Natural Polyphenols in Cancer Chemoresistance

Saad A. Hussain, Amal A. Sulaiman, Curt Balch, Harsh Chauhan, Qasim M. Alhadidi, Amit K. Tiwari

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

ABSTRACT: Resistance to chemotherapy remains a major impediment to the management of most types of cancer. Both intrinsic and acquired drug resistance are mediated by several cellular and molecular mechanisms, including alternative growth-signaling pathways unaffected by specific therapies, alterations in the tumor microenvironment (e.g., hypoxia and angiogenesis), and active transport of drugs out of the cell. Epidemiological studies have validated an inverse correlation between the consumption of dietary polyphenols and the risk of cancer, which has been attributed to polyphenol antioxidant capacity and their potential to inhibit activation of procarcinogens, cancer cell proliferation, metastasis, and angiogenesis, and inhibition or downregulation of active drug efflux transporters. Moreover, polyphenols can induce apoptosis in cancer cells and modulate immune responses and inflammatory cascades. Augmentation of the efficacy of chemotherapy and prevention of multidrug resistance are other important effects of dietary polyphenols that deserve further research, especially after the discovery of tight “crosstalk” between aberrant growth signaling and metabolic dysfunction in cancer cells. In this review, we cover what is currently known about the role of natural polyphenolic compounds in overcoming cancer drug resistance mediated by diverse primary and secondary resistance mechanisms.

Original languageEnglish
Pages (from-to)879-891
Number of pages13
JournalNutrition and Cancer
Volume68
Issue number6
DOIs
StatePublished - Aug 17 2016

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Polyphenols
Neoplasms
Drug Resistance
Drug Therapy
Tumor Microenvironment
Active Biological Transport
Multiple Drug Resistance
Growth
Pharmaceutical Preparations
Epidemiologic Studies
Down-Regulation
Antioxidants
Cell Proliferation
Apoptosis
Neoplasm Metastasis
Research

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Oncology
  • Cancer Research

Cite this

Hussain, S. A., Sulaiman, A. A., Balch, C., Chauhan, H., Alhadidi, Q. M., & Tiwari, A. K. (2016). Natural Polyphenols in Cancer Chemoresistance. Nutrition and Cancer, 68(6), 879-891. https://doi.org/10.1080/01635581.2016.1192201

Natural Polyphenols in Cancer Chemoresistance. / Hussain, Saad A.; Sulaiman, Amal A.; Balch, Curt; Chauhan, Harsh; Alhadidi, Qasim M.; Tiwari, Amit K.

In: Nutrition and Cancer, Vol. 68, No. 6, 17.08.2016, p. 879-891.

Research output: Contribution to journalReview article

Hussain, SA, Sulaiman, AA, Balch, C, Chauhan, H, Alhadidi, QM & Tiwari, AK 2016, 'Natural Polyphenols in Cancer Chemoresistance', Nutrition and Cancer, vol. 68, no. 6, pp. 879-891. https://doi.org/10.1080/01635581.2016.1192201
Hussain SA, Sulaiman AA, Balch C, Chauhan H, Alhadidi QM, Tiwari AK. Natural Polyphenols in Cancer Chemoresistance. Nutrition and Cancer. 2016 Aug 17;68(6):879-891. https://doi.org/10.1080/01635581.2016.1192201
Hussain, Saad A. ; Sulaiman, Amal A. ; Balch, Curt ; Chauhan, Harsh ; Alhadidi, Qasim M. ; Tiwari, Amit K. / Natural Polyphenols in Cancer Chemoresistance. In: Nutrition and Cancer. 2016 ; Vol. 68, No. 6. pp. 879-891.
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