Milestones of Lynch syndrome: 1895-2015

Henry T. Lynch, Carrie L. Snyder, Trudy G. Shaw, Christopher D. Heinen, Megan P. Hitchins

Research output: Contribution to journalArticlepeer-review

451 Scopus citations


Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer condition, is characterized by the predisposition to a spectrum of cancers, primarily colorectal cancer and endometrial cancer. We chronicle over a century of discoveries that revolutionized the diagnosis and clinical management of Lynch syndrome, beginning in 1895 with Warthin's observations of familial cancer clusters, through the clinical era led by Lynch and the genetic era heralded by the discovery of causative mutations in mismatch repair (MMR) genes, to ongoing challenges.

Original languageEnglish (US)
Pages (from-to)181-194
Number of pages14
JournalNature Reviews Cancer
Issue number3
StatePublished - Feb 24 2015

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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