Meta-analysis of genome-wide association data identifies two loci influencing age at menarche

John R B Perry, Lisette Stolk, Nora Franceschini, Kathryn L. Lunetta, Guangju Zhai, Patrick F. McArdle, Albert V. Smith, Thor Aspelund, Stefania Bandinelli, Eric Boerwinkle, Lynn Cherkas, Gudny Eiriksdottir, Karol Estrada, Luigi Ferrucci, Aaron R. Folsom, Melissa Garcia, Vilmundur Gudnason, Albert Hofman, David Karasik, Douglas P. Kiel & 19 others Lenore J. Launer, Joyce Van Meurs, Michael A. Nalls, Fernando Rivadeneira, Alan R. Shuldiner, Andrew Singleton, Nicole Soranzo, Toshiko Tanaka, Jenny A. Visser, Michael N. Weedon, Scott G. Wilson, Vivian Zhuang, Elizabeth A. Streeten, Tamara B. Harris, Anna Murray, Tim D. Spector, Ellen W. Demerath, André G. Uitterlinden, Joanne M. Murabito

Research output: Contribution to journalArticle

188 Citations (Scopus)

Abstract

We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10 9), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10 9), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.

Original languageEnglish
Pages (from-to)648-650
Number of pages3
JournalNature Genetics
Volume41
Issue number6
DOIs
StatePublished - Jun 2009
Externally publishedYes

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Menarche
Meta-Analysis
Genome
Genes
Sexual Maturation

All Science Journal Classification (ASJC) codes

  • Genetics
  • Medicine(all)

Cite this

Perry, J. R. B., Stolk, L., Franceschini, N., Lunetta, K. L., Zhai, G., McArdle, P. F., ... Murabito, J. M. (2009). Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nature Genetics, 41(6), 648-650. https://doi.org/10.1038/ng.386

Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. / Perry, John R B; Stolk, Lisette; Franceschini, Nora; Lunetta, Kathryn L.; Zhai, Guangju; McArdle, Patrick F.; Smith, Albert V.; Aspelund, Thor; Bandinelli, Stefania; Boerwinkle, Eric; Cherkas, Lynn; Eiriksdottir, Gudny; Estrada, Karol; Ferrucci, Luigi; Folsom, Aaron R.; Garcia, Melissa; Gudnason, Vilmundur; Hofman, Albert; Karasik, David; Kiel, Douglas P.; Launer, Lenore J.; Van Meurs, Joyce; Nalls, Michael A.; Rivadeneira, Fernando; Shuldiner, Alan R.; Singleton, Andrew; Soranzo, Nicole; Tanaka, Toshiko; Visser, Jenny A.; Weedon, Michael N.; Wilson, Scott G.; Zhuang, Vivian; Streeten, Elizabeth A.; Harris, Tamara B.; Murray, Anna; Spector, Tim D.; Demerath, Ellen W.; Uitterlinden, André G.; Murabito, Joanne M.

In: Nature Genetics, Vol. 41, No. 6, 06.2009, p. 648-650.

Research output: Contribution to journalArticle

Perry, JRB, Stolk, L, Franceschini, N, Lunetta, KL, Zhai, G, McArdle, PF, Smith, AV, Aspelund, T, Bandinelli, S, Boerwinkle, E, Cherkas, L, Eiriksdottir, G, Estrada, K, Ferrucci, L, Folsom, AR, Garcia, M, Gudnason, V, Hofman, A, Karasik, D, Kiel, DP, Launer, LJ, Van Meurs, J, Nalls, MA, Rivadeneira, F, Shuldiner, AR, Singleton, A, Soranzo, N, Tanaka, T, Visser, JA, Weedon, MN, Wilson, SG, Zhuang, V, Streeten, EA, Harris, TB, Murray, A, Spector, TD, Demerath, EW, Uitterlinden, AG & Murabito, JM 2009, 'Meta-analysis of genome-wide association data identifies two loci influencing age at menarche', Nature Genetics, vol. 41, no. 6, pp. 648-650. https://doi.org/10.1038/ng.386
Perry JRB, Stolk L, Franceschini N, Lunetta KL, Zhai G, McArdle PF et al. Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nature Genetics. 2009 Jun;41(6):648-650. https://doi.org/10.1038/ng.386
Perry, John R B ; Stolk, Lisette ; Franceschini, Nora ; Lunetta, Kathryn L. ; Zhai, Guangju ; McArdle, Patrick F. ; Smith, Albert V. ; Aspelund, Thor ; Bandinelli, Stefania ; Boerwinkle, Eric ; Cherkas, Lynn ; Eiriksdottir, Gudny ; Estrada, Karol ; Ferrucci, Luigi ; Folsom, Aaron R. ; Garcia, Melissa ; Gudnason, Vilmundur ; Hofman, Albert ; Karasik, David ; Kiel, Douglas P. ; Launer, Lenore J. ; Van Meurs, Joyce ; Nalls, Michael A. ; Rivadeneira, Fernando ; Shuldiner, Alan R. ; Singleton, Andrew ; Soranzo, Nicole ; Tanaka, Toshiko ; Visser, Jenny A. ; Weedon, Michael N. ; Wilson, Scott G. ; Zhuang, Vivian ; Streeten, Elizabeth A. ; Harris, Tamara B. ; Murray, Anna ; Spector, Tim D. ; Demerath, Ellen W. ; Uitterlinden, André G. ; Murabito, Joanne M. / Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. In: Nature Genetics. 2009 ; Vol. 41, No. 6. pp. 648-650.
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