Multiple primary cancers and prolonged survival: Familial colonic and endometrial cancers

Henry T. Lynch, Wadi A. Bardawil, Randall E. Harris, Patrick M. Lynch, Hoda A. Guirgis, Jane F. Lynch

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Abstract

We describe features of multiple cancers in a small kindred wherein a cluster of tumors affecting various anatomic sites has been observed among eight direct-line relatives. Three of these individuals have had two or more primary malignancies, and one woman showed a remarkable tolerance to invasive cancer, having had four histologically verified neoplasms (cancers of the ovary, endometrium, and colon, and myelogenous leukemia). The constellation of tumors occurring at an early age among relatives of this kindred supports a genetic etiology.

Original languageEnglish (US)
Pages (from-to)165-168
Number of pages4
JournalDiseases of the Colon & Rectum
Volume21
Issue number3
DOIs
StatePublished - Apr 1 1978

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All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Lynch, H. T., Bardawil, W. A., Harris, R. E., Lynch, P. M., Guirgis, H. A., & Lynch, J. F. (1978). Multiple primary cancers and prolonged survival: Familial colonic and endometrial cancers. Diseases of the Colon & Rectum, 21(3), 165-168. https://doi.org/10.1007/BF02586560