Abstract
This report addresses 1) the predictability of mouse skin models for carcinogenic hazard identification, 2) the association between early changes in the skin and later tumorigenic responses, and 3) the relative sensitivity of three mouse models of skin tumorigenesis; i.e. the genetically-initiated Tg.AC and RasH2 lines and the SENCAR mouse model. All three mouse models responded similarly, with mild inflammation and epidermal hyperplasia, to several weeks of treatment with a topical agent. Based on our previous research experience, we hypothesized that inflammation, irritation, proliferation, and/or hyperplasia in the skin would precede and predict the appearance of tumors in these sensitive mouse skin models. Consistent with our hypothesis, the test agent caused a low but significant tumorigenic response in Tg.AC mice. We propose that inflammation, irritation, and hyperplasia are sensitive predictors of a later tumorigenic response in Tg.AC mice. Further studies are needed, however, to better determine the relative sensitivity of these 3 models to a wider variety of agents.
| Original language | English |
|---|---|
| Pages (from-to) | 853-864 |
| Number of pages | 12 |
| Journal | Toxicologic Pathology |
| Volume | 35 |
| Issue number | 7 |
| DOIs | |
| State | Published - Dec 2007 |
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All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
- Toxicology
- Health, Toxicology and Mutagenesis
Cite this
Mouse skin models for carcinogenic hazard identification : Utilities and challenges. / Lynch, Dave; Svoboda, Jessica; Putta, Sumanth; Hofland, Hans E J; Chern, Wendy H.; Hansen, Laura A.
In: Toxicologic Pathology, Vol. 35, No. 7, 12.2007, p. 853-864.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Mouse skin models for carcinogenic hazard identification
T2 - Utilities and challenges
AU - Lynch, Dave
AU - Svoboda, Jessica
AU - Putta, Sumanth
AU - Hofland, Hans E J
AU - Chern, Wendy H.
AU - Hansen, Laura A.
PY - 2007/12
Y1 - 2007/12
N2 - This report addresses 1) the predictability of mouse skin models for carcinogenic hazard identification, 2) the association between early changes in the skin and later tumorigenic responses, and 3) the relative sensitivity of three mouse models of skin tumorigenesis; i.e. the genetically-initiated Tg.AC and RasH2 lines and the SENCAR mouse model. All three mouse models responded similarly, with mild inflammation and epidermal hyperplasia, to several weeks of treatment with a topical agent. Based on our previous research experience, we hypothesized that inflammation, irritation, proliferation, and/or hyperplasia in the skin would precede and predict the appearance of tumors in these sensitive mouse skin models. Consistent with our hypothesis, the test agent caused a low but significant tumorigenic response in Tg.AC mice. We propose that inflammation, irritation, and hyperplasia are sensitive predictors of a later tumorigenic response in Tg.AC mice. Further studies are needed, however, to better determine the relative sensitivity of these 3 models to a wider variety of agents.
AB - This report addresses 1) the predictability of mouse skin models for carcinogenic hazard identification, 2) the association between early changes in the skin and later tumorigenic responses, and 3) the relative sensitivity of three mouse models of skin tumorigenesis; i.e. the genetically-initiated Tg.AC and RasH2 lines and the SENCAR mouse model. All three mouse models responded similarly, with mild inflammation and epidermal hyperplasia, to several weeks of treatment with a topical agent. Based on our previous research experience, we hypothesized that inflammation, irritation, proliferation, and/or hyperplasia in the skin would precede and predict the appearance of tumors in these sensitive mouse skin models. Consistent with our hypothesis, the test agent caused a low but significant tumorigenic response in Tg.AC mice. We propose that inflammation, irritation, and hyperplasia are sensitive predictors of a later tumorigenic response in Tg.AC mice. Further studies are needed, however, to better determine the relative sensitivity of these 3 models to a wider variety of agents.
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U2 - 10.1080/01926230701748131
DO - 10.1080/01926230701748131
M3 - Review article
VL - 35
SP - 853
EP - 864
JO - Toxicologic Pathology
JF - Toxicologic Pathology
SN - 0192-6233
IS - 7
ER -