Neuropeptide Y levels during ischemia and reperfusion in the canine infrarenal aortic revascularization model

John D. Edwards, Peter S. Dovgan, Jane M. Rowley, Patricia E. Thorpe, Thomas E. Adrian, Devendra K. Agrawal

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations

    Abstract

    Neuropeptide Y (NPY) is a potent vasoconstrictive polypeptide colocalized with norepinephrine in sympathetic neurons. The effects of ischemia and reperfusion on plasma NPY levels were studied and compared in the mongrel dog after infrarenal aortic cross-clamping. We found a two-to threefold increase in NPY levels during ischemia (initial 10.0 ± 1.8 pmol/L vs. maximum 24.7 ± 2.31 pmole/L, p<0.001). The increase in NPY remained following reperfusion (initial 10.0 ± 0.8 pmole/L vs. maximum 23.9 ± 2.31 pmole/L, p<0.001). These data reveal that NPY is released during ischemia and reperfusion and may be involved in mediating remote vascular events associated with infrarenal aortic cross-clamping.

    Original languageEnglish
    Pages (from-to)350-355
    Number of pages6
    JournalAnnals of Vascular Surgery
    Volume8
    Issue number4
    DOIs
    StatePublished - Jul 1994

    All Science Journal Classification (ASJC) codes

    • Cardiology and Cardiovascular Medicine

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