Norepinephrine produces tension through electromechanical coupling in rabbit ear artery

Angelo Trapani, Norio Matsuki, Peter W. Abel, Kent Hermsmeyer

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Membrane potential (Em) and contractile responses to norepinephrine (NE) were measured to determine whether electromechanical coupling is important in the rabbit ear artery. NE contraction and depolarization of the vascular muscle cells were both dose dependent, with a positive correlation between depolarization and tension generated by the vessel. These studies suggest that NE regulates vascular muscle contraction through an Em signal in the rabbit ear artery.

Original languageEnglish
Pages (from-to)87-91
Number of pages5
JournalEuropean Journal of Pharmacology
Volume72
Issue number1
DOIs
StatePublished - Jun 10 1981
Externally publishedYes

Fingerprint

Ear
Norepinephrine
Arteries
Rabbits
Blood Vessels
Muscle Contraction
Membrane Potentials
Muscle Cells

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Norepinephrine produces tension through electromechanical coupling in rabbit ear artery. / Trapani, Angelo; Matsuki, Norio; Abel, Peter W.; Hermsmeyer, Kent.

In: European Journal of Pharmacology, Vol. 72, No. 1, 10.06.1981, p. 87-91.

Research output: Contribution to journalArticle

Trapani, Angelo ; Matsuki, Norio ; Abel, Peter W. ; Hermsmeyer, Kent. / Norepinephrine produces tension through electromechanical coupling in rabbit ear artery. In: European Journal of Pharmacology. 1981 ; Vol. 72, No. 1. pp. 87-91.
@article{86afd6da68fd464585d544394fbd33a5,
title = "Norepinephrine produces tension through electromechanical coupling in rabbit ear artery",
abstract = "Membrane potential (Em) and contractile responses to norepinephrine (NE) were measured to determine whether electromechanical coupling is important in the rabbit ear artery. NE contraction and depolarization of the vascular muscle cells were both dose dependent, with a positive correlation between depolarization and tension generated by the vessel. These studies suggest that NE regulates vascular muscle contraction through an Em signal in the rabbit ear artery.",
author = "Angelo Trapani and Norio Matsuki and Abel, {Peter W.} and Kent Hermsmeyer",
year = "1981",
month = "6",
day = "10",
doi = "10.1016/0014-2999(81)90301-0",
language = "English",
volume = "72",
pages = "87--91",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Norepinephrine produces tension through electromechanical coupling in rabbit ear artery

AU - Trapani, Angelo

AU - Matsuki, Norio

AU - Abel, Peter W.

AU - Hermsmeyer, Kent

PY - 1981/6/10

Y1 - 1981/6/10

N2 - Membrane potential (Em) and contractile responses to norepinephrine (NE) were measured to determine whether electromechanical coupling is important in the rabbit ear artery. NE contraction and depolarization of the vascular muscle cells were both dose dependent, with a positive correlation between depolarization and tension generated by the vessel. These studies suggest that NE regulates vascular muscle contraction through an Em signal in the rabbit ear artery.

AB - Membrane potential (Em) and contractile responses to norepinephrine (NE) were measured to determine whether electromechanical coupling is important in the rabbit ear artery. NE contraction and depolarization of the vascular muscle cells were both dose dependent, with a positive correlation between depolarization and tension generated by the vessel. These studies suggest that NE regulates vascular muscle contraction through an Em signal in the rabbit ear artery.

UR - http://www.scopus.com/inward/record.url?scp=0019449067&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019449067&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(81)90301-0

DO - 10.1016/0014-2999(81)90301-0

M3 - Article

C2 - 7262196

AN - SCOPUS:0019449067

VL - 72

SP - 87

EP - 91

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1

ER -