Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D

Cedric F. Garland, June Jiwon Kim, Sharif Burgette Mohr, Edward Doerr Gorham, William B. Grant, Edward L. Giovannucci, Leo Baggerly, Heather Hofflich, Joe Wesley Ramsdell, Kenneth Zeng, Robert P. Heaney

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Abstract

We examined the relationship between serum 25-hydroxyvitaminD(25[OH]D) and all-cause mortality. We searched biomedical databases for articles that assessed 2 ormore categories of 25(OH)D from January 1, 1966, to January 15, 2013. We identified 32 studies and pooled the data. The hazard ratio for allcause mortality comparing the lowest (0-9 nanograms per milliliter [ng/mL]) to the highest (> 30 ng/mL) category of 25(OH)D was 1.9 (95% confidence interval = 1.6, 2.2; P <.001). Serum 25 (OH)D concentrations less than or equal to 30 ng/mL were associated with higher all-causemortality than concentrations greater than 30 ng/mL (P <.01). Our findings agree with a National Academy of Sciences report, except the cutoff point for all-cause mortality reduction in this analysis was greater than 30 ng/mL rather than greater than 20 ng/mL.

Original languageEnglish (US)
Pages (from-to)e43-e50
JournalAmerican Journal of Public Health
Volume104
Issue number8
DOIs
StatePublished - Aug 2014

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

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    Garland, C. F., Kim, J. J., Mohr, S. B., Gorham, E. D., Grant, W. B., Giovannucci, E. L., Baggerly, L., Hofflich, H., Ramsdell, J. W., Zeng, K., & Heaney, R. P. (2014). Meta-analysis of all-cause mortality according to serum 25-hydroxyvitamin D. American Journal of Public Health, 104(8), e43-e50. https://doi.org/10.2105/AJPH.2014.302034