Abstract
Neuropeptide Y (NPY) is a potent vasoconstrictive polypeptide colocalized with norepinephrine in sympathetic neurons. The effects of ischemia and reperfusion on plasma NPY levels were studied and compared in the mongrel dog after infrarenal aortic cross-clamping. We found a two-to threefold increase in NPY levels during ischemia (initial 10.0 ± 1.8 pmol/L vs. maximum 24.7 ± 2.31 pmole/L, p<0.001). The increase in NPY remained following reperfusion (initial 10.0 ± 0.8 pmole/L vs. maximum 23.9 ± 2.31 pmole/L, p<0.001). These data reveal that NPY is released during ischemia and reperfusion and may be involved in mediating remote vascular events associated with infrarenal aortic cross-clamping.
| Original language | English |
|---|---|
| Pages (from-to) | 350-355 |
| Number of pages | 6 |
| Journal | Annals of Vascular Surgery |
| Volume | 8 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 1994 |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
Cite this
Neuropeptide Y levels during ischemia and reperfusion in the canine infrarenal aortic revascularization model. / Edwards, John D.; Dovgan, Peter S.; Rowley, Jane M.; Thorpe, Patricia E.; Adrian, Thomas E.; Agrawal, Devendra K.
In: Annals of Vascular Surgery, Vol. 8, No. 4, 07.1994, p. 350-355.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuropeptide Y levels during ischemia and reperfusion in the canine infrarenal aortic revascularization model
AU - Edwards, John D.
AU - Dovgan, Peter S.
AU - Rowley, Jane M.
AU - Thorpe, Patricia E.
AU - Adrian, Thomas E.
AU - Agrawal, Devendra K.
PY - 1994/7
Y1 - 1994/7
N2 - Neuropeptide Y (NPY) is a potent vasoconstrictive polypeptide colocalized with norepinephrine in sympathetic neurons. The effects of ischemia and reperfusion on plasma NPY levels were studied and compared in the mongrel dog after infrarenal aortic cross-clamping. We found a two-to threefold increase in NPY levels during ischemia (initial 10.0 ± 1.8 pmol/L vs. maximum 24.7 ± 2.31 pmole/L, p<0.001). The increase in NPY remained following reperfusion (initial 10.0 ± 0.8 pmole/L vs. maximum 23.9 ± 2.31 pmole/L, p<0.001). These data reveal that NPY is released during ischemia and reperfusion and may be involved in mediating remote vascular events associated with infrarenal aortic cross-clamping.
AB - Neuropeptide Y (NPY) is a potent vasoconstrictive polypeptide colocalized with norepinephrine in sympathetic neurons. The effects of ischemia and reperfusion on plasma NPY levels were studied and compared in the mongrel dog after infrarenal aortic cross-clamping. We found a two-to threefold increase in NPY levels during ischemia (initial 10.0 ± 1.8 pmol/L vs. maximum 24.7 ± 2.31 pmole/L, p<0.001). The increase in NPY remained following reperfusion (initial 10.0 ± 0.8 pmole/L vs. maximum 23.9 ± 2.31 pmole/L, p<0.001). These data reveal that NPY is released during ischemia and reperfusion and may be involved in mediating remote vascular events associated with infrarenal aortic cross-clamping.
UR - http://www.scopus.com/inward/record.url?scp=0028122095&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028122095&partnerID=8YFLogxK
U2 - 10.1007/BF02132996
DO - 10.1007/BF02132996
M3 - Article
VL - 8
SP - 350
EP - 355
JO - Annals of Vascular Surgery
JF - Annals of Vascular Surgery
SN - 0890-5096
IS - 4
ER -