Nature of the motor element in electrokinetic shape changes of cochlear outer hair cells

Peter Dallos, Burt N. Evans, Richard J. Hallworth

Research output: Contribution to journalArticle

165 Citations (Scopus)

Abstract

IT is the prevailing notion that cochlear outer hair cells function as mechanical effectors as well as sensory receptors1-3. Electrically induced changes in the shape of mammalian outer hair cells4,5, studied in vitro, are commonly assumed to represent an aspect of their effector process that may occur in vivo. The nature of the motile process is obscure, even though none of the established cellular motors can be involved6. Although it is known that the motile response is under voltage control7, it is uncertain whether the stimulus is a drop in the voltage along the long axis of the cell or variation in the transmembrane potential. We have now performed experiments with cells partitioned in differing degrees between two chambers. Applied voltage stimulates the cell membrane segments in opposite polarity to an amount dependent on the partitioning. The findings show, in accordance with previous suggestions6-8, that the driving stimulus is a local transmembrane voltage drop and that the cellular motor consists of many independent elements, distributed along the cell membrane and its associated cortical structures. We further show that the primary action of the motor elements is along the longitudinal dimension of the cell without necessarily involving changes in intracellular hydrostatic pressure. This establishes the outer hair cell motor as unique among mechanisms that control cell shape9.

Original languageEnglish
Pages (from-to)155-157
Number of pages3
JournalNature
Volume350
Issue number6314
StatePublished - 1991
Externally publishedYes

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Outer Auditory Hair Cells
Cell Membrane
Hydrostatic Pressure
Membrane Potentials

All Science Journal Classification (ASJC) codes

  • General

Cite this

Dallos, P., Evans, B. N., & Hallworth, R. J. (1991). Nature of the motor element in electrokinetic shape changes of cochlear outer hair cells. Nature, 350(6314), 155-157.

Nature of the motor element in electrokinetic shape changes of cochlear outer hair cells. / Dallos, Peter; Evans, Burt N.; Hallworth, Richard J.

In: Nature, Vol. 350, No. 6314, 1991, p. 155-157.

Research output: Contribution to journalArticle

Dallos, P, Evans, BN & Hallworth, RJ 1991, 'Nature of the motor element in electrokinetic shape changes of cochlear outer hair cells', Nature, vol. 350, no. 6314, pp. 155-157.
Dallos, Peter ; Evans, Burt N. ; Hallworth, Richard J. / Nature of the motor element in electrokinetic shape changes of cochlear outer hair cells. In: Nature. 1991 ; Vol. 350, No. 6314. pp. 155-157.
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