Molecular Conservation and Novelties in Vertebrate Ear Development

B. Fritzsch, Kirk Beisel

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Citations (Scopus)

Abstract

Evolution shaped the vertebrate ear into a complicated three-dimensional structure and positioned the sensory epithelia so that they can extract specific aspects of mechanical stimuli to govern vestibular and hearing-related responses of the whole organism. This information is conducted from the ear via specific neuronal connections to distinct areas of the hindbrain for proper processing. During development, the otic placode, a simple sheet of epidermal cells, transforms into a complicated system of ducts and recesses. This placode also generates the mechanoelectrical transducers, the hair cells, and sensory neurons of the vestibular and cochlear (spiral) ganglia of the ear. We argue that ear development can be broken down into dynamic processes that use a number of known and unknown genes to govern the formation of the three-dimensional labyrinth in an interactive fashion. Embedded in this process, but in large part independent of it, is an evolutionary conserved process that induces early the development of the neurosensory component of the ear. We present molecular data suggesting that this later process is, in its basic aspects, related to the mechanosensory cell formation across phyla and is extremely conserved at the molecular level. We suggest that sensory neuron development and maintenance are vertebrate or possibly chordate novelties and present the molecular data to support this notion.

Original languageEnglish
Title of host publicationCurrent Topics in Developmental Biology
Pages1-44
Number of pages44
Volume57
DOIs
StatePublished - 2003

Publication series

NameCurrent Topics in Developmental Biology
Volume57
ISSN (Print)00702153

Fingerprint

Ear
Vertebrates
Sensory Receptor Cells
Chordata
Spiral Ganglion
Rhombencephalon
Cochlea
Inner Ear
Transducers
Hearing
Epithelium
Maintenance
Genes

All Science Journal Classification (ASJC) codes

  • Developmental Biology

Cite this

Fritzsch, B., & Beisel, K. (2003). Molecular Conservation and Novelties in Vertebrate Ear Development. In Current Topics in Developmental Biology (Vol. 57, pp. 1-44). (Current Topics in Developmental Biology; Vol. 57). https://doi.org/10.1016/S0070-2153(03)57001-6

Molecular Conservation and Novelties in Vertebrate Ear Development. / Fritzsch, B.; Beisel, Kirk.

Current Topics in Developmental Biology. Vol. 57 2003. p. 1-44 (Current Topics in Developmental Biology; Vol. 57).

Research output: Chapter in Book/Report/Conference proceedingChapter

Fritzsch, B & Beisel, K 2003, Molecular Conservation and Novelties in Vertebrate Ear Development. in Current Topics in Developmental Biology. vol. 57, Current Topics in Developmental Biology, vol. 57, pp. 1-44. https://doi.org/10.1016/S0070-2153(03)57001-6
Fritzsch B, Beisel K. Molecular Conservation and Novelties in Vertebrate Ear Development. In Current Topics in Developmental Biology. Vol. 57. 2003. p. 1-44. (Current Topics in Developmental Biology). https://doi.org/10.1016/S0070-2153(03)57001-6
Fritzsch, B. ; Beisel, Kirk. / Molecular Conservation and Novelties in Vertebrate Ear Development. Current Topics in Developmental Biology. Vol. 57 2003. pp. 1-44 (Current Topics in Developmental Biology).
@inbook{37bd0409da824398b594f143f8255a55,
title = "Molecular Conservation and Novelties in Vertebrate Ear Development",
abstract = "Evolution shaped the vertebrate ear into a complicated three-dimensional structure and positioned the sensory epithelia so that they can extract specific aspects of mechanical stimuli to govern vestibular and hearing-related responses of the whole organism. This information is conducted from the ear via specific neuronal connections to distinct areas of the hindbrain for proper processing. During development, the otic placode, a simple sheet of epidermal cells, transforms into a complicated system of ducts and recesses. This placode also generates the mechanoelectrical transducers, the hair cells, and sensory neurons of the vestibular and cochlear (spiral) ganglia of the ear. We argue that ear development can be broken down into dynamic processes that use a number of known and unknown genes to govern the formation of the three-dimensional labyrinth in an interactive fashion. Embedded in this process, but in large part independent of it, is an evolutionary conserved process that induces early the development of the neurosensory component of the ear. We present molecular data suggesting that this later process is, in its basic aspects, related to the mechanosensory cell formation across phyla and is extremely conserved at the molecular level. We suggest that sensory neuron development and maintenance are vertebrate or possibly chordate novelties and present the molecular data to support this notion.",
author = "B. Fritzsch and Kirk Beisel",
year = "2003",
doi = "10.1016/S0070-2153(03)57001-6",
language = "English",
isbn = "0121531570",
volume = "57",
series = "Current Topics in Developmental Biology",
pages = "1--44",
booktitle = "Current Topics in Developmental Biology",

}

TY - CHAP

T1 - Molecular Conservation and Novelties in Vertebrate Ear Development

AU - Fritzsch, B.

AU - Beisel, Kirk

PY - 2003

Y1 - 2003

N2 - Evolution shaped the vertebrate ear into a complicated three-dimensional structure and positioned the sensory epithelia so that they can extract specific aspects of mechanical stimuli to govern vestibular and hearing-related responses of the whole organism. This information is conducted from the ear via specific neuronal connections to distinct areas of the hindbrain for proper processing. During development, the otic placode, a simple sheet of epidermal cells, transforms into a complicated system of ducts and recesses. This placode also generates the mechanoelectrical transducers, the hair cells, and sensory neurons of the vestibular and cochlear (spiral) ganglia of the ear. We argue that ear development can be broken down into dynamic processes that use a number of known and unknown genes to govern the formation of the three-dimensional labyrinth in an interactive fashion. Embedded in this process, but in large part independent of it, is an evolutionary conserved process that induces early the development of the neurosensory component of the ear. We present molecular data suggesting that this later process is, in its basic aspects, related to the mechanosensory cell formation across phyla and is extremely conserved at the molecular level. We suggest that sensory neuron development and maintenance are vertebrate or possibly chordate novelties and present the molecular data to support this notion.

AB - Evolution shaped the vertebrate ear into a complicated three-dimensional structure and positioned the sensory epithelia so that they can extract specific aspects of mechanical stimuli to govern vestibular and hearing-related responses of the whole organism. This information is conducted from the ear via specific neuronal connections to distinct areas of the hindbrain for proper processing. During development, the otic placode, a simple sheet of epidermal cells, transforms into a complicated system of ducts and recesses. This placode also generates the mechanoelectrical transducers, the hair cells, and sensory neurons of the vestibular and cochlear (spiral) ganglia of the ear. We argue that ear development can be broken down into dynamic processes that use a number of known and unknown genes to govern the formation of the three-dimensional labyrinth in an interactive fashion. Embedded in this process, but in large part independent of it, is an evolutionary conserved process that induces early the development of the neurosensory component of the ear. We present molecular data suggesting that this later process is, in its basic aspects, related to the mechanosensory cell formation across phyla and is extremely conserved at the molecular level. We suggest that sensory neuron development and maintenance are vertebrate or possibly chordate novelties and present the molecular data to support this notion.

UR - http://www.scopus.com/inward/record.url?scp=0642287959&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0642287959&partnerID=8YFLogxK

U2 - 10.1016/S0070-2153(03)57001-6

DO - 10.1016/S0070-2153(03)57001-6

M3 - Chapter

SN - 0121531570

SN - 9780121531577

VL - 57

T3 - Current Topics in Developmental Biology

SP - 1

EP - 44

BT - Current Topics in Developmental Biology

ER -