Myocardial uptake and clearance of Tl-201 in healthy subjects

Comparison of adenosine-induced hyperemia and exercise stress

P. A. Siffring, N. C. Gupta, Syed M. Mohiuddin, Dennis J. Esterbrooks, Daniel E. Hilleman, Shih-Chuan Cheng, M. H. Sketch, M. P. Frick

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Pharmacologic stress testing with dipyridamole is useful in patients undergoing thallium-201 myocardial perfusion scintigraphy who cannot adequately exercise. Because dipyridamole increases coronary blood flow by reducing the metabolism of adenosine, the authors compared the uptake and clearance of Tl-201 following exercise stress testing (EST) and resting intravenous infusion of adenosine (AI) in crossover fashion in 20 healthy men. No perfusion defects or areas of redistribution were noted in any of the scans. Mean absolute myocardial Tl-201 uptake was 1.3 times greater with AI than with EST. Mean absolute extracardiac uptake was 2.0 times greater with AI. Mean Tl-201 myocardial clearance was virtually the same in all AI and EST views. During AI, 70% of the subjects experienced e side effects, mean arterial blood pressure decreased by 15%, and heart rate increased by 48%. The effects of adenosine on Tl-201 kinetics in the myocardium are similar to those of EST. Adenosine may be useful as a pharmacologic stress agent in patients undergoing Tl-201 myocardial perfusion scintigraphy.

Original languageEnglish
Pages (from-to)769-774
Number of pages6
JournalRadiology
Volume173
Issue number3
StatePublished - 1989

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Hyperemia
Adenosine
Healthy Volunteers
Exercise
Myocardial Perfusion Imaging
Perfusion Imaging
Dipyridamole
Arterial Pressure
Thallium
Proxy
Intravenous Infusions
Myocardium
Perfusion
Heart Rate

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology

Cite this

Myocardial uptake and clearance of Tl-201 in healthy subjects : Comparison of adenosine-induced hyperemia and exercise stress. / Siffring, P. A.; Gupta, N. C.; Mohiuddin, Syed M.; Esterbrooks, Dennis J.; Hilleman, Daniel E.; Cheng, Shih-Chuan; Sketch, M. H.; Frick, M. P.

In: Radiology, Vol. 173, No. 3, 1989, p. 769-774.

Research output: Contribution to journalArticle

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AU - Cheng, Shih-Chuan

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