Abstract
An adolescent male with chronic schizophrenic disorder, paranoid type, was treated with molindone. He developed hepatotoxicity in the early treatment phase as evidenced by flu-like symptoms and laboratory abnormalities of liver functions. These symptoms and his hepatic functions improved on discontinuing molindone. Similar liver function trends were seen on reintroduction and subsequent withdrawal of the drug. Hepatic hypersensitivity has not been reported previously with the use of this drug. It is suggested that clinicians should be aware of this association and should assess hepatic functions in patients who develop a prodromal flu-like syndrome with this drug, especially in the early treatment phase.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 744-746 |
| Number of pages | 3 |
| Journal | Drug Intelligence and Clinical Pharmacy |
| Volume | 19 |
| Issue number | 10 |
| State | Published - Dec 1 1985 |
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All Science Journal Classification (ASJC) codes
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmacology (medical)
Cite this
Molindone and hepatotoxicity. / Bhatia, Subhash; Banta, L. E.; Ehrlich, D. W.
In: Drug Intelligence and Clinical Pharmacy, Vol. 19, No. 10, 01.12.1985, p. 744-746.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molindone and hepatotoxicity
AU - Bhatia, Subhash
AU - Banta, L. E.
AU - Ehrlich, D. W.
PY - 1985/12/1
Y1 - 1985/12/1
N2 - An adolescent male with chronic schizophrenic disorder, paranoid type, was treated with molindone. He developed hepatotoxicity in the early treatment phase as evidenced by flu-like symptoms and laboratory abnormalities of liver functions. These symptoms and his hepatic functions improved on discontinuing molindone. Similar liver function trends were seen on reintroduction and subsequent withdrawal of the drug. Hepatic hypersensitivity has not been reported previously with the use of this drug. It is suggested that clinicians should be aware of this association and should assess hepatic functions in patients who develop a prodromal flu-like syndrome with this drug, especially in the early treatment phase.
AB - An adolescent male with chronic schizophrenic disorder, paranoid type, was treated with molindone. He developed hepatotoxicity in the early treatment phase as evidenced by flu-like symptoms and laboratory abnormalities of liver functions. These symptoms and his hepatic functions improved on discontinuing molindone. Similar liver function trends were seen on reintroduction and subsequent withdrawal of the drug. Hepatic hypersensitivity has not been reported previously with the use of this drug. It is suggested that clinicians should be aware of this association and should assess hepatic functions in patients who develop a prodromal flu-like syndrome with this drug, especially in the early treatment phase.
UR - http://www.scopus.com/inward/record.url?scp=0022366004&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022366004&partnerID=8YFLogxK
M3 - Article
VL - 19
SP - 744
EP - 746
JO - Annals of Pharmacotherapy
JF - Annals of Pharmacotherapy
SN - 1060-0280
IS - 10
ER -