Natural history of colorectal cancer in hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II)

Henry T. Lynch, Patrice Watson, Stephen J. Lanspa, Joseph Marcus, Tom Smyrk, Robert Joseph Fitzgibbons, Mary Kriegler, Jane F. Lynch

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Approximately 5 to 6 percent of the total colorectal cancer burden is accounted for by hereditary nonpolyposis colorectal cancer (HNPCC). Because clinical premonitory signs such as those seen in familial polyposis coli (FPC) are lacking, the clinician must recognize clinical findings and family history typical of HNPCC. The authors have described colorectal cancer expression from a survey of ten HNPCC kindreds. Kindred members with colorectal cancer differed significantly (P

Original languageEnglish
Pages (from-to)439-444
Number of pages6
JournalDiseases of the Colon and Rectum
Issue number6
StatePublished - Jun 1988


All Science Journal Classification (ASJC) codes

  • Gastroenterology

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