Norepinephrine produces tension through electromechanical coupling in rabbit ear artery

Angelo Trapani, Norio Matsuki, Peter W. Abel, Kent Hermsmeyer

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Membrane potential (Em) and contractile responses to norepinephrine (NE) were measured to determine whether electromechanical coupling is important in the rabbit ear artery. NE contraction and depolarization of the vascular muscle cells were both dose dependent, with a positive correlation between depolarization and tension generated by the vessel. These studies suggest that NE regulates vascular muscle contraction through an Em signal in the rabbit ear artery.

Original languageEnglish (US)
Pages (from-to)87-91
Number of pages5
JournalEuropean Journal of Pharmacology
Volume72
Issue number1
DOIs
StatePublished - Jun 10 1981
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology

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