Natural history of colorectal cancer in hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II)

Henry T. Lynch, Patrice Watson, Stephen J. Lanspa, Joseph Marcus, Tom Smyrk, Robert Joseph Fitzgibbons, Mary Kriegler, Jane F. Lynch

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Approximately 5 to 6 percent of the total colorectal cancer burden is accounted for by hereditary nonpolyposis colorectal cancer (HNPCC). Because clinical premonitory signs such as those seen in familial polyposis coli (FPC) are lacking, the clinician must recognize clinical findings and family history typical of HNPCC. The authors have described colorectal cancer expression from a survey of ten HNPCC kindreds. Kindred members with colorectal cancer differed significantly (P

Original languageEnglish
Pages (from-to)439-444
Number of pages6
JournalDiseases of the Colon and Rectum
Volume31
Issue number6
DOIs
StatePublished - Jun 1988

Fingerprint

Lynch Syndrome II
Hereditary Nonpolyposis Colorectal Neoplasms
Colorectal Neoplasms
Adenomatous Polyposis Coli

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Natural history of colorectal cancer in hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II). / Lynch, Henry T.; Watson, Patrice; Lanspa, Stephen J.; Marcus, Joseph; Smyrk, Tom; Fitzgibbons, Robert Joseph; Kriegler, Mary; Lynch, Jane F.

In: Diseases of the Colon and Rectum, Vol. 31, No. 6, 06.1988, p. 439-444.

Research output: Contribution to journalArticle

@article{1282d0d5fc3a4161b48a1c67b2f3a5cf,
title = "Natural history of colorectal cancer in hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II)",
abstract = "Approximately 5 to 6 percent of the total colorectal cancer burden is accounted for by hereditary nonpolyposis colorectal cancer (HNPCC). Because clinical premonitory signs such as those seen in familial polyposis coli (FPC) are lacking, the clinician must recognize clinical findings and family history typical of HNPCC. The authors have described colorectal cancer expression from a survey of ten HNPCC kindreds. Kindred members with colorectal cancer differed significantly (P",
author = "Lynch, {Henry T.} and Patrice Watson and Lanspa, {Stephen J.} and Joseph Marcus and Tom Smyrk and Fitzgibbons, {Robert Joseph} and Mary Kriegler and Lynch, {Jane F.}",
year = "1988",
month = "6",
doi = "10.1007/BF02552613",
language = "English",
volume = "31",
pages = "439--444",
journal = "Diseases of the Colon and Rectum",
issn = "0012-3706",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Natural history of colorectal cancer in hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II)

AU - Lynch, Henry T.

AU - Watson, Patrice

AU - Lanspa, Stephen J.

AU - Marcus, Joseph

AU - Smyrk, Tom

AU - Fitzgibbons, Robert Joseph

AU - Kriegler, Mary

AU - Lynch, Jane F.

PY - 1988/6

Y1 - 1988/6

N2 - Approximately 5 to 6 percent of the total colorectal cancer burden is accounted for by hereditary nonpolyposis colorectal cancer (HNPCC). Because clinical premonitory signs such as those seen in familial polyposis coli (FPC) are lacking, the clinician must recognize clinical findings and family history typical of HNPCC. The authors have described colorectal cancer expression from a survey of ten HNPCC kindreds. Kindred members with colorectal cancer differed significantly (P

AB - Approximately 5 to 6 percent of the total colorectal cancer burden is accounted for by hereditary nonpolyposis colorectal cancer (HNPCC). Because clinical premonitory signs such as those seen in familial polyposis coli (FPC) are lacking, the clinician must recognize clinical findings and family history typical of HNPCC. The authors have described colorectal cancer expression from a survey of ten HNPCC kindreds. Kindred members with colorectal cancer differed significantly (P

UR - http://www.scopus.com/inward/record.url?scp=0023886544&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023886544&partnerID=8YFLogxK

U2 - 10.1007/BF02552613

DO - 10.1007/BF02552613

M3 - Article

VL - 31

SP - 439

EP - 444

JO - Diseases of the Colon and Rectum

JF - Diseases of the Colon and Rectum

SN - 0012-3706

IS - 6

ER -