MT2-MMP Expression During Early Avian Morphogenesis

Rachel A. Patterson, Ann Cavanaugh, Veronica Cantemir, Philip R. Brauer, Mark Reedy

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Membrane-type 2 matrix metalloproteinase (MT2-MMP; also called MMP15) is a membrane-bound protease that degrades extracellular matrix and activates proMMPs such as proMMP-2. MMP-2 expression in avian embryos is well documented, but it is not clear how proMMP-2 is activated during avian embryogenesis. Herein, we report that MT2-MMP mRNA is expressed in several tissues including the neural folds and epidermal ectoderm, intermediate mesoderm, pharyngeal arches, limb buds, and dermis. Several, but not all, of these tissues are known to express MMP-2. These observations suggest MT2-MMP may play a role during embryonic development not only through its own proteolytic activity but also by activating proMMP-2.

Original languageEnglish
Pages (from-to)64-70
Number of pages7
JournalAnatomical Record
Volume296
Issue number1
DOIs
StatePublished - Jan 2013

Fingerprint

Matrix Metalloproteinase 15
gelatinase A
morphogenesis
Morphogenesis
membrane
matrix
embryonic development
embryogenesis
Matrix Metalloproteinases
bud
arch
Embryonic Development
limb bud
limb
embryo
dermis
fold
Branchial Region
Limb Buds
extracellular matrix

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Histology
  • Ecology, Evolution, Behavior and Systematics
  • Biotechnology

Cite this

MT2-MMP Expression During Early Avian Morphogenesis. / Patterson, Rachel A.; Cavanaugh, Ann; Cantemir, Veronica; Brauer, Philip R.; Reedy, Mark.

In: Anatomical Record, Vol. 296, No. 1, 01.2013, p. 64-70.

Research output: Contribution to journalArticle

Patterson, Rachel A. ; Cavanaugh, Ann ; Cantemir, Veronica ; Brauer, Philip R. ; Reedy, Mark. / MT2-MMP Expression During Early Avian Morphogenesis. In: Anatomical Record. 2013 ; Vol. 296, No. 1. pp. 64-70.
@article{ebf04f92f1824e9dbb7899a239d45dab,
title = "MT2-MMP Expression During Early Avian Morphogenesis",
abstract = "Membrane-type 2 matrix metalloproteinase (MT2-MMP; also called MMP15) is a membrane-bound protease that degrades extracellular matrix and activates proMMPs such as proMMP-2. MMP-2 expression in avian embryos is well documented, but it is not clear how proMMP-2 is activated during avian embryogenesis. Herein, we report that MT2-MMP mRNA is expressed in several tissues including the neural folds and epidermal ectoderm, intermediate mesoderm, pharyngeal arches, limb buds, and dermis. Several, but not all, of these tissues are known to express MMP-2. These observations suggest MT2-MMP may play a role during embryonic development not only through its own proteolytic activity but also by activating proMMP-2.",
author = "Patterson, {Rachel A.} and Ann Cavanaugh and Veronica Cantemir and Brauer, {Philip R.} and Mark Reedy",
year = "2013",
month = "1",
doi = "10.1002/ar.22618",
language = "English",
volume = "296",
pages = "64--70",
journal = "Anatomical Record",
issn = "1932-8486",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - MT2-MMP Expression During Early Avian Morphogenesis

AU - Patterson, Rachel A.

AU - Cavanaugh, Ann

AU - Cantemir, Veronica

AU - Brauer, Philip R.

AU - Reedy, Mark

PY - 2013/1

Y1 - 2013/1

N2 - Membrane-type 2 matrix metalloproteinase (MT2-MMP; also called MMP15) is a membrane-bound protease that degrades extracellular matrix and activates proMMPs such as proMMP-2. MMP-2 expression in avian embryos is well documented, but it is not clear how proMMP-2 is activated during avian embryogenesis. Herein, we report that MT2-MMP mRNA is expressed in several tissues including the neural folds and epidermal ectoderm, intermediate mesoderm, pharyngeal arches, limb buds, and dermis. Several, but not all, of these tissues are known to express MMP-2. These observations suggest MT2-MMP may play a role during embryonic development not only through its own proteolytic activity but also by activating proMMP-2.

AB - Membrane-type 2 matrix metalloproteinase (MT2-MMP; also called MMP15) is a membrane-bound protease that degrades extracellular matrix and activates proMMPs such as proMMP-2. MMP-2 expression in avian embryos is well documented, but it is not clear how proMMP-2 is activated during avian embryogenesis. Herein, we report that MT2-MMP mRNA is expressed in several tissues including the neural folds and epidermal ectoderm, intermediate mesoderm, pharyngeal arches, limb buds, and dermis. Several, but not all, of these tissues are known to express MMP-2. These observations suggest MT2-MMP may play a role during embryonic development not only through its own proteolytic activity but also by activating proMMP-2.

UR - http://www.scopus.com/inward/record.url?scp=84871665218&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871665218&partnerID=8YFLogxK

U2 - 10.1002/ar.22618

DO - 10.1002/ar.22618

M3 - Article

C2 - 23161772

AN - SCOPUS:84871665218

VL - 296

SP - 64

EP - 70

JO - Anatomical Record

JF - Anatomical Record

SN - 1932-8486

IS - 1

ER -