MicroRNAs sound off

Research output: Contribution to journalShort survey

7 Citations (Scopus)

Abstract

The message is loud and clear. MicroRNA-96, one in a cluster of three related neurosensory microRNAs, is crucial to the development and maintenance of inner ear hair cells and hearing in mice and humans. Two recent studies show that mutations in the critical seed region of the microRNA underlie the cause of hair cell degeneration and progressive hearing loss. Other recent reports reveal the general requirement of microRNAs for sensory epithelial development and maintenance in Dicer knockout mouse ear. The challenge begins to determine whether microRNAs will resonate as therapeutic agents or target molecules to preserve or restore hearing.

Original languageEnglish
Article numbergm59
JournalGenome Medicine
Volume1
Issue number6
DOIs
StatePublished - Jun 8 2009

Fingerprint

MicroRNAs
Inner Auditory Hair Cells
Hearing
Maintenance
Inner Ear
Hearing Loss
Knockout Mice
Ear
Seeds
Mutation
Therapeutics

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Genetics
  • Molecular Biology
  • Molecular Medicine

Cite this

MicroRNAs sound off. / Weston, Michael; Soukup, Garrett.

In: Genome Medicine, Vol. 1, No. 6, gm59, 08.06.2009.

Research output: Contribution to journalShort survey

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