Abstract
We examined the relationship between serum 25-hydroxyvitaminD(25[OH]D) and all-cause mortality. We searched biomedical databases for articles that assessed 2 ormore categories of 25(OH)D from January 1, 1966, to January 15, 2013. We identified 32 studies and pooled the data. The hazard ratio for allcause mortality comparing the lowest (0-9 nanograms per milliliter [ng/mL]) to the highest (> 30 ng/mL) category of 25(OH)D was 1.9 (95% confidence interval = 1.6, 2.2; P <.001). Serum 25 (OH)D concentrations less than or equal to 30 ng/mL were associated with higher all-causemortality than concentrations greater than 30 ng/mL (P <.01). Our findings agree with a National Academy of Sciences report, except the cutoff point for all-cause mortality reduction in this analysis was greater than 30 ng/mL rather than greater than 20 ng/mL.
| Original language | English |
|---|---|
| Journal | American Journal of Public Health |
| Volume | 104 |
| Issue number | 8 |
| DOIs | |
| State | Published - 2014 |
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All Science Journal Classification (ASJC) codes
- Public Health, Environmental and Occupational Health
Cite this
Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D. / Garland, Cedric F.; Kim, June Jiwon; Mohr, Sharif Burgette; Gorham, Edward Doerr; Grant, William B.; Giovannucci, Edward L.; Baggerly, Leo; Hofflich, Heather; Ramsdell, Joe Wesley; Zeng, Kenneth; Heaney, Robert P.
In: American Journal of Public Health, Vol. 104, No. 8, 2014.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D
AU - Garland, Cedric F.
AU - Kim, June Jiwon
AU - Mohr, Sharif Burgette
AU - Gorham, Edward Doerr
AU - Grant, William B.
AU - Giovannucci, Edward L.
AU - Baggerly, Leo
AU - Hofflich, Heather
AU - Ramsdell, Joe Wesley
AU - Zeng, Kenneth
AU - Heaney, Robert P.
PY - 2014
Y1 - 2014
N2 - We examined the relationship between serum 25-hydroxyvitaminD(25[OH]D) and all-cause mortality. We searched biomedical databases for articles that assessed 2 ormore categories of 25(OH)D from January 1, 1966, to January 15, 2013. We identified 32 studies and pooled the data. The hazard ratio for allcause mortality comparing the lowest (0-9 nanograms per milliliter [ng/mL]) to the highest (> 30 ng/mL) category of 25(OH)D was 1.9 (95% confidence interval = 1.6, 2.2; P <.001). Serum 25 (OH)D concentrations less than or equal to 30 ng/mL were associated with higher all-causemortality than concentrations greater than 30 ng/mL (P <.01). Our findings agree with a National Academy of Sciences report, except the cutoff point for all-cause mortality reduction in this analysis was greater than 30 ng/mL rather than greater than 20 ng/mL.
AB - We examined the relationship between serum 25-hydroxyvitaminD(25[OH]D) and all-cause mortality. We searched biomedical databases for articles that assessed 2 ormore categories of 25(OH)D from January 1, 1966, to January 15, 2013. We identified 32 studies and pooled the data. The hazard ratio for allcause mortality comparing the lowest (0-9 nanograms per milliliter [ng/mL]) to the highest (> 30 ng/mL) category of 25(OH)D was 1.9 (95% confidence interval = 1.6, 2.2; P <.001). Serum 25 (OH)D concentrations less than or equal to 30 ng/mL were associated with higher all-causemortality than concentrations greater than 30 ng/mL (P <.01). Our findings agree with a National Academy of Sciences report, except the cutoff point for all-cause mortality reduction in this analysis was greater than 30 ng/mL rather than greater than 20 ng/mL.
UR - http://www.scopus.com/inward/record.url?scp=84904316965&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84904316965&partnerID=8YFLogxK
U2 - 10.2105/AJPH.2014.302034
DO - 10.2105/AJPH.2014.302034
M3 - Review article
C2 - 24922127
AN - SCOPUS:84904316965
VL - 104
JO - American Journal of Public Health
JF - American Journal of Public Health
SN - 0090-0036
IS - 8
ER -