Abstract
Detection of extended-spectrum β-lactamases (ESBLs) in AmpC-producing Enterobacteriaceae is problematic. A modification of the double-disk test (MDDT) has been developed for successful detection of ESBLs in gram-negative bacilli producing well-characterized β-lactamases as well as 212 clinical isolates of Enterobacter cloacae, Enterobacter aerogenes, Serratia marcescens, and Citrobacter freundii. MDDT accurately differentiated between ESBL producers and derepressed chromosomal AmpC mutants. MDDT provides a cost-effective alternative approach for clinical microbiology laboratories for routine susceptibility testing with simultaneous detection of ESBLs in Enterobacteriaceae.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3933-3935 |
| Number of pages | 3 |
| Journal | Journal of clinical microbiology |
| Volume | 41 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2003 |
All Science Journal Classification (ASJC) codes
- Microbiology (medical)
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Pitout, J. D. D., Reisbig, M. D., Venter, E. C., Church, D. L., & Hanson, N. D. (2003). Modification of the double-disk test for detection of Enterobacteriaceae producing extended-spectrum and AmpC β-lactamases. Journal of clinical microbiology, 41(8), 3933-3935. https://doi.org/10.1128/JCM.41.8.3933-3935.2003