Moderate wine consumption is associated with decreased odds of developing age-related macular degeneration in NHANES-1

Thomas O. Obisesan, Robert Hirsch, Omofolasade Kosoko-Lasaki, Letitia Carlson, Marian Parrott

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

OBJECTIVE: To determine the association between alcohol intake and the risk of developing age-related macular degeneration (AMD). DESIGN: Case control study. PARTICIPANTS: The sample consisted of 3072 adults 45 to 74 years of age with macular changes indicative of AMD who participated in a nationally representative sample of the first National Health Nutrition and Examination Survey (NHANES-1) between 1971 and 1975: (a) the ophthalmology data set and (b) the medical history questionnaire. MAIN OUTCOME MEASURES: Alcohol intake and the risk of developing AMD were measured. AMD was determined by staff at the National Eye Institute by fundoscopy examination using standardized protocol. RESULTS: Overall, 184 individuals (6%) had AMD. We observed a statistically significant but negative association between AMD and the type of alcohol consumed in a bivariate model (OR 0.86; 95% CI 0.73, 0.99). In the same model, age maintained a consistently strong association with AMD (OR 1.08; 95% CI 1.06-1.11; P <.001). Among the different types of alcohol consumed in NHANES-1 (beer, wine, and liquor), the effect of wine, either alone (OR 0.66; 95% CI 0.55-0.79) or in combination with beer (OR 0.66; 95% CI 0.55-0.79) or liquor (OR 0.74; 95% CI 0.63-0.86), dominated the negative association observed between AMD and alcohol type. Additionally, a statistically significant and negative association between wine and AMD was noted after adjusting for the effect of age, gender, income, history of congestive heart failure, and hypertension (OR 0.81; 93% CI 0.67-0.99). CONCLUSION: Moderate wine consumption is associated with decreased odds of developing AMD. Health promotion and disease prevention activities directed at cardiovascular disease may help reduce the rate of AMD-associated blindness among older people. The nature and pathophysiology of this association warrant further investigation.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalJournal of the American Geriatrics Society
Volume46
Issue number1
StatePublished - Jan 1998
Externally publishedYes

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Nutrition Surveys
Macular Degeneration
Wine
Alcohols
National Eye Institute (U.S.)
Ophthalmology
Blindness
Health Promotion
Case-Control Studies
Cardiovascular Diseases
Heart Failure
Hypertension

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology

Cite this

Moderate wine consumption is associated with decreased odds of developing age-related macular degeneration in NHANES-1. / Obisesan, Thomas O.; Hirsch, Robert; Kosoko-Lasaki, Omofolasade; Carlson, Letitia; Parrott, Marian.

In: Journal of the American Geriatrics Society, Vol. 46, No. 1, 01.1998, p. 1-7.

Research output: Contribution to journalArticle

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abstract = "OBJECTIVE: To determine the association between alcohol intake and the risk of developing age-related macular degeneration (AMD). DESIGN: Case control study. PARTICIPANTS: The sample consisted of 3072 adults 45 to 74 years of age with macular changes indicative of AMD who participated in a nationally representative sample of the first National Health Nutrition and Examination Survey (NHANES-1) between 1971 and 1975: (a) the ophthalmology data set and (b) the medical history questionnaire. MAIN OUTCOME MEASURES: Alcohol intake and the risk of developing AMD were measured. AMD was determined by staff at the National Eye Institute by fundoscopy examination using standardized protocol. RESULTS: Overall, 184 individuals (6{\%}) had AMD. We observed a statistically significant but negative association between AMD and the type of alcohol consumed in a bivariate model (OR 0.86; 95{\%} CI 0.73, 0.99). In the same model, age maintained a consistently strong association with AMD (OR 1.08; 95{\%} CI 1.06-1.11; P <.001). Among the different types of alcohol consumed in NHANES-1 (beer, wine, and liquor), the effect of wine, either alone (OR 0.66; 95{\%} CI 0.55-0.79) or in combination with beer (OR 0.66; 95{\%} CI 0.55-0.79) or liquor (OR 0.74; 95{\%} CI 0.63-0.86), dominated the negative association observed between AMD and alcohol type. Additionally, a statistically significant and negative association between wine and AMD was noted after adjusting for the effect of age, gender, income, history of congestive heart failure, and hypertension (OR 0.81; 93{\%} CI 0.67-0.99). CONCLUSION: Moderate wine consumption is associated with decreased odds of developing AMD. Health promotion and disease prevention activities directed at cardiovascular disease may help reduce the rate of AMD-associated blindness among older people. The nature and pathophysiology of this association warrant further investigation.",
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N2 - OBJECTIVE: To determine the association between alcohol intake and the risk of developing age-related macular degeneration (AMD). DESIGN: Case control study. PARTICIPANTS: The sample consisted of 3072 adults 45 to 74 years of age with macular changes indicative of AMD who participated in a nationally representative sample of the first National Health Nutrition and Examination Survey (NHANES-1) between 1971 and 1975: (a) the ophthalmology data set and (b) the medical history questionnaire. MAIN OUTCOME MEASURES: Alcohol intake and the risk of developing AMD were measured. AMD was determined by staff at the National Eye Institute by fundoscopy examination using standardized protocol. RESULTS: Overall, 184 individuals (6%) had AMD. We observed a statistically significant but negative association between AMD and the type of alcohol consumed in a bivariate model (OR 0.86; 95% CI 0.73, 0.99). In the same model, age maintained a consistently strong association with AMD (OR 1.08; 95% CI 1.06-1.11; P <.001). Among the different types of alcohol consumed in NHANES-1 (beer, wine, and liquor), the effect of wine, either alone (OR 0.66; 95% CI 0.55-0.79) or in combination with beer (OR 0.66; 95% CI 0.55-0.79) or liquor (OR 0.74; 95% CI 0.63-0.86), dominated the negative association observed between AMD and alcohol type. Additionally, a statistically significant and negative association between wine and AMD was noted after adjusting for the effect of age, gender, income, history of congestive heart failure, and hypertension (OR 0.81; 93% CI 0.67-0.99). CONCLUSION: Moderate wine consumption is associated with decreased odds of developing AMD. Health promotion and disease prevention activities directed at cardiovascular disease may help reduce the rate of AMD-associated blindness among older people. The nature and pathophysiology of this association warrant further investigation.

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