Neuropeptide Y levels during ischemia and reperfusion in the canine infrarenal aortic revascularization model

John D. Edwards; Peter S. Dovgan; Jane M. Rowley; Patricia E. Thorpe; Thomas E. Adrian; Devendra K. Agrawal

doi:10.1007/BF02132996

Neuropeptide Y levels during ischemia and reperfusion in the canine infrarenal aortic revascularization model

John D. Edwards, Peter S. Dovgan, Jane M. Rowley, Patricia E. Thorpe, Thomas E. Adrian, Devendra K. Agrawal

Department of Clinical and Translational Science

Research output: Contribution to journal › Article

1 Scopus citations

Abstract

Neuropeptide Y (NPY) is a potent vasoconstrictive polypeptide colocalized with norepinephrine in sympathetic neurons. The effects of ischemia and reperfusion on plasma NPY levels were studied and compared in the mongrel dog after infrarenal aortic cross-clamping. We found a two-to threefold increase in NPY levels during ischemia (initial 10.0 ± 1.8 pmol/L vs. maximum 24.7 ± 2.31 pmole/L, p<0.001). The increase in NPY remained following reperfusion (initial 10.0 ± 0.8 pmole/L vs. maximum 23.9 ± 2.31 pmole/L, p<0.001). These data reveal that NPY is released during ischemia and reperfusion and may be involved in mediating remote vascular events associated with infrarenal aortic cross-clamping.

Original language	English
Pages (from-to)	350-355
Number of pages	6
Journal	Annals of Vascular Surgery
Volume	8
Issue number	4
DOIs	https://doi.org/10.1007/BF02132996
State	Published - Jul 1994

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All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

Cite this

Edwards, J. D., Dovgan, P. S., Rowley, J. M., Thorpe, P. E., Adrian, T. E., & Agrawal, D. K. (1994). Neuropeptide Y levels during ischemia and reperfusion in the canine infrarenal aortic revascularization model. Annals of Vascular Surgery, 8(4), 350-355. https://doi.org/10.1007/BF02132996

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abstract = "Neuropeptide Y (NPY) is a potent vasoconstrictive polypeptide colocalized with norepinephrine in sympathetic neurons. The effects of ischemia and reperfusion on plasma NPY levels were studied and compared in the mongrel dog after infrarenal aortic cross-clamping. We found a two-to threefold increase in NPY levels during ischemia (initial 10.0 ± 1.8 pmol/L vs. maximum 24.7 ± 2.31 pmole/L, p<0.001). The increase in NPY remained following reperfusion (initial 10.0 ± 0.8 pmole/L vs. maximum 23.9 ± 2.31 pmole/L, p<0.001). These data reveal that NPY is released during ischemia and reperfusion and may be involved in mediating remote vascular events associated with infrarenal aortic cross-clamping.",

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AU - Dovgan, Peter S.

AU - Rowley, Jane M.

AU - Thorpe, Patricia E.

AU - Adrian, Thomas E.

AU - Agrawal, Devendra K.

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AB - Neuropeptide Y (NPY) is a potent vasoconstrictive polypeptide colocalized with norepinephrine in sympathetic neurons. The effects of ischemia and reperfusion on plasma NPY levels were studied and compared in the mongrel dog after infrarenal aortic cross-clamping. We found a two-to threefold increase in NPY levels during ischemia (initial 10.0 ± 1.8 pmol/L vs. maximum 24.7 ± 2.31 pmole/L, p<0.001). The increase in NPY remained following reperfusion (initial 10.0 ± 0.8 pmole/L vs. maximum 23.9 ± 2.31 pmole/L, p<0.001). These data reveal that NPY is released during ischemia and reperfusion and may be involved in mediating remote vascular events associated with infrarenal aortic cross-clamping.

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10.1007/BF02132996