MicroRNA-183 family conservation and ciliated neurosensory organ expression

Marsha L. Pierce, Michael Weston, Bernd Fritzsch, Harrison W. Gabel, Gary Ruvkun, Garrett Soukup

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are an integral component of the metazoan genome and affect posttranscriptional repression of target messenger RNAs. The extreme phylogenetic conservation of certain miRNAs suggests their ancient origin and crucial function in conserved developmental processes. We demonstrate that highly conserved miRNA-183 orthologs exist in both deuterostomes and protostomes and their expression is predominant in ciliated ectodermal cells and organs. The miRNA-183 family members are expressed in vertebrate sensory hair cells, in innervated regions of invertebrate deuterostomes, and in sensilla of Drosophila and C. elegans. Thus, miRNA-183 family member expression is conserved in possibly homologous but morphologically distinct sensory cells and organs. The results suggest that miR-183 family members contribute specifically to neurosensory development or function, and that extant metazoan sensory organs are derived from cells that share genetic programs of common evolutionary origin.

Original languageEnglish
Pages (from-to)106-113
Number of pages8
JournalEvolution and Development
Volume10
Issue number1
DOIs
StatePublished - Jan 2008

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MicroRNAs
microRNA
metazoan
hair
Genome Components
RNA
cells
vertebrate
Sensilla
genome
invertebrate
sense organs
phylogenetics
sensilla
Invertebrates
messenger RNA
Drosophila
hairs
Vertebrates
invertebrates

All Science Journal Classification (ASJC) codes

  • Genetics
  • Embryology
  • Developmental Biology
  • Ecology, Evolution, Behavior and Systematics
  • Agricultural and Biological Sciences (miscellaneous)
  • Genetics(clinical)
  • Agricultural and Biological Sciences(all)

Cite this

MicroRNA-183 family conservation and ciliated neurosensory organ expression. / Pierce, Marsha L.; Weston, Michael; Fritzsch, Bernd; Gabel, Harrison W.; Ruvkun, Gary; Soukup, Garrett.

In: Evolution and Development, Vol. 10, No. 1, 01.2008, p. 106-113.

Research output: Contribution to journalArticle

Pierce, Marsha L. ; Weston, Michael ; Fritzsch, Bernd ; Gabel, Harrison W. ; Ruvkun, Gary ; Soukup, Garrett. / MicroRNA-183 family conservation and ciliated neurosensory organ expression. In: Evolution and Development. 2008 ; Vol. 10, No. 1. pp. 106-113.
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