Microbial risk markers for childhood caries in pediatricians offices

E. Kanasi, I. Johansson, S. C. Lu, N. R. Kressin, M. E. Nunn, R. Kent, A. C.R. Tanner

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Dental caries in pre-school children has significant public health and health disparity implications. To determine microbial risk markers for this infection, this study aimed to compare the microbiota of children with early childhood caries with that of caries-free children. Plaque samples from incisors, molars, and the tongue from 195 children attending pediatricians offices were assayed by 74 DNA probes and by PCR to Streptococcus mutans. Caries-associated factors included visible plaque, child age, race, and snacking habits. Species were detected more frequently from tooth than tongue samples. Lactobacillus gasseri (p <0.01), Lactobacillus fermentum, Lactobacillus vaginalis , and S. mutans with Streptococcus sobrinus (all p <0.05) were positively associated with caries. By multifactorial analysis, the probiotic Lactobacillus acidophilus was negatively associated with caries. Prevotella nigrescens was the only species (p <0.05) significantly associated with caries by the false discovery rate. Analysis of the data suggests that selected Lactobacillus species, in addition to mutans streptococci, are risk markers for early childhood caries.

Original languageEnglish (US)
Pages (from-to)378-383
Number of pages6
JournalJournal of dental research
Volume89
Issue number4
DOIs
StatePublished - Apr 1 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

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    Kanasi, E., Johansson, I., Lu, S. C., Kressin, N. R., Nunn, M. E., Kent, R., & Tanner, A. C. R. (2010). Microbial risk markers for childhood caries in pediatricians offices. Journal of dental research, 89(4), 378-383. https://doi.org/10.1177/0022034509360010