Neuropeptide γ-(1-9)-peptide: A major product of the posttranslational processing of γ-preprotachykinin in rat tissues

Y. Wang, Charles Bockman, Sándor Lovas, Peter W. Abel, R. F. Murphy, J. M. Conlon

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

γ-Preprotachykinin mRNA is the most abundant tachykinin mRNA in rat tissues, but the pathway of posttranslational processing of its translation product is unknown. An antiserum was raised against the synthetic peptide Asp-Ala-Gly-His-Gly-Gln-Ile-Ser-His [neuropeptide γ-(1-9)-peptide, equivalent to γ-preprotachykinin-(72-80)-peptide], that showed 70-Arg71 in γ- preprotachykinin is a major site of posttranslational processing, but the resulting product, neuropeptide γ-(1-9)-peptide, is neither an agonist nor an antagonist at the neurokinin-2 (NK-2) receptor.

Original languageEnglish
Pages (from-to)1231-1235
Number of pages5
JournalJournal of Neurochemistry
Volume61
Issue number4
StatePublished - 1993

Fingerprint

Neuropeptides
Rats
Tissue
Peptides
Processing
Neurokinin-2 Receptors
Tachykinins
Messenger RNA
Immune Sera
peptide A
preprotachykinin

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Neuropeptide γ-(1-9)-peptide : A major product of the posttranslational processing of γ-preprotachykinin in rat tissues. / Wang, Y.; Bockman, Charles; Lovas, Sándor; Abel, Peter W.; Murphy, R. F.; Conlon, J. M.

In: Journal of Neurochemistry, Vol. 61, No. 4, 1993, p. 1231-1235.

Research output: Contribution to journalArticle

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