Abstract
The natural history of 106 patients from eighteen families manifesting hereditary breast cancer syndromes, and 117 affected patients from twenty families manifesting nonpolyposis hereditary colon cancer were evaluated. Findings were compared with the American College of Surgeons (ACS) long-term audits for breast and colon cancer respectively. The cardinal features of hereditary cancer were observed within the study group, including: (1) a significant younger age of onset (49 years, breast; 46 years, colon); (2) an excess of proximal lesions in the hereditary colon series (49%); and (3) an excess of bilaterality in the hereditary breast cancer patients. The clinical stage at presentation was similar for the hereditary and ACS audit patients. Five-year survival was significantly improved (P <.05) for both hereditary cancer populations as compared to the ACS audits (67% hereditary breast cancer and 52% nonpolyposis hereditary colon cancer). Improved survival in hereditary colon and breast cancer patients may have a bearing on the design of future clinical protocols.
| Original language | English |
|---|---|
| Pages (from-to) | 360-363 |
| Number of pages | 4 |
| Journal | Cancer |
| Volume | 50 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1982 |
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All Science Journal Classification (ASJC) codes
- Cancer Research
- Oncology
Cite this
Natural history of hereditary cancer of the breast and colon. / Albano, W. A.; Recabaren, J. A.; Lynch, Henry T.; Campbell, A. S.; Mailliard, J. A.; Organ, C. H.; Kimberling, W. J.
In: Cancer, Vol. 50, No. 2, 1982, p. 360-363.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Natural history of hereditary cancer of the breast and colon
AU - Albano, W. A.
AU - Recabaren, J. A.
AU - Lynch, Henry T.
AU - Campbell, A. S.
AU - Mailliard, J. A.
AU - Organ, C. H.
AU - Kimberling, W. J.
PY - 1982
Y1 - 1982
N2 - The natural history of 106 patients from eighteen families manifesting hereditary breast cancer syndromes, and 117 affected patients from twenty families manifesting nonpolyposis hereditary colon cancer were evaluated. Findings were compared with the American College of Surgeons (ACS) long-term audits for breast and colon cancer respectively. The cardinal features of hereditary cancer were observed within the study group, including: (1) a significant younger age of onset (49 years, breast; 46 years, colon); (2) an excess of proximal lesions in the hereditary colon series (49%); and (3) an excess of bilaterality in the hereditary breast cancer patients. The clinical stage at presentation was similar for the hereditary and ACS audit patients. Five-year survival was significantly improved (P <.05) for both hereditary cancer populations as compared to the ACS audits (67% hereditary breast cancer and 52% nonpolyposis hereditary colon cancer). Improved survival in hereditary colon and breast cancer patients may have a bearing on the design of future clinical protocols.
AB - The natural history of 106 patients from eighteen families manifesting hereditary breast cancer syndromes, and 117 affected patients from twenty families manifesting nonpolyposis hereditary colon cancer were evaluated. Findings were compared with the American College of Surgeons (ACS) long-term audits for breast and colon cancer respectively. The cardinal features of hereditary cancer were observed within the study group, including: (1) a significant younger age of onset (49 years, breast; 46 years, colon); (2) an excess of proximal lesions in the hereditary colon series (49%); and (3) an excess of bilaterality in the hereditary breast cancer patients. The clinical stage at presentation was similar for the hereditary and ACS audit patients. Five-year survival was significantly improved (P <.05) for both hereditary cancer populations as compared to the ACS audits (67% hereditary breast cancer and 52% nonpolyposis hereditary colon cancer). Improved survival in hereditary colon and breast cancer patients may have a bearing on the design of future clinical protocols.
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U2 - 10.1002/1097-0142(19820715)50:2<360::AID-CNCR2820500233>3.0.CO;2-4
DO - 10.1002/1097-0142(19820715)50:2<360::AID-CNCR2820500233>3.0.CO;2-4
M3 - Article
C2 - 7083143
AN - SCOPUS:0019943389
VL - 50
SP - 360
EP - 363
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 2
ER -