Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D

Cedric F. Garland; June Jiwon Kim; Sharif Burgette Mohr; Edward Doerr Gorham; William B. Grant; Edward L. Giovannucci; Leo Baggerly; Heather Hofflich; Joe Wesley Ramsdell; Kenneth Zeng; Robert P. Heaney

doi:10.2105/AJPH.2014.302034

Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D

Cedric F. Garland, June Jiwon Kim, Sharif Burgette Mohr, Edward Doerr Gorham, William B. Grant, Edward L. Giovannucci, Leo Baggerly, Heather Hofflich, Joe Wesley Ramsdell, Kenneth Zeng, Robert P. Heaney

Department of Medicine

Research output: Contribution to journal › Review article

99 Scopus citations

Abstract

We examined the relationship between serum 25-hydroxyvitaminD(25[OH]D) and all-cause mortality. We searched biomedical databases for articles that assessed 2 ormore categories of 25(OH)D from January 1, 1966, to January 15, 2013. We identified 32 studies and pooled the data. The hazard ratio for allcause mortality comparing the lowest (0-9 nanograms per milliliter [ng/mL]) to the highest (> 30 ng/mL) category of 25(OH)D was 1.9 (95% confidence interval = 1.6, 2.2; P <.001). Serum 25 (OH)D concentrations less than or equal to 30 ng/mL were associated with higher all-causemortality than concentrations greater than 30 ng/mL (P <.01). Our findings agree with a National Academy of Sciences report, except the cutoff point for all-cause mortality reduction in this analysis was greater than 30 ng/mL rather than greater than 20 ng/mL.

Original language	English (US)
Pages (from-to)	e43-e50
Journal	American Journal of Public Health
Volume	104
Issue number	8
DOIs	https://doi.org/10.2105/AJPH.2014.302034
State	Published - Aug 2014

All Science Journal Classification (ASJC) codes

Public Health, Environmental and Occupational Health

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10.2105/AJPH.2014.302034

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Garland, C. F., Kim, J. J., Mohr, S. B., Gorham, E. D., Grant, W. B., Giovannucci, E. L., Baggerly, L., Hofflich, H., Ramsdell, J. W., Zeng, K., & Heaney, R. P. (2014). Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D. American Journal of Public Health, 104(8), e43-e50. https://doi.org/10.2105/AJPH.2014.302034

Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D. / Garland, Cedric F.; Kim, June Jiwon; Mohr, Sharif Burgette; Gorham, Edward Doerr; Grant, William B.; Giovannucci, Edward L.; Baggerly, Leo; Hofflich, Heather; Ramsdell, Joe Wesley; Zeng, Kenneth; Heaney, Robert P.

In: American Journal of Public Health, Vol. 104, No. 8, 08.2014, p. e43-e50.

Research output: Contribution to journal › Review article

Garland, Cedric F. ; Kim, June Jiwon ; Mohr, Sharif Burgette ; Gorham, Edward Doerr ; Grant, William B. ; Giovannucci, Edward L. ; Baggerly, Leo ; Hofflich, Heather ; Ramsdell, Joe Wesley ; Zeng, Kenneth ; Heaney, Robert P. / Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D. In: American Journal of Public Health. 2014 ; Vol. 104, No. 8. pp. e43-e50.

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abstract = "We examined the relationship between serum 25-hydroxyvitaminD(25[OH]D) and all-cause mortality. We searched biomedical databases for articles that assessed 2 ormore categories of 25(OH)D from January 1, 1966, to January 15, 2013. We identified 32 studies and pooled the data. The hazard ratio for allcause mortality comparing the lowest (0-9 nanograms per milliliter [ng/mL]) to the highest (> 30 ng/mL) category of 25(OH)D was 1.9 (95% confidence interval = 1.6, 2.2; P <.001). Serum 25 (OH)D concentrations less than or equal to 30 ng/mL were associated with higher all-causemortality than concentrations greater than 30 ng/mL (P <.01). Our findings agree with a National Academy of Sciences report, except the cutoff point for all-cause mortality reduction in this analysis was greater than 30 ng/mL rather than greater than 20 ng/mL.",

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