Neurofibrillary tangles and neuropil threads as a cause of dementia in Parkinson's disease

H. Braak, E. Braak, D. Yilmazer, R. A.I. De Vos, E. N.H. Jansen, J. Bohl

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common age-related degenerative disorders of the human brain. Both diseases involve multiple neuronal systems and are the consequences of cytoskeletal abnormalities. In AD susceptible neurons produce neurofibrillary changes, while in Parkinson's disease, they develop Lewy bodies. In AD six developmental stages can be distinguished on account of the predictable manner in which the neurofibrillary changes spread across the cerebral cortex. During the course of PD numerous limbic determined parts of the brain undergo specific lesions regulating endocrine and autonomic functions. In general, the extranigral destructions are in themselves not sufficient to produce overt intellectual deterioration. Fully developed Parkinson's disease with concurring incipient Alzheimer's disease is likely to cause impaired cognition.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalJournal of Neural Transmission, Supplement
Issue number51
StatePublished - Dec 1 1997

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry


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