Morphological and morphometric measurements in colorectal mucosa of subjects at increased risk for colonic neoplasia

Astrid Richter, Kan Yang, Frank Richter, Henry T. Lynch, Martin Lipkin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Measurements of intermediate biomarkers have recently increased, attempting to provide useful information about cancer risk. We report morphological findings in rectal mucosal biopsies from patients at low risk and at high risk for colorectal cancer. Rectal biopsies were analyzed from fourteen Seventh-Day Adventist (SDA) subjects at low risk and from twenty-seven members of families with hereditary nonpolyposis colonic cancer (HNPCC) at higher risk. The following measurements were made on rectal crypts: length of crypts, numbers of cells, diameter of the surface, middle and base of the crypts and infiltration of inflammatory cells into the lamina propria. Findings indicated morphological differences in normal-appearing rectal mucosa of individuals in the HNPCC group compared with SDA subjects (P <0.05). They included shorter crypts with fewer epithelial cells and increased cellular infiltration in the mucosa of HNPCC subjects compared with SDA subjects, suggesting minimal inflammation, and an early stage of crypt atrophy in the rectal mucosa of subjects at higher risk for colonic neoplasia.

Original languageEnglish
Pages (from-to)65-68
Number of pages4
JournalCancer Letters
Volume74
Issue number1-2
DOIs
StatePublished - Oct 15 1993

Fingerprint

Mucous Membrane
Colonic Neoplasms
Neoplasms
Biopsy
Atrophy
Colorectal Neoplasms
Cell Count
Biomarkers
Epithelial Cells
Inflammation

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Morphological and morphometric measurements in colorectal mucosa of subjects at increased risk for colonic neoplasia. / Richter, Astrid; Yang, Kan; Richter, Frank; Lynch, Henry T.; Lipkin, Martin.

In: Cancer Letters, Vol. 74, No. 1-2, 15.10.1993, p. 65-68.

Research output: Contribution to journalArticle

Richter, Astrid ; Yang, Kan ; Richter, Frank ; Lynch, Henry T. ; Lipkin, Martin. / Morphological and morphometric measurements in colorectal mucosa of subjects at increased risk for colonic neoplasia. In: Cancer Letters. 1993 ; Vol. 74, No. 1-2. pp. 65-68.
@article{abd4fb728550435bb570ae1fa16be90e,
title = "Morphological and morphometric measurements in colorectal mucosa of subjects at increased risk for colonic neoplasia",
abstract = "Measurements of intermediate biomarkers have recently increased, attempting to provide useful information about cancer risk. We report morphological findings in rectal mucosal biopsies from patients at low risk and at high risk for colorectal cancer. Rectal biopsies were analyzed from fourteen Seventh-Day Adventist (SDA) subjects at low risk and from twenty-seven members of families with hereditary nonpolyposis colonic cancer (HNPCC) at higher risk. The following measurements were made on rectal crypts: length of crypts, numbers of cells, diameter of the surface, middle and base of the crypts and infiltration of inflammatory cells into the lamina propria. Findings indicated morphological differences in normal-appearing rectal mucosa of individuals in the HNPCC group compared with SDA subjects (P <0.05). They included shorter crypts with fewer epithelial cells and increased cellular infiltration in the mucosa of HNPCC subjects compared with SDA subjects, suggesting minimal inflammation, and an early stage of crypt atrophy in the rectal mucosa of subjects at higher risk for colonic neoplasia.",
author = "Astrid Richter and Kan Yang and Frank Richter and Lynch, {Henry T.} and Martin Lipkin",
year = "1993",
month = "10",
day = "15",
doi = "10.1016/0304-3835(93)90045-B",
language = "English",
volume = "74",
pages = "65--68",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - Morphological and morphometric measurements in colorectal mucosa of subjects at increased risk for colonic neoplasia

AU - Richter, Astrid

AU - Yang, Kan

AU - Richter, Frank

AU - Lynch, Henry T.

AU - Lipkin, Martin

PY - 1993/10/15

Y1 - 1993/10/15

N2 - Measurements of intermediate biomarkers have recently increased, attempting to provide useful information about cancer risk. We report morphological findings in rectal mucosal biopsies from patients at low risk and at high risk for colorectal cancer. Rectal biopsies were analyzed from fourteen Seventh-Day Adventist (SDA) subjects at low risk and from twenty-seven members of families with hereditary nonpolyposis colonic cancer (HNPCC) at higher risk. The following measurements were made on rectal crypts: length of crypts, numbers of cells, diameter of the surface, middle and base of the crypts and infiltration of inflammatory cells into the lamina propria. Findings indicated morphological differences in normal-appearing rectal mucosa of individuals in the HNPCC group compared with SDA subjects (P <0.05). They included shorter crypts with fewer epithelial cells and increased cellular infiltration in the mucosa of HNPCC subjects compared with SDA subjects, suggesting minimal inflammation, and an early stage of crypt atrophy in the rectal mucosa of subjects at higher risk for colonic neoplasia.

AB - Measurements of intermediate biomarkers have recently increased, attempting to provide useful information about cancer risk. We report morphological findings in rectal mucosal biopsies from patients at low risk and at high risk for colorectal cancer. Rectal biopsies were analyzed from fourteen Seventh-Day Adventist (SDA) subjects at low risk and from twenty-seven members of families with hereditary nonpolyposis colonic cancer (HNPCC) at higher risk. The following measurements were made on rectal crypts: length of crypts, numbers of cells, diameter of the surface, middle and base of the crypts and infiltration of inflammatory cells into the lamina propria. Findings indicated morphological differences in normal-appearing rectal mucosa of individuals in the HNPCC group compared with SDA subjects (P <0.05). They included shorter crypts with fewer epithelial cells and increased cellular infiltration in the mucosa of HNPCC subjects compared with SDA subjects, suggesting minimal inflammation, and an early stage of crypt atrophy in the rectal mucosa of subjects at higher risk for colonic neoplasia.

UR - http://www.scopus.com/inward/record.url?scp=0027382144&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027382144&partnerID=8YFLogxK

U2 - 10.1016/0304-3835(93)90045-B

DO - 10.1016/0304-3835(93)90045-B

M3 - Article

VL - 74

SP - 65

EP - 68

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 1-2

ER -