Mechanotransduction in neutrophil activation and deactivation

Andrew Ekpenyong, Nicole Toepfner, Edwin R. Chilvers, Jochen Guck

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Mechanotransduction refers to the processes through which cells sense mechanical stimuli by converting them to biochemical signals and, thus, eliciting specific cellular responses. Cells sense mechanical stimuli from their 3D environment, including the extracellular matrix, neighboring cells and other mechanical forces. Incidentally, the emerging concept of mechanical homeostasis,long term or chronic regulation of mechanical properties, seems to apply to neutrophils in a peculiar manner, owing to neutrophils' ability to dynamically switch between the activated/primed and deactivated/deprimed states. While neutrophil activation has been known for over a century, its deactivation is a relatively recent discovery. Even more intriguing is the reversibility of neutrophil activation and deactivation. We review and critically evaluate recent findings that suggest physiological roles for neutrophil activation and deactivation and discuss possible mechanisms by which mechanical stimuli can drive the oscillation of neutrophils between the activated and resting states. We highlight several molecules that have been identified in neutrophil mechanotransduction, including cell adhesion and transmembrane receptors, cytoskeletal and ion channel molecules. The physiological and pathophysiological implications of such mechanically induced signal transduction in neutrophils are highlighted as a basis for future work. This article is part of a Special Issue entitled: Mechanobiology.

Original languageEnglish
Pages (from-to)3105-3116
Number of pages12
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1853
Issue number11
DOIs
StatePublished - Nov 1 2015

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Neutrophil Activation
Neutrophils
Mechanical Phenomena
Biophysics
Ion Channels
Cell Adhesion
Extracellular Matrix
Signal Transduction
Homeostasis

All Science Journal Classification (ASJC) codes

  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

Mechanotransduction in neutrophil activation and deactivation. / Ekpenyong, Andrew; Toepfner, Nicole; Chilvers, Edwin R.; Guck, Jochen.

In: Biochimica et Biophysica Acta - Molecular Cell Research, Vol. 1853, No. 11, 01.11.2015, p. 3105-3116.

Research output: Contribution to journalArticle

Ekpenyong, Andrew ; Toepfner, Nicole ; Chilvers, Edwin R. ; Guck, Jochen. / Mechanotransduction in neutrophil activation and deactivation. In: Biochimica et Biophysica Acta - Molecular Cell Research. 2015 ; Vol. 1853, No. 11. pp. 3105-3116.
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