Abstract
Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer condition, is characterized by the predisposition to a spectrum of cancers, primarily colorectal cancer and endometrial cancer. We chronicle over a century of discoveries that revolutionized the diagnosis and clinical management of Lynch syndrome, beginning in 1895 with Warthin's observations of familial cancer clusters, through the clinical era led by Lynch and the genetic era heralded by the discovery of causative mutations in mismatch repair (MMR) genes, to ongoing challenges.
| Original language | English |
|---|---|
| Pages (from-to) | 181-194 |
| Number of pages | 14 |
| Journal | Nature Reviews Cancer |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 24 2015 |
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All Science Journal Classification (ASJC) codes
- Cancer Research
- Oncology
- Medicine(all)
Cite this
Milestones of Lynch syndrome : 1895-2015. / Lynch, Henry T.; Snyder, Carrie L.; Shaw, Trudy G.; Heinen, Christopher D.; Hitchins, Megan P.
In: Nature Reviews Cancer, Vol. 15, No. 3, 24.02.2015, p. 181-194.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Milestones of Lynch syndrome
T2 - 1895-2015
AU - Lynch, Henry T.
AU - Snyder, Carrie L.
AU - Shaw, Trudy G.
AU - Heinen, Christopher D.
AU - Hitchins, Megan P.
PY - 2015/2/24
Y1 - 2015/2/24
N2 - Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer condition, is characterized by the predisposition to a spectrum of cancers, primarily colorectal cancer and endometrial cancer. We chronicle over a century of discoveries that revolutionized the diagnosis and clinical management of Lynch syndrome, beginning in 1895 with Warthin's observations of familial cancer clusters, through the clinical era led by Lynch and the genetic era heralded by the discovery of causative mutations in mismatch repair (MMR) genes, to ongoing challenges.
AB - Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer condition, is characterized by the predisposition to a spectrum of cancers, primarily colorectal cancer and endometrial cancer. We chronicle over a century of discoveries that revolutionized the diagnosis and clinical management of Lynch syndrome, beginning in 1895 with Warthin's observations of familial cancer clusters, through the clinical era led by Lynch and the genetic era heralded by the discovery of causative mutations in mismatch repair (MMR) genes, to ongoing challenges.
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U2 - 10.1038/nrc3878
DO - 10.1038/nrc3878
M3 - Article
C2 - 25673086
AN - SCOPUS:84923585166
VL - 15
SP - 181
EP - 194
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
SN - 1474-175X
IS - 3
ER -