Measurement of exhaled nitric oxide by three different techniques

Richard A. Robbins, Anthony A. Floreani, Susanna G. Von Essen, Joseph H. Sisson, Gary E. Hill, Israel Rubinstein, Robert G. Townley

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

The purpose of the study was to compare exhaled nitric oxide (NO) determined by three techniques. Ninety-one subjects performed a slow vital capacity maneuver: (1) through the mouth directly into a NO chemiluminescence analyzer (peak oral NO), (2) through the mouth into a collection bag (mean oral NO), and (3) through the nose into a collection bag (mean nasal NO). Peak oral NO was higher in patients with asthma (n = 18, 174.2 ± 27.0 ppb), but lower in smokers (n = 36, 39.6 ± 4.8 ppb) compared with nonsmoking control subjects (n = 23, 105.5 ± 8.4 ppb, p <0.05 both comparisons). Mean oral NO levels were significantly lower than peak oral NO levels (p <0.05), but still higher in patients with asthma in comparison with nonsmoking healthy control subjects and asymptomatic smokers (27.2 ± 3.5 versus 14.5 ± 1.1 and 7.3 ± 0.7 ppb, respectively, p <0.05). In contrast, there was no significant difference in mean nasal NO levels between the three groups. Peak oral NO and mean oral NO levels correlated (r = 0.772, p <0.0001). Determination of exhaled oral NO levels is qualitatively independent of the technique used, but nasal exhalation may affect NO determination in conditions associated with airway inflammation.

Original languageEnglish
Pages (from-to)1631-1635
Number of pages5
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume153
Issue number5
StatePublished - 1996
Externally publishedYes

Fingerprint

Nitric Oxide
Nose
Mouth
Asthma
Exhalation
Vital Capacity
Luminescence
Healthy Volunteers
Inflammation

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Robbins, R. A., Floreani, A. A., Von Essen, S. G., Sisson, J. H., Hill, G. E., Rubinstein, I., & Townley, R. G. (1996). Measurement of exhaled nitric oxide by three different techniques. American Journal of Respiratory and Critical Care Medicine, 153(5), 1631-1635.

Measurement of exhaled nitric oxide by three different techniques. / Robbins, Richard A.; Floreani, Anthony A.; Von Essen, Susanna G.; Sisson, Joseph H.; Hill, Gary E.; Rubinstein, Israel; Townley, Robert G.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 153, No. 5, 1996, p. 1631-1635.

Research output: Contribution to journalArticle

Robbins, RA, Floreani, AA, Von Essen, SG, Sisson, JH, Hill, GE, Rubinstein, I & Townley, RG 1996, 'Measurement of exhaled nitric oxide by three different techniques', American Journal of Respiratory and Critical Care Medicine, vol. 153, no. 5, pp. 1631-1635.
Robbins RA, Floreani AA, Von Essen SG, Sisson JH, Hill GE, Rubinstein I et al. Measurement of exhaled nitric oxide by three different techniques. American Journal of Respiratory and Critical Care Medicine. 1996;153(5):1631-1635.
Robbins, Richard A. ; Floreani, Anthony A. ; Von Essen, Susanna G. ; Sisson, Joseph H. ; Hill, Gary E. ; Rubinstein, Israel ; Townley, Robert G. / Measurement of exhaled nitric oxide by three different techniques. In: American Journal of Respiratory and Critical Care Medicine. 1996 ; Vol. 153, No. 5. pp. 1631-1635.
@article{e184aca371774b4b92e5ed873359c107,
title = "Measurement of exhaled nitric oxide by three different techniques",
abstract = "The purpose of the study was to compare exhaled nitric oxide (NO) determined by three techniques. Ninety-one subjects performed a slow vital capacity maneuver: (1) through the mouth directly into a NO chemiluminescence analyzer (peak oral NO), (2) through the mouth into a collection bag (mean oral NO), and (3) through the nose into a collection bag (mean nasal NO). Peak oral NO was higher in patients with asthma (n = 18, 174.2 ± 27.0 ppb), but lower in smokers (n = 36, 39.6 ± 4.8 ppb) compared with nonsmoking control subjects (n = 23, 105.5 ± 8.4 ppb, p <0.05 both comparisons). Mean oral NO levels were significantly lower than peak oral NO levels (p <0.05), but still higher in patients with asthma in comparison with nonsmoking healthy control subjects and asymptomatic smokers (27.2 ± 3.5 versus 14.5 ± 1.1 and 7.3 ± 0.7 ppb, respectively, p <0.05). In contrast, there was no significant difference in mean nasal NO levels between the three groups. Peak oral NO and mean oral NO levels correlated (r = 0.772, p <0.0001). Determination of exhaled oral NO levels is qualitatively independent of the technique used, but nasal exhalation may affect NO determination in conditions associated with airway inflammation.",
author = "Robbins, {Richard A.} and Floreani, {Anthony A.} and {Von Essen}, {Susanna G.} and Sisson, {Joseph H.} and Hill, {Gary E.} and Israel Rubinstein and Townley, {Robert G.}",
year = "1996",
language = "English",
volume = "153",
pages = "1631--1635",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "5",

}

TY - JOUR

T1 - Measurement of exhaled nitric oxide by three different techniques

AU - Robbins, Richard A.

AU - Floreani, Anthony A.

AU - Von Essen, Susanna G.

AU - Sisson, Joseph H.

AU - Hill, Gary E.

AU - Rubinstein, Israel

AU - Townley, Robert G.

PY - 1996

Y1 - 1996

N2 - The purpose of the study was to compare exhaled nitric oxide (NO) determined by three techniques. Ninety-one subjects performed a slow vital capacity maneuver: (1) through the mouth directly into a NO chemiluminescence analyzer (peak oral NO), (2) through the mouth into a collection bag (mean oral NO), and (3) through the nose into a collection bag (mean nasal NO). Peak oral NO was higher in patients with asthma (n = 18, 174.2 ± 27.0 ppb), but lower in smokers (n = 36, 39.6 ± 4.8 ppb) compared with nonsmoking control subjects (n = 23, 105.5 ± 8.4 ppb, p <0.05 both comparisons). Mean oral NO levels were significantly lower than peak oral NO levels (p <0.05), but still higher in patients with asthma in comparison with nonsmoking healthy control subjects and asymptomatic smokers (27.2 ± 3.5 versus 14.5 ± 1.1 and 7.3 ± 0.7 ppb, respectively, p <0.05). In contrast, there was no significant difference in mean nasal NO levels between the three groups. Peak oral NO and mean oral NO levels correlated (r = 0.772, p <0.0001). Determination of exhaled oral NO levels is qualitatively independent of the technique used, but nasal exhalation may affect NO determination in conditions associated with airway inflammation.

AB - The purpose of the study was to compare exhaled nitric oxide (NO) determined by three techniques. Ninety-one subjects performed a slow vital capacity maneuver: (1) through the mouth directly into a NO chemiluminescence analyzer (peak oral NO), (2) through the mouth into a collection bag (mean oral NO), and (3) through the nose into a collection bag (mean nasal NO). Peak oral NO was higher in patients with asthma (n = 18, 174.2 ± 27.0 ppb), but lower in smokers (n = 36, 39.6 ± 4.8 ppb) compared with nonsmoking control subjects (n = 23, 105.5 ± 8.4 ppb, p <0.05 both comparisons). Mean oral NO levels were significantly lower than peak oral NO levels (p <0.05), but still higher in patients with asthma in comparison with nonsmoking healthy control subjects and asymptomatic smokers (27.2 ± 3.5 versus 14.5 ± 1.1 and 7.3 ± 0.7 ppb, respectively, p <0.05). In contrast, there was no significant difference in mean nasal NO levels between the three groups. Peak oral NO and mean oral NO levels correlated (r = 0.772, p <0.0001). Determination of exhaled oral NO levels is qualitatively independent of the technique used, but nasal exhalation may affect NO determination in conditions associated with airway inflammation.

UR - http://www.scopus.com/inward/record.url?scp=0029940578&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029940578&partnerID=8YFLogxK

M3 - Article

C2 - 8630613

AN - SCOPUS:0029940578

VL - 153

SP - 1631

EP - 1635

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 5

ER -