Mammography screening and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers: A prospective study

Vasily Giannakeas, Jan Lubinski, Jacek Gronwald, Pal Moller, Susan Armel, Henry T. Lynch, William D. Foulkes, Charmaine Kim-Sing, Christian Singer, Susan L. Neuhausen, Eitan Friedman, Nadine Tung, Leigha Senter, Ping Sun, Steven A. Narod

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15 Scopus citations

Abstract

Women with a genetic predisposition to breast cancer may be at increased risk of cancer after exposure to ionizing radiation. It is unclear whether mammography screening increases the risk of breast cancer among BRCA1 and BRCA2 carriers. We identified 2,346 women with a BRCA1 (n = 1844) or BRCA2 (n = 502) mutation and no breast cancer, and we reviewed their history of mammography exposure. These women were followed for an average of 5.3 years and were observed for new breast cancer diagnoses. At study entry, 1808 women (77.1 %) reported ever having had a mammogram; of these, 204 women (11.2 %) reported having had a mammogram before age 30. We estimated the hazard ratios for the development of invasive breast cancer, conditional on the number of prior mammograms and on the age at first mammogram. Hazard ratios were estimated and stratified by gene (BRCA1 or BRCA2), relative to women with no exposure. We observed no significant association between prior mammography exposure and breast cancer risk for BRCA1 carriers (HR 0.79; 95 % CI 0.53-1.19; P = 0.26) or for BRCA2 carriers (HR 0.90; 95 % CI 0.35-2.34; P = 0.83). An early age at first mammogram (

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalBreast Cancer Research and Treatment
Volume147
Issue number1
DOIs
StatePublished - 2014

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research
  • Medicine(all)

Cite this

Giannakeas, V., Lubinski, J., Gronwald, J., Moller, P., Armel, S., Lynch, H. T., Foulkes, W. D., Kim-Sing, C., Singer, C., Neuhausen, S. L., Friedman, E., Tung, N., Senter, L., Sun, P., & Narod, S. A. (2014). Mammography screening and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers: A prospective study. Breast Cancer Research and Treatment, 147(1), 113-118. https://doi.org/10.1007/s10549-014-3063-y