Naloxone infusion in acutely narcotized rabbits

J. C. Bradberry, J. Nelson

Research output: Contribution to journalArticlepeer-review

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A study of naloxone infusion and naloxone bolus treatment was conducted in twenty one naive rabbits acutely overdosed with 100 mg/kg of morphine sulfate. The parameters studied were arterial blood gas values, PaO2, PaCO2, pH, HCO3 -, base excess, and O2 saturation) respiratory rates and trends, and pupil size. The results of the arterial blood gas determinations showed naloxone infusion to be as effective as bolus naloxone treatment in four of the six parameters. In addition, the infusion of naloxone was superior to the bolus treatment in two of the six parameters. The respiratory rates showed that the infusion of naloxone produced higher rates than bolus treatment of two time intervals. Also, the respiratory rate trends were much more consistent in the infusion group. No comparison was made of the pupil sizes since they provided no consistent results.

Original languageEnglish (US)
Pages (from-to)355-366
Number of pages12
JournalResearch Communications in Substances of Abuse
Issue number4
StatePublished - 1981
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)


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