Mutations in two independent pathways are sufficient to create hermaphroditic nematodes

Chris Baldi, Soochin Cho, Ronald E. Ellis

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Although the nematode Caenorhabditis elegans produces self-fertile hermaphrodites, it descended from a male/female species, so hermaphroditism provides a model for the origin of novel traits. In the related species C. remanei, which has only male and female sexes, lowering the activity of tra-2 by RNA interference created XX animals that made spermatids as well as oocytes, but their spermatids could not activate without the addition of male seminal fluid. However, by lowering the expression of both tra-2 and swm-1, a gene that regulates sperm activation in C. elegans, we produced XX animals with active sperm that were self-fertile. Thus, the evolution of hermaphroditism in Caenorhabditis probably required two steps: a mutation in the sex-determination pathway that caused XX spermatogenesis and a mutation that allowed these spermatids to self-activate.

Original languageEnglish
Pages (from-to)1002-1005
Number of pages4
JournalScience
Volume326
Issue number5955
DOIs
StatePublished - Nov 13 2009

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Spermatids
Disorders of Sex Development
Caenorhabditis elegans
Mutation
Spermatozoa
Caenorhabditis
Spermatogenesis
RNA Interference
Oocytes
Genes

All Science Journal Classification (ASJC) codes

  • General

Cite this

Mutations in two independent pathways are sufficient to create hermaphroditic nematodes. / Baldi, Chris; Cho, Soochin; Ellis, Ronald E.

In: Science, Vol. 326, No. 5955, 13.11.2009, p. 1002-1005.

Research output: Contribution to journalArticle

Baldi, Chris ; Cho, Soochin ; Ellis, Ronald E. / Mutations in two independent pathways are sufficient to create hermaphroditic nematodes. In: Science. 2009 ; Vol. 326, No. 5955. pp. 1002-1005.
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