Abstract
A study of naloxone infusion and naloxone bolus treatment was conducted in twenty one naive rabbits acutely overdosed with 100 mg/kg of morphine sulfate. The parameters studied were arterial blood gas values, PaO2, PaCO2, pH, HCO3 -, base excess, and O2 saturation) respiratory rates and trends, and pupil size. The results of the arterial blood gas determinations showed naloxone infusion to be as effective as bolus naloxone treatment in four of the six parameters. In addition, the infusion of naloxone was superior to the bolus treatment in two of the six parameters. The respiratory rates showed that the infusion of naloxone produced higher rates than bolus treatment of two time intervals. Also, the respiratory rate trends were much more consistent in the infusion group. No comparison was made of the pupil sizes since they provided no consistent results.
| Original language | English |
|---|---|
| Pages (from-to) | 355-366 |
| Number of pages | 12 |
| Journal | Research Communications in Substances of Abuse |
| Volume | 2 |
| Issue number | 4 |
| State | Published - 1981 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
Cite this
Naloxone infusion in acutely narcotized rabbits. / Bradberry, J. Chris; Nelson, J.
In: Research Communications in Substances of Abuse, Vol. 2, No. 4, 1981, p. 355-366.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Naloxone infusion in acutely narcotized rabbits
AU - Bradberry, J. Chris
AU - Nelson, J.
PY - 1981
Y1 - 1981
N2 - A study of naloxone infusion and naloxone bolus treatment was conducted in twenty one naive rabbits acutely overdosed with 100 mg/kg of morphine sulfate. The parameters studied were arterial blood gas values, PaO2, PaCO2, pH, HCO3 -, base excess, and O2 saturation) respiratory rates and trends, and pupil size. The results of the arterial blood gas determinations showed naloxone infusion to be as effective as bolus naloxone treatment in four of the six parameters. In addition, the infusion of naloxone was superior to the bolus treatment in two of the six parameters. The respiratory rates showed that the infusion of naloxone produced higher rates than bolus treatment of two time intervals. Also, the respiratory rate trends were much more consistent in the infusion group. No comparison was made of the pupil sizes since they provided no consistent results.
AB - A study of naloxone infusion and naloxone bolus treatment was conducted in twenty one naive rabbits acutely overdosed with 100 mg/kg of morphine sulfate. The parameters studied were arterial blood gas values, PaO2, PaCO2, pH, HCO3 -, base excess, and O2 saturation) respiratory rates and trends, and pupil size. The results of the arterial blood gas determinations showed naloxone infusion to be as effective as bolus naloxone treatment in four of the six parameters. In addition, the infusion of naloxone was superior to the bolus treatment in two of the six parameters. The respiratory rates showed that the infusion of naloxone produced higher rates than bolus treatment of two time intervals. Also, the respiratory rate trends were much more consistent in the infusion group. No comparison was made of the pupil sizes since they provided no consistent results.
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M3 - Article
VL - 2
SP - 355
EP - 366
JO - Research Communications in Substances of Abuse
JF - Research Communications in Substances of Abuse
SN - 0193-0818
IS - 4
ER -