Natural history of hereditary cancer of the breast and colon

W. A. Albano, J. A. Recabaren, Henry T. Lynch, A. S. Campbell, J. A. Mailliard, C. H. Organ, W. J. Kimberling

Research output: Contribution to journal › Article

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Abstract

The natural history of 106 patients from eighteen families manifesting hereditary breast cancer syndromes, and 117 affected patients from twenty families manifesting nonpolyposis hereditary colon cancer were evaluated. Findings were compared with the American College of Surgeons (ACS) long-term audits for breast and colon cancer respectively. The cardinal features of hereditary cancer were observed within the study group, including: (1) a significant younger age of onset (49 years, breast; 46 years, colon); (2) an excess of proximal lesions in the hereditary colon series (49%); and (3) an excess of bilaterality in the hereditary breast cancer patients. The clinical stage at presentation was similar for the hereditary and ACS audit patients. Five-year survival was significantly improved (P <.05) for both hereditary cancer populations as compared to the ACS audits (67% hereditary breast cancer and 52% nonpolyposis hereditary colon cancer). Improved survival in hereditary colon and breast cancer patients may have a bearing on the design of future clinical protocols.

Original languageEnglish
Pages (from-to)360-363
Number of pages4
JournalCancer
Volume50
Issue number2
DOIs
StatePublished - 1982

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Colonic Neoplasms
Breast Neoplasms
Hereditary Nonpolyposis Colorectal Neoplasms
Colon
Hereditary Neoplastic Syndromes
Survival
Clinical Protocols
Natural History
Age of Onset
Neoplasms
Breast
Population
Surgeons

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Albano, W. A., Recabaren, J. A., Lynch, H. T., Campbell, A. S., Mailliard, J. A., Organ, C. H., & Kimberling, W. J. (1982). Natural history of hereditary cancer of the breast and colon. Cancer, 50(2), 360-363. https://doi.org/10.1002/1097-0142(19820715)50:2<360::AID-CNCR2820500233>3.0.CO;2-4

Natural history of hereditary cancer of the breast and colon. / Albano, W. A.; Recabaren, J. A.; Lynch, Henry T.; Campbell, A. S.; Mailliard, J. A.; Organ, C. H.; Kimberling, W. J.

In: Cancer, Vol. 50, No. 2, 1982, p. 360-363.

Research output: Contribution to journal › Article

Albano, WA, Recabaren, JA, Lynch, HT, Campbell, AS, Mailliard, JA, Organ, CH & Kimberling, WJ 1982, 'Natural history of hereditary cancer of the breast and colon', Cancer, vol. 50, no. 2, pp. 360-363. https://doi.org/10.1002/1097-0142(19820715)50:2<360::AID-CNCR2820500233>3.0.CO;2-4
Albano WA, Recabaren JA, Lynch HT, Campbell AS, Mailliard JA, Organ CH et al. Natural history of hereditary cancer of the breast and colon. Cancer. 1982;50(2):360-363. https://doi.org/10.1002/1097-0142(19820715)50:2<360::AID-CNCR2820500233>3.0.CO;2-4
Albano, W. A. ; Recabaren, J. A. ; Lynch, Henry T. ; Campbell, A. S. ; Mailliard, J. A. ; Organ, C. H. ; Kimberling, W. J. / Natural history of hereditary cancer of the breast and colon. In: Cancer. 1982 ; Vol. 50, No. 2. pp. 360-363.
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