Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D

Cedric F. Garland, June Jiwon Kim, Sharif Burgette Mohr, Edward Doerr Gorham, William B. Grant, Edward L. Giovannucci, Leo Baggerly, Heather Hofflich, Joe Wesley Ramsdell, Kenneth Zeng, Robert P. Heaney

Research output: Contribution to journalReview articlepeer-review

126 Scopus citations


We examined the relationship between serum 25-hydroxyvitaminD(25[OH]D) and all-cause mortality. We searched biomedical databases for articles that assessed 2 ormore categories of 25(OH)D from January 1, 1966, to January 15, 2013. We identified 32 studies and pooled the data. The hazard ratio for allcause mortality comparing the lowest (0-9 nanograms per milliliter [ng/mL]) to the highest (> 30 ng/mL) category of 25(OH)D was 1.9 (95% confidence interval = 1.6, 2.2; P <.001). Serum 25 (OH)D concentrations less than or equal to 30 ng/mL were associated with higher all-causemortality than concentrations greater than 30 ng/mL (P <.01). Our findings agree with a National Academy of Sciences report, except the cutoff point for all-cause mortality reduction in this analysis was greater than 30 ng/mL rather than greater than 20 ng/mL.

Original languageEnglish (US)
Pages (from-to)e43-e50
JournalAmerican Journal of Public Health
Issue number8
StatePublished - Aug 2014

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health


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