Neurotrophins and hearing dysfunction: Comparing models to stop nerve fiber loss

Theodore F. Wissink, Chad Moes, Kirk Beisel, Bernd Fritzsch

Research output: Contribution to journalReview article

3 Scopus citations


Two neurotrophins and their high affinity tyrosine kinase receptors mediate neuronal survival and fiber guidance in the developing ear. Neurotrophins are also essential for adult sensory survival. New models based on other tyrosine kinase receptor treatments may help maintain inner ear innervation beyond the apparently inevitable loss of hair cells with age, one major source of neurotrophins in the adult ear, and may improve prospects to treat hearing loss.

Original languageEnglish
Pages (from-to)391-396
Number of pages6
JournalDrug Discovery Today: Disease Models
Issue number4
Publication statusPublished - 2007


All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

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