current study defined the chemokine/cytokine expression profile and inflammatory responses within the MPM microenvironment. Methods: Levels of 10 cytokines (Fractalkine, IFNγ, IL-6, IL-8, IP-10, MCP-1, MIP-1α, MIP-1β, TNFα, VEGF) in matched ascites and sera from 15 MPM patients were measured using Milliplex immunoassays. Sera from six normal control sera were included. Statistical analyses included the Wilcoxon signed-rank test, the Mann–Whitney U test, bivariate analysis, and the R2 coefficient of correlation. Results: The median levels of IL-6 (3190 vs 3.18 ng/ml; p <0.001), IL-8 (118 vs 4.93 ng/ml; p ",

author = "Sean Judge and Peter Thomas and Venkatesh Govindarajan and Poonam Sharma and Brian Loggie",

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language = "English (US)",

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issn = "1068-9265",

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TY - JOUR

T1 - Malignant Peritoneal Mesothelioma

T2 - Characterization of the Inflammatory Response in the Tumor Microenvironment

AU - Judge, Sean

AU - Thomas, Peter

AU - Govindarajan, Venkatesh

AU - Sharma, Poonam

AU - Loggie, Brian

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Background: Malignant peritoneal mesothelioma (MPM) is a rare cancer arising from mesothelial cells lining the peritoneal surface. Little is known about the tumor microenvironment in regulating MPM oncogenesis. The current study defined the chemokine/cytokine expression profile and inflammatory responses within the MPM microenvironment. Methods: Levels of 10 cytokines (Fractalkine, IFNγ, IL-6, IL-8, IP-10, MCP-1, MIP-1α, MIP-1β, TNFα, VEGF) in matched ascites and sera from 15 MPM patients were measured using Milliplex immunoassays. Sera from six normal control sera were included. Statistical analyses included the Wilcoxon signed-rank test, the Mann–Whitney U test, bivariate analysis, and the R2 coefficient of correlation. Results: The median levels of IL-6 (3190 vs 3.18 ng/ml; p <0.001), IL-8 (118 vs 4.93 ng/ml; p

AB - Background: Malignant peritoneal mesothelioma (MPM) is a rare cancer arising from mesothelial cells lining the peritoneal surface. Little is known about the tumor microenvironment in regulating MPM oncogenesis. The current study defined the chemokine/cytokine expression profile and inflammatory responses within the MPM microenvironment. Methods: Levels of 10 cytokines (Fractalkine, IFNγ, IL-6, IL-8, IP-10, MCP-1, MIP-1α, MIP-1β, TNFα, VEGF) in matched ascites and sera from 15 MPM patients were measured using Milliplex immunoassays. Sera from six normal control sera were included. Statistical analyses included the Wilcoxon signed-rank test, the Mann–Whitney U test, bivariate analysis, and the R2 coefficient of correlation. Results: The median levels of IL-6 (3190 vs 3.18 ng/ml; p <0.001), IL-8 (118 vs 4.93 ng/ml; p

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