Milestones of Lynch syndrome: 1895-2015

Henry T. Lynch, Carrie L. Snyder, Trudy G. Shaw, Christopher D. Heinen, Megan P. Hitchins

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220 Scopus citations

Abstract

Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer condition, is characterized by the predisposition to a spectrum of cancers, primarily colorectal cancer and endometrial cancer. We chronicle over a century of discoveries that revolutionized the diagnosis and clinical management of Lynch syndrome, beginning in 1895 with Warthin's observations of familial cancer clusters, through the clinical era led by Lynch and the genetic era heralded by the discovery of causative mutations in mismatch repair (MMR) genes, to ongoing challenges.

Original languageEnglish
Pages (from-to)181-194
Number of pages14
JournalNature Reviews Cancer
Volume15
Issue number3
DOIs
Publication statusPublished - Feb 24 2015

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All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Lynch, H. T., Snyder, C. L., Shaw, T. G., Heinen, C. D., & Hitchins, M. P. (2015). Milestones of Lynch syndrome: 1895-2015. Nature Reviews Cancer, 15(3), 181-194. https://doi.org/10.1038/nrc3878