@article{5761e6c9ba7e440984ab634f47de3827,
title = "Milestones of Lynch syndrome: 1895-2015",
abstract = "Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer condition, is characterized by the predisposition to a spectrum of cancers, primarily colorectal cancer and endometrial cancer. We chronicle over a century of discoveries that revolutionized the diagnosis and clinical management of Lynch syndrome, beginning in 1895 with Warthin's observations of familial cancer clusters, through the clinical era led by Lynch and the genetic era heralded by the discovery of causative mutations in mismatch repair (MMR) genes, to ongoing challenges.",
author = "Lynch, {Henry T.} and Snyder, {Carrie L.} and Shaw, {Trudy G.} and Heinen, {Christopher D.} and Hitchins, {Megan P.}",
note = "Funding Information: This work was supported by revenue from Nebraska cigarette taxes awarded to Creighton University by the Nebraska Department of Health and Human Services. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the State of Nebraska or the Nebraska Department of Health and Human Services. H.T.L.{\textquoteright}s work is partially funded through the Charles F. and Mary C. Heider Chair in Cancer Research, which he holds at Creighton University. The Creighton work also receives funding from “Kicks for a Cure”. The authors appreciate the intense and constant help provided by LS patients and their families. This clearly has made their research possible. Publisher Copyright: {\textcopyright} 2015 Macmillan Publishers Limited. All rights reserved. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",
year = "2015",
month = feb,
day = "24",
doi = "10.1038/nrc3878",
language = "English (US)",
volume = "15",
pages = "181--194",
journal = "Nature Reviews Cancer",
issn = "1474-175X",
publisher = "Nature Publishing Group",
number = "3",
}