Metabolic bone disease in alcoholic cirrhosis

A comparison of the effect of vitamin D2, 25-hydroxyvitamin D, or supportive treatment

S. A. Mobarhan, R. M. Russell, Robert R. Recker, D. B. Posner, F. L. Iber, P. Miller

Research output: Contribution to journalArticle

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Abstract

In a study of 56 alcoholics with liver cirrhosis, 18 (32%) had decreased bone density and low levels of serum 25-hydroxyvitamin D (25-OH-D) (2 and 25-OH-D treatment in correcting the metabolic bone disease in alcoholic cirrhosis, the 18 patients were randomized in the following manner, in groups of 6 patients each: Group 1, control (received no supplemental vitamin D treatment); Group 2, given vitamin D2 (50,000 IU p.o.) two to three times weekly, and Group 3, treated with 25-OH-D (20 to 50 mg p.o.) daily as required to attain normal serum 25-OH-D levels. The study period lasted 6 to 12 months (mean, 10.7 months). Initial histomorphometric study of transiliac bone biopsy with double tetracycline labeling in 9 patients in whom biopsy was feasible showed only osteoporosis without evidence of osteomalacia. By the end of the study, serum 25-OH-D levels in the control group (Group 1) raised slightly while showing marked improvement in Groups 2 and 3. Bone density results remained unchanged in control patients but demonstrated a significant increase in both treatment groups. Vitamin D2 and 25-OH-D were equally effective in increasing bone density measurements. Posttreatment biopsies were performed in 3 patients of Group 2 and 2 patients of Group 3. While the histomorphometric results in Group 3 were not conclusive, in Group 2 improvement in static measures of bone remodeling was noted. Osteoporosis is the usual form of bone disease in alcoholic cirrhosis and a response to either vitamin D2 or 25-OH-D treatment is suggested.

Original languageEnglish
Pages (from-to)266-273
Number of pages8
JournalHepatology
Volume4
Issue number2
StatePublished - 1984

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Ergocalciferols
Alcoholic Liver Cirrhosis
Metabolic Bone Diseases
Bone Density
Biopsy
Therapeutics
Osteoporosis
Serum
Osteomalacia
Control Groups
Bone Remodeling
Bone Diseases
25-hydroxyvitamin D
hydroxide ion
Tetracycline
Vitamin D
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Hepatology

Cite this

Metabolic bone disease in alcoholic cirrhosis : A comparison of the effect of vitamin D2, 25-hydroxyvitamin D, or supportive treatment. / Mobarhan, S. A.; Russell, R. M.; Recker, Robert R.; Posner, D. B.; Iber, F. L.; Miller, P.

In: Hepatology, Vol. 4, No. 2, 1984, p. 266-273.

Research output: Contribution to journalArticle

Mobarhan, S. A. ; Russell, R. M. ; Recker, Robert R. ; Posner, D. B. ; Iber, F. L. ; Miller, P. / Metabolic bone disease in alcoholic cirrhosis : A comparison of the effect of vitamin D2, 25-hydroxyvitamin D, or supportive treatment. In: Hepatology. 1984 ; Vol. 4, No. 2. pp. 266-273.
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