Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D

Cedric F. Garland, June Jiwon Kim, Sharif Burgette Mohr, Edward Doerr Gorham, William B. Grant, Edward L. Giovannucci, Leo Baggerly, Heather Hofflich, Joe Wesley Ramsdell, Kenneth Zeng, Robert P. Heaney

Research output: Contribution to journalReview article

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Abstract

We examined the relationship between serum 25-hydroxyvitaminD(25[OH]D) and all-cause mortality. We searched biomedical databases for articles that assessed 2 ormore categories of 25(OH)D from January 1, 1966, to January 15, 2013. We identified 32 studies and pooled the data. The hazard ratio for allcause mortality comparing the lowest (0-9 nanograms per milliliter [ng/mL]) to the highest (> 30 ng/mL) category of 25(OH)D was 1.9 (95% confidence interval = 1.6, 2.2; P <.001). Serum 25 (OH)D concentrations less than or equal to 30 ng/mL were associated with higher all-causemortality than concentrations greater than 30 ng/mL (P <.01). Our findings agree with a National Academy of Sciences report, except the cutoff point for all-cause mortality reduction in this analysis was greater than 30 ng/mL rather than greater than 20 ng/mL.

Original languageEnglish
JournalAmerican Journal of Public Health
Volume104
Issue number8
DOIs
StatePublished - 2014

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Meta-Analysis
Mortality
Serum
Databases
Confidence Intervals
25-hydroxyvitamin D

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Garland, C. F., Kim, J. J., Mohr, S. B., Gorham, E. D., Grant, W. B., Giovannucci, E. L., ... Heaney, R. P. (2014). Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D. American Journal of Public Health, 104(8). https://doi.org/10.2105/AJPH.2014.302034

Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D. / Garland, Cedric F.; Kim, June Jiwon; Mohr, Sharif Burgette; Gorham, Edward Doerr; Grant, William B.; Giovannucci, Edward L.; Baggerly, Leo; Hofflich, Heather; Ramsdell, Joe Wesley; Zeng, Kenneth; Heaney, Robert P.

In: American Journal of Public Health, Vol. 104, No. 8, 2014.

Research output: Contribution to journalReview article

Garland, CF, Kim, JJ, Mohr, SB, Gorham, ED, Grant, WB, Giovannucci, EL, Baggerly, L, Hofflich, H, Ramsdell, JW, Zeng, K & Heaney, RP 2014, 'Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D', American Journal of Public Health, vol. 104, no. 8. https://doi.org/10.2105/AJPH.2014.302034
Garland, Cedric F. ; Kim, June Jiwon ; Mohr, Sharif Burgette ; Gorham, Edward Doerr ; Grant, William B. ; Giovannucci, Edward L. ; Baggerly, Leo ; Hofflich, Heather ; Ramsdell, Joe Wesley ; Zeng, Kenneth ; Heaney, Robert P. / Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D. In: American Journal of Public Health. 2014 ; Vol. 104, No. 8.
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