MicroRNAs and epithelial immunity

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MicroRNAs are required for development and maintenance of the epithelial barrier. It is hypothesized that microRNAs are involved in regulating epithelial anti-microbial defenses by targeting key epithelial effector molecules and/or influencing intracellular signaling pathways. Additionally, aberrant microRNA expression has been implicated in the pathogenesis of various diseases at the skin and mucosa. Increased understanding of the role of microRNAs in epithelial immunoregulation and identification of microRNAs of pathogenetic significance will enhance our understanding of epithelial immunobiology and immunopathology.

Original languageEnglish
Pages (from-to)139-154
Number of pages16
JournalInternational Reviews of Immunology
Issue number3-4
Publication statusPublished - 2009


All Science Journal Classification (ASJC) codes

  • Immunology
  • Immunology and Allergy

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