No evidence of mineralization abnormalities in iliac bone of premenopausal women with type 2 diabetes mellitus

Barbara M. Misof, Stéphane Blouin, Vicente F.C. Andrade, Paul Roschger, Victoria Z.C. Borba, Markus A. Hartmann, Jochen Zwerina, Robert R. Recker, Carolina A. Moreira

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Patients with type-2 diabetes mellitus (T2DM) have increased risk for bone fractures which points towards impaired bone quality. Methods: We measured bone mineralization density distribution (BMDD) and osteocyte lacunae section (OLS) characteristics based on quantitative backscattered electron images of transiliac biopsy samples from n=26 premenopausal women with T2DM. Outcomes were compared to those from reference cohorts as well as between T2DM subgroups defined by clinical characteristics. Results: Comparison to references did not reveal any differences in BMDD (all p>0.05) but a lowered OLS-density in cancellous bone in T2DM (-14.9%, p<0.001). Neither BMDD nor OLS-characteristics differed in T2DM subgroups defined by HbA1c (<7% versus >7%). The average degree of bone mineralization (CaMean) was higher (0.44 wt%Ca in T2DM, 0.30 wt%Ca in reference) and consistently the calcium concentration between the tetracycline double labels (CaYoung) was higher (0.76 wt%Ca, all p<0.001) in cancellous versus cortical bone. Conclusions: Our findings suggest that bone matrix mineralization was neither affected by the presence nor by the glycemic control of T2DM in our study cohort. The intra-individual differences between cancellous and cortical bone mineralization gave evidence for differences in the time course of the early mineralization process in these compartments in general.

Original languageEnglish (US)
Pages (from-to)305-315
Number of pages11
JournalJournal of Musculoskeletal Neuronal Interactions
Volume22
Issue number3
StatePublished - Sep 2022

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Orthopedics and Sports Medicine

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