Myopathy in Children Receiving Chronic Corticosteroid Therapy for Asthma

Approximately 7 million American children have asthma. First line therapy for the treatment of persistent asthma is inhaled corticosteroid (ICS) medications for long-term control. Oral corticosteroid therapy is also used intermittently as well as long term for individuals with severe persistent asthma. It has been well known for many years that oral corticosteroids can induce an adverse effect of myopathy or muscle weakness. It is less well known that ICS therapy can also induce this same side effect. Myopathy can significantly affect a child—s ability to be physically active and participate in sports. This manuscript reviews studies and case reports of children with asthma experiencing ICS-induced myopathy and discusses alternate treatment options to resolve the condition and return children to an active lifestyle.