Microbial risk markers for childhood caries in pediatricians offices

E. Kanasi, I. Johansson, S. C. Lu, N. R. Kressin, Martha E. Nunn, R. Kent, A. C R Tanner

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Dental caries in pre-school children has significant public health and health disparity implications. To determine microbial risk markers for this infection, this study aimed to compare the microbiota of children with early childhood caries with that of caries-free children. Plaque samples from incisors, molars, and the tongue from 195 children attending pediatricians offices were assayed by 74 DNA probes and by PCR to Streptococcus mutans. Caries-associated factors included visible plaque, child age, race, and snacking habits. Species were detected more frequently from tooth than tongue samples. Lactobacillus gasseri (p <0.01), Lactobacillus fermentum, Lactobacillus vaginalis , and S. mutans with Streptococcus sobrinus (all p <0.05) were positively associated with caries. By multifactorial analysis, the probiotic Lactobacillus acidophilus was negatively associated with caries. Prevotella nigrescens was the only species (p <0.05) significantly associated with caries by the false discovery rate. Analysis of the data suggests that selected Lactobacillus species, in addition to mutans streptococci, are risk markers for early childhood caries.

Original languageEnglish
Pages (from-to)378-383
Number of pages6
JournalJournal of Dental Research
Volume89
Issue number4
DOIs
StatePublished - Apr 2010
Externally publishedYes

Fingerprint

Streptococcus mutans
Lactobacillus
Tongue
Prevotella nigrescens
Streptococcus sobrinus
Lactobacillus fermentum
Lactobacillus acidophilus
Snacks
Microbiota
DNA Probes
Probiotics
Dental Caries
Incisor
Habits
Tooth
Public Health
Pediatricians
Polymerase Chain Reaction
Health
Infection

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Kanasi, E., Johansson, I., Lu, S. C., Kressin, N. R., Nunn, M. E., Kent, R., & Tanner, A. C. R. (2010). Microbial risk markers for childhood caries in pediatricians offices. Journal of Dental Research, 89(4), 378-383. https://doi.org/10.1177/0022034509360010

Microbial risk markers for childhood caries in pediatricians offices. / Kanasi, E.; Johansson, I.; Lu, S. C.; Kressin, N. R.; Nunn, Martha E.; Kent, R.; Tanner, A. C R.

In: Journal of Dental Research, Vol. 89, No. 4, 04.2010, p. 378-383.

Research output: Contribution to journalArticle

Kanasi, E, Johansson, I, Lu, SC, Kressin, NR, Nunn, ME, Kent, R & Tanner, ACR 2010, 'Microbial risk markers for childhood caries in pediatricians offices', Journal of Dental Research, vol. 89, no. 4, pp. 378-383. https://doi.org/10.1177/0022034509360010
Kanasi, E. ; Johansson, I. ; Lu, S. C. ; Kressin, N. R. ; Nunn, Martha E. ; Kent, R. ; Tanner, A. C R. / Microbial risk markers for childhood caries in pediatricians offices. In: Journal of Dental Research. 2010 ; Vol. 89, No. 4. pp. 378-383.
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