Abstract
Dental caries in pre-school children has significant public health and health disparity implications. To determine microbial risk markers for this infection, this study aimed to compare the microbiota of children with early childhood caries with that of caries-free children. Plaque samples from incisors, molars, and the tongue from 195 children attending pediatricians offices were assayed by 74 DNA probes and by PCR to Streptococcus mutans. Caries-associated factors included visible plaque, child age, race, and snacking habits. Species were detected more frequently from tooth than tongue samples. Lactobacillus gasseri (p <0.01), Lactobacillus fermentum, Lactobacillus vaginalis , and S. mutans with Streptococcus sobrinus (all p <0.05) were positively associated with caries. By multifactorial analysis, the probiotic Lactobacillus acidophilus was negatively associated with caries. Prevotella nigrescens was the only species (p <0.05) significantly associated with caries by the false discovery rate. Analysis of the data suggests that selected Lactobacillus species, in addition to mutans streptococci, are risk markers for early childhood caries.
| Original language | English |
|---|---|
| Pages (from-to) | 378-383 |
| Number of pages | 6 |
| Journal | Journal of Dental Research |
| Volume | 89 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2010 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Dentistry(all)
Cite this
Microbial risk markers for childhood caries in pediatricians offices. / Kanasi, E.; Johansson, I.; Lu, S. C.; Kressin, N. R.; Nunn, Martha E.; Kent, R.; Tanner, A. C R.
In: Journal of Dental Research, Vol. 89, No. 4, 04.2010, p. 378-383.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Microbial risk markers for childhood caries in pediatricians offices
AU - Kanasi, E.
AU - Johansson, I.
AU - Lu, S. C.
AU - Kressin, N. R.
AU - Nunn, Martha E.
AU - Kent, R.
AU - Tanner, A. C R
PY - 2010/4
Y1 - 2010/4
N2 - Dental caries in pre-school children has significant public health and health disparity implications. To determine microbial risk markers for this infection, this study aimed to compare the microbiota of children with early childhood caries with that of caries-free children. Plaque samples from incisors, molars, and the tongue from 195 children attending pediatricians offices were assayed by 74 DNA probes and by PCR to Streptococcus mutans. Caries-associated factors included visible plaque, child age, race, and snacking habits. Species were detected more frequently from tooth than tongue samples. Lactobacillus gasseri (p <0.01), Lactobacillus fermentum, Lactobacillus vaginalis , and S. mutans with Streptococcus sobrinus (all p <0.05) were positively associated with caries. By multifactorial analysis, the probiotic Lactobacillus acidophilus was negatively associated with caries. Prevotella nigrescens was the only species (p <0.05) significantly associated with caries by the false discovery rate. Analysis of the data suggests that selected Lactobacillus species, in addition to mutans streptococci, are risk markers for early childhood caries.
AB - Dental caries in pre-school children has significant public health and health disparity implications. To determine microbial risk markers for this infection, this study aimed to compare the microbiota of children with early childhood caries with that of caries-free children. Plaque samples from incisors, molars, and the tongue from 195 children attending pediatricians offices were assayed by 74 DNA probes and by PCR to Streptococcus mutans. Caries-associated factors included visible plaque, child age, race, and snacking habits. Species were detected more frequently from tooth than tongue samples. Lactobacillus gasseri (p <0.01), Lactobacillus fermentum, Lactobacillus vaginalis , and S. mutans with Streptococcus sobrinus (all p <0.05) were positively associated with caries. By multifactorial analysis, the probiotic Lactobacillus acidophilus was negatively associated with caries. Prevotella nigrescens was the only species (p <0.05) significantly associated with caries by the false discovery rate. Analysis of the data suggests that selected Lactobacillus species, in addition to mutans streptococci, are risk markers for early childhood caries.
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U2 - 10.1177/0022034509360010
DO - 10.1177/0022034509360010
M3 - Article
VL - 89
SP - 378
EP - 383
JO - Journal of Dental Research
JF - Journal of Dental Research
SN - 0022-0345
IS - 4
ER -