Metabolic Bone Disease in Alcoholic Cirrhosis: A Comparison of the Effect of Vitamin D2 25‐Hydroxyvitamin D, or Supportive Treatment

Sohrab A. Mobarhan, Robert M. Russell, Robert R. Recker, David B. Posner, Frank L. Iber, Pamela Miller

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

In a study of 56 alcoholics with liver cirrhosis, 18 (32%) had decreased bone density and low levels of serum 25-hydroxyvitamin D (25-OH-D) (2 and 25-OH-D treatment in correcting the metabolic bone disease in alcoholic cirrhosis, the 18 patients were randomized in the following manner, in groups of 6 patients each: Group 1, control (received no supplemental vitamin D treatment); Group 2, given vitamin D2 (50,000 IU p.o.) two to three times weekly, and Group 3, treated with 25-OH-D (20 to 50 mg p.o.) daily as required to attain normal serum 25-OH-D levels. The study period lasted 6 to 12 months (mean, 10.7 months). Initial histomorphometric study of transiliac bone biopsy with double tetracycline labeling in 9 patients in whom biopsy was feasible showed only osteoporosis without evidence of osteomalacia. By the end of the study, serum 25-OH-D levels in the control group (Group 1) raised slightly while showing marked improvement in Groups 2 and 3. Bone density results remained unchanged in control patients but demonstrated a significant increase in both treatment groups. Vitamin D2 and 25-OH-D were equally effective in increasing bone density measurements. Posttreatment biopsies were performed in 3 patients of Group 2 and 2 patients of Group 3. While the histomorphometric results in Group 3 were not conclusive, in Group 2 improvement in static measures of bone remodeling was noted. Osteoporosis is the usual form of bone disease in alcoholic cirrhosis and a response to either vitamin D2 or 25-OH-D treatment is suggested.

Original languageEnglish (US)
Pages (from-to)266-273
Number of pages8
JournalHepatology
Volume4
Issue number2
DOIs
StatePublished - Jan 1 1984

All Science Journal Classification (ASJC) codes

  • Hepatology

Fingerprint Dive into the research topics of 'Metabolic Bone Disease in Alcoholic Cirrhosis: A Comparison of the Effect of Vitamin D<sub>2</sub> 25‐Hydroxyvitamin D, or Supportive Treatment'. Together they form a unique fingerprint.

  • Cite this