We examined the relationship between serum 25-hydroxyvitaminD(25[OH]D) and all-cause mortality. We searched biomedical databases for articles that assessed 2 ormore categories of 25(OH)D from January 1, 1966, to January 15, 2013. We identified 32 studies and pooled the data. The hazard ratio for allcause mortality comparing the lowest (0-9 nanograms per milliliter [ng/mL]) to the highest (> 30 ng/mL) category of 25(OH)D was 1.9 (95% confidence interval = 1.6, 2.2; P <.001). Serum 25 (OH)D concentrations less than or equal to 30 ng/mL were associated with higher all-causemortality than concentrations greater than 30 ng/mL (P <.01). Our findings agree with a National Academy of Sciences report, except the cutoff point for all-cause mortality reduction in this analysis was greater than 30 ng/mL rather than greater than 20 ng/mL.
All Science Journal Classification (ASJC) codes
- Public Health, Environmental and Occupational Health