Mucosal excision and suturing for obesity and GERD

András Légner, Kazuto Tsuboi, Rudolf Stadlhuber, Fumiaki Yano, Peter Halvax, Brandon Hunt, Wayne Penka, Charles Filipi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background. Suture and staple-based endoluminal devices for gastroesophageal reflux disease (GERD) and obesity have failed to demonstrate long-term efficacy. Objective. To demonstrate the feasibility of mucosal excision and full-thickness suture apposition of the excision beds to create sufficient scar tissue formation at the gastroesophageal junction for the intraluminal treatment of GERD or obesity. Design. Survival animal experiments. Patients. Seven mongrel dogs. Interventions. Under general endotracheal anesthesia, a Barostat test was performed on 4 dogs. A mucosal excision device was introduced through the esophagus into the proximal stomach. Two to 4 mucosal excisions were performed on all dogs at or just below the gastroesophageal junction and the mucosal pieces were removed. After hemostasis, an intraluminal suturing instrument was introduced and either 2 or 4 sutures were placed through the excision beds to bring them into apposition. These were tied and the suture strands cut. All dogs were survived for 2 months. End-term endoscopies were performed, and a repeat Barostat procedure was performed on the animals undergoing an antireflux procedure. After euthanasia the stomachs were explanted, examined, photographed, and sectioned for histologic examination. Results. All dogs survived without complication. In the 4 GERD dogs, the Barostat studies demonstrated a significant decrease in gastroesophageal junction compliance. In the 3 dogs undergoing the obesity procedure, the gastric outlet apposition to a 6-mm endoscope was satisfactory with full insufflation and the desired scarring was seen on histologic examination. Conclusion. It is possible to create adequate gastroesophageal junction scarring for the treatment of GERD and obesity. A clinical pilot study will be initiated.

Original languageEnglish
Pages (from-to)586-593
Number of pages8
JournalSurgical Innovation
Volume20
Issue number6
DOIs
StatePublished - Dec 2013

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Gastroesophageal Reflux
Obesity
Esophagogastric Junction
Dogs
Sutures
Cicatrix
Stomach
Endotracheal Anesthesia
Equipment and Supplies
Insufflation
Euthanasia
Endoscopes
Hemostasis
General Anesthesia
Esophagus
Endoscopy
Compliance
Survival
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Légner, A., Tsuboi, K., Stadlhuber, R., Yano, F., Halvax, P., Hunt, B., ... Filipi, C. (2013). Mucosal excision and suturing for obesity and GERD. Surgical Innovation, 20(6), 586-593. https://doi.org/10.1177/1553350613475881

Mucosal excision and suturing for obesity and GERD. / Légner, András; Tsuboi, Kazuto; Stadlhuber, Rudolf; Yano, Fumiaki; Halvax, Peter; Hunt, Brandon; Penka, Wayne; Filipi, Charles.

In: Surgical Innovation, Vol. 20, No. 6, 12.2013, p. 586-593.

Research output: Contribution to journalArticle

Légner, A, Tsuboi, K, Stadlhuber, R, Yano, F, Halvax, P, Hunt, B, Penka, W & Filipi, C 2013, 'Mucosal excision and suturing for obesity and GERD', Surgical Innovation, vol. 20, no. 6, pp. 586-593. https://doi.org/10.1177/1553350613475881
Légner A, Tsuboi K, Stadlhuber R, Yano F, Halvax P, Hunt B et al. Mucosal excision and suturing for obesity and GERD. Surgical Innovation. 2013 Dec;20(6):586-593. https://doi.org/10.1177/1553350613475881
Légner, András ; Tsuboi, Kazuto ; Stadlhuber, Rudolf ; Yano, Fumiaki ; Halvax, Peter ; Hunt, Brandon ; Penka, Wayne ; Filipi, Charles. / Mucosal excision and suturing for obesity and GERD. In: Surgical Innovation. 2013 ; Vol. 20, No. 6. pp. 586-593.
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