Abstract
A1 adenosine receptors in rat prepiriform cortex (PPC) play an important role in the inhibition of bicuculline methiodide (BMI)-induced convulsions. In the present study, we evaluated the manipulation of endogenous adenosine in this brain area as a strategy to effect seizure suppression. All compounds evaluated were unilaterally microinjected into the PPC. Focal administration of 5' NH25'dADO and dilazep were found to be highly efficacious as anticonvulsants with respective ED50 values of 2.6 ± 0.8, and 5.6 ± 1.6 nmol. In contrast, 2'DCF was both less potent and less efficacious. These results suggest that accumulation of endogenous adenosine may contribute to seizure suppression, and that adenosine kinase and adenosine transport may play a pivotal role in the regulation of extracellular levels of adenosine in the CNS.
| Original language | English |
|---|---|
| Pages (from-to) | 410-415 |
| Number of pages | 6 |
| Journal | Drug Development Research |
| Volume | 28 |
| Issue number | 3 |
| State | Published - 1993 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Organic Chemistry
- Drug Discovery
- Pharmacology
Cite this
Manipulation of endogenous adenosine affects seizure susceptibility. / Murray, Thomas F.; Zhang, G.; Franklin, P. H.
In: Drug Development Research, Vol. 28, No. 3, 1993, p. 410-415.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Manipulation of endogenous adenosine affects seizure susceptibility
AU - Murray, Thomas F.
AU - Zhang, G.
AU - Franklin, P. H.
PY - 1993
Y1 - 1993
N2 - A1 adenosine receptors in rat prepiriform cortex (PPC) play an important role in the inhibition of bicuculline methiodide (BMI)-induced convulsions. In the present study, we evaluated the manipulation of endogenous adenosine in this brain area as a strategy to effect seizure suppression. All compounds evaluated were unilaterally microinjected into the PPC. Focal administration of 5' NH25'dADO and dilazep were found to be highly efficacious as anticonvulsants with respective ED50 values of 2.6 ± 0.8, and 5.6 ± 1.6 nmol. In contrast, 2'DCF was both less potent and less efficacious. These results suggest that accumulation of endogenous adenosine may contribute to seizure suppression, and that adenosine kinase and adenosine transport may play a pivotal role in the regulation of extracellular levels of adenosine in the CNS.
AB - A1 adenosine receptors in rat prepiriform cortex (PPC) play an important role in the inhibition of bicuculline methiodide (BMI)-induced convulsions. In the present study, we evaluated the manipulation of endogenous adenosine in this brain area as a strategy to effect seizure suppression. All compounds evaluated were unilaterally microinjected into the PPC. Focal administration of 5' NH25'dADO and dilazep were found to be highly efficacious as anticonvulsants with respective ED50 values of 2.6 ± 0.8, and 5.6 ± 1.6 nmol. In contrast, 2'DCF was both less potent and less efficacious. These results suggest that accumulation of endogenous adenosine may contribute to seizure suppression, and that adenosine kinase and adenosine transport may play a pivotal role in the regulation of extracellular levels of adenosine in the CNS.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027516921&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0027516921
VL - 28
SP - 410
EP - 415
JO - Drug Development Research
JF - Drug Development Research
SN - 0272-4391
IS - 3
ER -