Methacholine inhalation challenge studies in a selcted pediatric population

R. J. Hopp, Againdra K. Bewtra, N. M. Nair, G. D. Watt, R. G. Townley

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

To determine bronchial reactivity patterns, 400 subjects, 5 to 21 yr of age, underwent a methacholine challenge in a Natural History of Asthma study. The diagnosis of asthma or allergy was based on a respiratory questionnaire. Subjects were nonsmokers and had had no respiratory infections for 1 month. Intradermal skin tests were done. The methacholine challenge response was expressed as the area beneath the dose-response curve (Area35). Fifty-five asthmatics, 113 normal subjects from normal families, 103 normal subjects from asthma families, 60 normal twins, and 69 allergic subjects without asthma were studied. Overall, 52% of nonasthmatics and 47% of nonallergic subjects had an Area35 less than 4,000 (800 breath units). There was a difference (p <0.05) in the distribution of methacholine Area35 responses in normal subjects from that in normal families compares with normal subjects from asthma families. The age of the nonasthmatic subjects had an influence on the degree of bronchial reactivity. Methacholine challenge studies in pediatric patients must be interpreted with age, personal atopic status, and family asthma history in mind.

Original languageEnglish
Pages (from-to)994-998
Number of pages5
JournalAmerican Review of Respiratory Disease
Volume134
Issue number5
StatePublished - 1986

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Methacholine Chloride
Inhalation
Asthma
Pediatrics
Population
Intradermal Tests
Skin Tests
Respiratory Tract Infections
Hypersensitivity

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Methacholine inhalation challenge studies in a selcted pediatric population. / Hopp, R. J.; Bewtra, Againdra K.; Nair, N. M.; Watt, G. D.; Townley, R. G.

In: American Review of Respiratory Disease, Vol. 134, No. 5, 1986, p. 994-998.

Research output: Contribution to journalArticle

Hopp, RJ, Bewtra, AK, Nair, NM, Watt, GD & Townley, RG 1986, 'Methacholine inhalation challenge studies in a selcted pediatric population', American Review of Respiratory Disease, vol. 134, no. 5, pp. 994-998.
Hopp, R. J. ; Bewtra, Againdra K. ; Nair, N. M. ; Watt, G. D. ; Townley, R. G. / Methacholine inhalation challenge studies in a selcted pediatric population. In: American Review of Respiratory Disease. 1986 ; Vol. 134, No. 5. pp. 994-998.
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