Abstract
Efferent nerve fibers form chemical synapses at the bases of outer hair cells (OHC), with acetylcholine (ACh) being their principal neurotransmitter. The activation of ACh receptors on OHCs is known to influence cochlear function. These efferent effects exhibit an unusual pharmacology and are generally known to be inhibitory. Recent evidence suggests that an ACh receptor subunit, known as α9, plays a dominant role in mediating the olivocochlear neurotransmission to OHCs. In this investigation, we attempt to determine the possible role(s) of the α9 subunit in regulating OHC function by examining OHC electromotility and compound action potentials (CAP) in mice carrying a null mutation for the α9 gene. Results indicate that cochlear sensitivity, based on CAP thresholds, is similar for homozygous mutant and wild-type mice. Electromotility is also present in OHCs, independent of whether the α9 subunit is present or absent.
| Original language | English |
|---|---|
| Pages (from-to) | 19-25 |
| Number of pages | 7 |
| Journal | Developmental Brain Research |
| Volume | 148 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 31 2004 |
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All Science Journal Classification (ASJC) codes
- Developmental Biology
- Developmental Neuroscience
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Mouse outer hair cells lacking the α9 ACh receptor are motile. / He, David Z.; Cheatham, Mary Ann; Pearce, Malini; Vetter, Douglas E.
In: Developmental Brain Research, Vol. 148, No. 1, 31.01.2004, p. 19-25.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mouse outer hair cells lacking the α9 ACh receptor are motile
AU - He, David Z.
AU - Cheatham, Mary Ann
AU - Pearce, Malini
AU - Vetter, Douglas E.
PY - 2004/1/31
Y1 - 2004/1/31
N2 - Efferent nerve fibers form chemical synapses at the bases of outer hair cells (OHC), with acetylcholine (ACh) being their principal neurotransmitter. The activation of ACh receptors on OHCs is known to influence cochlear function. These efferent effects exhibit an unusual pharmacology and are generally known to be inhibitory. Recent evidence suggests that an ACh receptor subunit, known as α9, plays a dominant role in mediating the olivocochlear neurotransmission to OHCs. In this investigation, we attempt to determine the possible role(s) of the α9 subunit in regulating OHC function by examining OHC electromotility and compound action potentials (CAP) in mice carrying a null mutation for the α9 gene. Results indicate that cochlear sensitivity, based on CAP thresholds, is similar for homozygous mutant and wild-type mice. Electromotility is also present in OHCs, independent of whether the α9 subunit is present or absent.
AB - Efferent nerve fibers form chemical synapses at the bases of outer hair cells (OHC), with acetylcholine (ACh) being their principal neurotransmitter. The activation of ACh receptors on OHCs is known to influence cochlear function. These efferent effects exhibit an unusual pharmacology and are generally known to be inhibitory. Recent evidence suggests that an ACh receptor subunit, known as α9, plays a dominant role in mediating the olivocochlear neurotransmission to OHCs. In this investigation, we attempt to determine the possible role(s) of the α9 subunit in regulating OHC function by examining OHC electromotility and compound action potentials (CAP) in mice carrying a null mutation for the α9 gene. Results indicate that cochlear sensitivity, based on CAP thresholds, is similar for homozygous mutant and wild-type mice. Electromotility is also present in OHCs, independent of whether the α9 subunit is present or absent.
UR - http://www.scopus.com/inward/record.url?scp=0742306816&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0742306816&partnerID=8YFLogxK
U2 - 10.1016/j.devbrainres.2003.10.003
DO - 10.1016/j.devbrainres.2003.10.003
M3 - Article
C2 - 14757515
AN - SCOPUS:0742306816
VL - 148
SP - 19
EP - 25
JO - Developmental Brain Research
JF - Developmental Brain Research
SN - 0165-3806
IS - 1
ER -