MT2-MMP Expression During Early Avian Morphogenesis

Rachel A. Patterson, Ann M. Cavanaugh, Veronica Cantemir, Philip R. Brauer, Mark V. Reedy

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Membrane-type 2 matrix metalloproteinase (MT2-MMP; also called MMP15) is a membrane-bound protease that degrades extracellular matrix and activates proMMPs such as proMMP-2. MMP-2 expression in avian embryos is well documented, but it is not clear how proMMP-2 is activated during avian embryogenesis. Herein, we report that MT2-MMP mRNA is expressed in several tissues including the neural folds and epidermal ectoderm, intermediate mesoderm, pharyngeal arches, limb buds, and dermis. Several, but not all, of these tissues are known to express MMP-2. These observations suggest MT2-MMP may play a role during embryonic development not only through its own proteolytic activity but also by activating proMMP-2.

Original languageEnglish (US)
Pages (from-to)64-70
Number of pages7
JournalAnatomical Record
Volume296
Issue number1
DOIs
StatePublished - Jan 1 2013

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All Science Journal Classification (ASJC) codes

  • Anatomy
  • Biotechnology
  • Histology
  • Ecology, Evolution, Behavior and Systematics

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