Multicentre study of the learning curve and surgical performance of cytoreductive surgery with intraperitoneal chemotherapy for pseudomyxoma peritonei

S. Kusamura, B. J. Moran, P. H. Sugarbaker, E. A. Levine, D. Elias, D. Baratti, D. L. Morris, A. Sardi, O. Glehen, M. Deraco, F. N. Gilly, P. Barrios, F. Quenet, Brian W. Loggie, A. Gómez Portilla, I. H J T De Hingh, W. P. Ceelen, J. O W Pelz, P. Piso, S. González-Moreno & 4 others K. Van Der Speeten, T. C. Chua, T. D. Yan, W. Liauw

Research output: Contribution to journalArticle

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Abstract

Background: The learning curves for cytoreductive surgery with intraperitoneal chemotherapy for treatment of pseudomyxoma peritonei (PMP) were explored between international centres/surgeons to identify institutional or other factors that might affect performance.

Methods: Data from patients with PMP treated with the combined procedure across 33 international centres between 1993 and 2012 were analysed retrospectively. A risk-adjusted sequential probability ratio test was conducted after defining the target outcome as early oncological failure (disease progression within 2 years of treatment), an acceptable risk for the target outcome (odds ratio) of 2, and type I/II error rates of 5 per cent. The risk prediction model was elaborated and patients were evaluated sequentially for each centre/surgeon. The learning curve was considered to be overcome and proficiency achieved when the odds ratio for early oncological failure became smaller than 2.

Results: Rates of optimal cytoreduction, severe postoperative morbidity and early oncological failure were 84·4, 25·7 and 29·0 per cent respectively. The median annual centre volume was 17 (range 6-66) peritoneal malignancies. Only eight of the 33 centres and six of 47 surgeons achieved proficiency after a median of 100 (range 78-284) and 96 (86-284) procedures respectively. The most important institutional factor affecting surgical performance was centre volume.

Conclusion: The learning curve is extremely long, so centralization and/or networking of centres is necessary to assure quality of services. One centre for every 10-15 million inhabitants would be ideal.

Original languageEnglish
Pages (from-to)1758-1765
Number of pages8
JournalBritish Journal of Surgery
Volume101
Issue number13
DOIs
StatePublished - Dec 1 2014

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Pseudomyxoma Peritonei
Learning Curve
Multicenter Studies
Drug Therapy
Odds Ratio
Disease Progression
Morbidity
Therapeutics
Surgeons
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Medicine(all)

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Multicentre study of the learning curve and surgical performance of cytoreductive surgery with intraperitoneal chemotherapy for pseudomyxoma peritonei. / Kusamura, S.; Moran, B. J.; Sugarbaker, P. H.; Levine, E. A.; Elias, D.; Baratti, D.; Morris, D. L.; Sardi, A.; Glehen, O.; Deraco, M.; Gilly, F. N.; Barrios, P.; Quenet, F.; Loggie, Brian W.; Gómez Portilla, A.; De Hingh, I. H J T; Ceelen, W. P.; Pelz, J. O W; Piso, P.; González-Moreno, S.; Van Der Speeten, K.; Chua, T. C.; Yan, T. D.; Liauw, W.

In: British Journal of Surgery, Vol. 101, No. 13, 01.12.2014, p. 1758-1765.

Research output: Contribution to journalArticle

Kusamura, S, Moran, BJ, Sugarbaker, PH, Levine, EA, Elias, D, Baratti, D, Morris, DL, Sardi, A, Glehen, O, Deraco, M, Gilly, FN, Barrios, P, Quenet, F, Loggie, BW, Gómez Portilla, A, De Hingh, IHJT, Ceelen, WP, Pelz, JOW, Piso, P, González-Moreno, S, Van Der Speeten, K, Chua, TC, Yan, TD & Liauw, W 2014, 'Multicentre study of the learning curve and surgical performance of cytoreductive surgery with intraperitoneal chemotherapy for pseudomyxoma peritonei', British Journal of Surgery, vol. 101, no. 13, pp. 1758-1765. https://doi.org/10.1002/bjs.9674
Kusamura, S. ; Moran, B. J. ; Sugarbaker, P. H. ; Levine, E. A. ; Elias, D. ; Baratti, D. ; Morris, D. L. ; Sardi, A. ; Glehen, O. ; Deraco, M. ; Gilly, F. N. ; Barrios, P. ; Quenet, F. ; Loggie, Brian W. ; Gómez Portilla, A. ; De Hingh, I. H J T ; Ceelen, W. P. ; Pelz, J. O W ; Piso, P. ; González-Moreno, S. ; Van Der Speeten, K. ; Chua, T. C. ; Yan, T. D. ; Liauw, W. / Multicentre study of the learning curve and surgical performance of cytoreductive surgery with intraperitoneal chemotherapy for pseudomyxoma peritonei. In: British Journal of Surgery. 2014 ; Vol. 101, No. 13. pp. 1758-1765.
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abstract = "Background: The learning curves for cytoreductive surgery with intraperitoneal chemotherapy for treatment of pseudomyxoma peritonei (PMP) were explored between international centres/surgeons to identify institutional or other factors that might affect performance.Methods: Data from patients with PMP treated with the combined procedure across 33 international centres between 1993 and 2012 were analysed retrospectively. A risk-adjusted sequential probability ratio test was conducted after defining the target outcome as early oncological failure (disease progression within 2 years of treatment), an acceptable risk for the target outcome (odds ratio) of 2, and type I/II error rates of 5 per cent. The risk prediction model was elaborated and patients were evaluated sequentially for each centre/surgeon. The learning curve was considered to be overcome and proficiency achieved when the odds ratio for early oncological failure became smaller than 2.Results: Rates of optimal cytoreduction, severe postoperative morbidity and early oncological failure were 84·4, 25·7 and 29·0 per cent respectively. The median annual centre volume was 17 (range 6-66) peritoneal malignancies. Only eight of the 33 centres and six of 47 surgeons achieved proficiency after a median of 100 (range 78-284) and 96 (86-284) procedures respectively. The most important institutional factor affecting surgical performance was centre volume.Conclusion: The learning curve is extremely long, so centralization and/or networking of centres is necessary to assure quality of services. One centre for every 10-15 million inhabitants would be ideal.",
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T1 - Multicentre study of the learning curve and surgical performance of cytoreductive surgery with intraperitoneal chemotherapy for pseudomyxoma peritonei

AU - Kusamura, S.

AU - Moran, B. J.

AU - Sugarbaker, P. H.

AU - Levine, E. A.

AU - Elias, D.

AU - Baratti, D.

AU - Morris, D. L.

AU - Sardi, A.

AU - Glehen, O.

AU - Deraco, M.

AU - Gilly, F. N.

AU - Barrios, P.

AU - Quenet, F.

AU - Loggie, Brian W.

AU - Gómez Portilla, A.

AU - De Hingh, I. H J T

AU - Ceelen, W. P.

AU - Pelz, J. O W

AU - Piso, P.

AU - González-Moreno, S.

AU - Van Der Speeten, K.

AU - Chua, T. C.

AU - Yan, T. D.

AU - Liauw, W.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Background: The learning curves for cytoreductive surgery with intraperitoneal chemotherapy for treatment of pseudomyxoma peritonei (PMP) were explored between international centres/surgeons to identify institutional or other factors that might affect performance.Methods: Data from patients with PMP treated with the combined procedure across 33 international centres between 1993 and 2012 were analysed retrospectively. A risk-adjusted sequential probability ratio test was conducted after defining the target outcome as early oncological failure (disease progression within 2 years of treatment), an acceptable risk for the target outcome (odds ratio) of 2, and type I/II error rates of 5 per cent. The risk prediction model was elaborated and patients were evaluated sequentially for each centre/surgeon. The learning curve was considered to be overcome and proficiency achieved when the odds ratio for early oncological failure became smaller than 2.Results: Rates of optimal cytoreduction, severe postoperative morbidity and early oncological failure were 84·4, 25·7 and 29·0 per cent respectively. The median annual centre volume was 17 (range 6-66) peritoneal malignancies. Only eight of the 33 centres and six of 47 surgeons achieved proficiency after a median of 100 (range 78-284) and 96 (86-284) procedures respectively. The most important institutional factor affecting surgical performance was centre volume.Conclusion: The learning curve is extremely long, so centralization and/or networking of centres is necessary to assure quality of services. One centre for every 10-15 million inhabitants would be ideal.

AB - Background: The learning curves for cytoreductive surgery with intraperitoneal chemotherapy for treatment of pseudomyxoma peritonei (PMP) were explored between international centres/surgeons to identify institutional or other factors that might affect performance.Methods: Data from patients with PMP treated with the combined procedure across 33 international centres between 1993 and 2012 were analysed retrospectively. A risk-adjusted sequential probability ratio test was conducted after defining the target outcome as early oncological failure (disease progression within 2 years of treatment), an acceptable risk for the target outcome (odds ratio) of 2, and type I/II error rates of 5 per cent. The risk prediction model was elaborated and patients were evaluated sequentially for each centre/surgeon. The learning curve was considered to be overcome and proficiency achieved when the odds ratio for early oncological failure became smaller than 2.Results: Rates of optimal cytoreduction, severe postoperative morbidity and early oncological failure were 84·4, 25·7 and 29·0 per cent respectively. The median annual centre volume was 17 (range 6-66) peritoneal malignancies. Only eight of the 33 centres and six of 47 surgeons achieved proficiency after a median of 100 (range 78-284) and 96 (86-284) procedures respectively. The most important institutional factor affecting surgical performance was centre volume.Conclusion: The learning curve is extremely long, so centralization and/or networking of centres is necessary to assure quality of services. One centre for every 10-15 million inhabitants would be ideal.

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