Muir-Torre syndrome in several members of a family with a variant of the Cancer Family Syndrome

Henry T. Lynch, R. M. Fusaro, L. Roberts, G. J. Voorhees

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Distinguishing cutaneous signs which are associated with hereditary cancer-prone syndromes are known as cancer-associated genodermatoses. Muir-Torre syndrome (M-T) is characterized by the occurrence of sebaceous hyperplasia, adenoma and carcinoma, basal cell carcinoma with sebaceous differentiation, and/or keratoacanthoma in association with visceral cancer (often multiple), and improved survival. Family studies of M-T have been either wholly lacking or too incomplete to elucidate hereditary aetiology. We describe the cutaneous phenotype of M-T in an extended kindred with a possible variant of the Cancer Family Syndrome. We emphasize the need for more thorough documentation of family histories and cancer association in this cancer-associated genodermatosis in order to clarify hereditary syndrome identification, and to improve cancer control through employment of cutaneous signs as a beacon for highly targeted forms of visceral cancer.

Original languageEnglish
Pages (from-to)295-301
Number of pages7
JournalBritish Journal of Dermatology
Volume113
Issue number3
DOIs
StatePublished - 1985

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Muir-Torre Syndrome
Neoplasms
Skin
Hereditary Neoplastic Syndromes
Keratoacanthoma
Basal Cell Carcinoma
Documentation
Adenoma
Hyperplasia
Carcinoma
Phenotype

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Muir-Torre syndrome in several members of a family with a variant of the Cancer Family Syndrome. / Lynch, Henry T.; Fusaro, R. M.; Roberts, L.; Voorhees, G. J.

In: British Journal of Dermatology, Vol. 113, No. 3, 1985, p. 295-301.

Research output: Contribution to journalArticle

Lynch, Henry T. ; Fusaro, R. M. ; Roberts, L. ; Voorhees, G. J. / Muir-Torre syndrome in several members of a family with a variant of the Cancer Family Syndrome. In: British Journal of Dermatology. 1985 ; Vol. 113, No. 3. pp. 295-301.
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