New phenotypic aspects in a family with lynch syndrome II

G. Cristofaro, H. T. Lynch, M. L. Caruso, A. Attolini, G. Dimatteo, P. Giorgio, S. Senatore, A. Argentieri, E. Sbano, G. Guanti, R. Fusaro, I. Giorgio

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62 Scopus citations

Abstract

Increasing attention has been given to hereditary nonpolyposis colorectal cancer (HNPCC). This report provides medical genetic/pathologic findings on an HNPCC kindred from southern Italy that shows criteria consistent with Lynch syndrome II. An international collaborative effort led to extension of this kindred with disclosure of a potentially new spectrum of phenotypic findings: an excess of gastric carcinoma; complete intestinal metaplasia and chronic atrophic gastritis restricted to the antrum; an apparent excess of colonic mucosal macrophagia, which by special appeared to be positive for mucin, with a constant content of both sialo and sulfomucin, a lack of iron, and an inconstant positivity for lysosyme obtained by immunoperoxidase technique; and findings of crypt atrophy of the colonic mucosa. During the relatively short period of investigation of this family, an intensive educational and surveillance program has been mounted in the interest of improving cancer control through direct application of knowledge of natural history and the risk for evidence through pedigree assessment.

Original languageEnglish (US)
Pages (from-to)51-58
Number of pages8
JournalCancer
Volume60
Issue number1
DOIs
StatePublished - Jul 1 1987
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Cristofaro, G., Lynch, H. T., Caruso, M. L., Attolini, A., Dimatteo, G., Giorgio, P., Senatore, S., Argentieri, A., Sbano, E., Guanti, G., Fusaro, R., & Giorgio, I. (1987). New phenotypic aspects in a family with lynch syndrome II. Cancer, 60(1), 51-58. https://doi.org/10.1002/1097-0142(19870701)60:1<51::AID-CNCR2820600110>3.0.CO;2-V