Neuropeptide γ‐(l‐9)‐Peptide: A Major Product of the Posttranslational Processing of γ‐Preprotachykinin in Rat Tissues

Yunxia Wang, Charles S. Bockman, Sandor Lovas, Peter W. Abel, Richard F. Murphy, J. Michael Conlon

Research output: Contribution to journalArticle

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γ-Preprotachykinin mRNA is the most abundant tachykinin mRNA in rat tissues, but the pathway of posttranslational processing of its translation product is unknown. An antiserum was raised against the synthetic peptide Asp-Ala-Gly-His-Gly-Gln-Ile-Ser-His [neuropeptide γ-(1-9)-peptide, equivalent to γ-preprotachykinin-(72-80)-peptide], that showed 70-Arg71 in γ- preprotachykinin is a major site of posttranslational processing, but the resulting product, neuropeptide γ-(1-9)-peptide, is neither an agonist nor an antagonist at the neurokinin-2 (NK-2) receptor.

Original languageEnglish (US)
Pages (from-to)1231-1235
Number of pages5
JournalJournal of Neurochemistry
Issue number4
StatePublished - Oct 1993


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

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