Marijuana for the treatment of seizure disorders

Cannabis, the substance more commonly known as marijuana, has gained interest in recent years for its potential use as an antiepileptic agent. The two main components of marijuana are delta-9-tetrahydrocannabinol, which has had mixed effects in epilepsy, and cannabidiol, which has shown more consistent anticonvulsant effects. Data supporting the use of marijuana for this purpose are limited, as the majority of clinical trials were conducted before 1990. There are case reports showing promising results; however, the data are inconsistent and cannot be generalized. The legal issues surrounding marijuana in the United States also may limit the use of this substance as an antiepileptic.