TY - JOUR
T1 - Mouse outer hair cells lacking the α9 ACh receptor are motile
AU - He, David Z.Z.
AU - Cheatham, Mary Ann
AU - Pearce, Malini
AU - Vetter, Douglas E.
N1 - Funding Information:
Work supported by grants DC00089 and DC00708 to P. Dallos, DC02764 to L. Madison, DC02871 to S.F. Heinemann, and DC 04696 to Z.Z. He, all from the NIDCD. The Adler Foundation also provided funds to S.F. Heinemann.
PY - 2004/1/31
Y1 - 2004/1/31
N2 - Efferent nerve fibers form chemical synapses at the bases of outer hair cells (OHC), with acetylcholine (ACh) being their principal neurotransmitter. The activation of ACh receptors on OHCs is known to influence cochlear function. These efferent effects exhibit an unusual pharmacology and are generally known to be inhibitory. Recent evidence suggests that an ACh receptor subunit, known as α9, plays a dominant role in mediating the olivocochlear neurotransmission to OHCs. In this investigation, we attempt to determine the possible role(s) of the α9 subunit in regulating OHC function by examining OHC electromotility and compound action potentials (CAP) in mice carrying a null mutation for the α9 gene. Results indicate that cochlear sensitivity, based on CAP thresholds, is similar for homozygous mutant and wild-type mice. Electromotility is also present in OHCs, independent of whether the α9 subunit is present or absent.
AB - Efferent nerve fibers form chemical synapses at the bases of outer hair cells (OHC), with acetylcholine (ACh) being their principal neurotransmitter. The activation of ACh receptors on OHCs is known to influence cochlear function. These efferent effects exhibit an unusual pharmacology and are generally known to be inhibitory. Recent evidence suggests that an ACh receptor subunit, known as α9, plays a dominant role in mediating the olivocochlear neurotransmission to OHCs. In this investigation, we attempt to determine the possible role(s) of the α9 subunit in regulating OHC function by examining OHC electromotility and compound action potentials (CAP) in mice carrying a null mutation for the α9 gene. Results indicate that cochlear sensitivity, based on CAP thresholds, is similar for homozygous mutant and wild-type mice. Electromotility is also present in OHCs, independent of whether the α9 subunit is present or absent.
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U2 - 10.1016/j.devbrainres.2003.10.003
DO - 10.1016/j.devbrainres.2003.10.003
M3 - Article
C2 - 14757515
AN - SCOPUS:0742306816
VL - 148
SP - 19
EP - 25
JO - Developmental Brain Research
JF - Developmental Brain Research
SN - 0165-3806
IS - 1
ER -